Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
about
Exploring the active site of the Streptococcus pneumoniae topoisomerase IV-DNA cleavage complex with novel 7,8-bridged fluoroquinolonesThiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyraseSuppression of gyrase-mediated resistance by C7 aryl fluoroquinolones.Antibacterial small molecules targeting the conserved TOPRIM domain of DNA gyrase.Keep it together: restraints in crystallographic refinement of macromolecule-ligand complexes.Targeting bacterial topoisomerases: how to counter mechanisms of resistance.Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.Structure of a quinolone-stabilized cleavage complex of topoisomerase IV from Klebsiella pneumoniae and comparison with a related Streptococcus pneumoniae complex.The antibacterial agent, moxifloxacin inhibits virulence factors of Candida albicans through multitargeting.Novel Bacterial Topoisomerase Inhibitors Exploit Asp83 and the Intrinsic Flexibility of the DNA Gyrase Binding Site.DNA Topoisomerases as Targets for Antibacterial Agents.Topoisomerases as anticancer targets.Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences.A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.The Macromolecular Machines that Duplicate the Escherichia coli Chromosome as Targets for Drug Discovery.Trapping of the transport-segment DNA by the ATPase domains of a type II topoisomerase.
P2860
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P2860
Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年論文
@yue
2015年論文
@zh-hant
2015年論文
@zh-hk
2015年論文
@zh-mo
2015年論文
@zh-tw
2015年论文
@wuu
2015年论文
@zh
2015年论文
@zh-cn
name
Structural basis of DNA gyrase ...... ug etoposide and moxifloxacin.
@en
type
label
Structural basis of DNA gyrase ...... ug etoposide and moxifloxacin.
@en
prefLabel
Structural basis of DNA gyrase ...... ug etoposide and moxifloxacin.
@en
P2093
P2860
P356
P1476
Structural basis of DNA gyrase ...... rug etoposide and moxifloxacin
@en
P2093
Andrew J Theobald
Andrew P Fosberry
Anthony J Shillings
Carol Shen
Claus E Spitzfaden
Haifeng Cui
Jason Pizzollo
Jianzhong Huang
Karen Ingraham
Martin Hibbs
P2860
P2888
P356
10.1038/NCOMMS10048
P407
P577
2015-12-07T00:00:00Z