Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions. - Wikidata - wikimedia - TriplyDB

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions.

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions.

http://www.wikidata.org/entity/Q40240320

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Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180.The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts Glycosylphosphatidylinositol-anchored high-density lipoprotein-binding protein 1 plays a critical role in the lipolytic processing of chylomicrons Angiogenin interacts with the plasminogen activation system at the cell surface of breast cancer cells to regulate plasmin formation and cell migration The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180): membrane proteins engaged in matrix turnover during tissue remodeling Restoration of IFNγR subunit assembly, IFNγ signaling and parasite clearance in Leishmania donovani infected macrophages: role of membrane cholesterol uPAR-induced cell adhesion and migration: vitronectin provides the key Number and brightness image analysis reveals ATF-induced dimerization kinetics of uPAR in the cell membrane Mapping of the vitronectin-binding site on the urokinase receptor: involvement of a coherent receptor interface consisting of residues from both domain I and the flanking interdomain linker region.Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins.Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.Lipid raft-mediated regulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: a computational study Urokinase-type plasminogen activator receptor (uPAR) ligation induces a raft-localized integrin signaling switch that mediates the hypermotile phenotype of fibrotic fibroblasts Microglia and the urokinase plasminogen activator receptor/uPA system in innate brain inflammation.Golgi sorting regulates organization and activity of GPI proteins at apical membranes Localization of uPAR and MMP-9 in lipid rafts is critical for migration, invasion and angiogenesis in human breast cancer cells Relationships between EGFR signaling-competent and endocytosis-competent membrane microdomains The transmembrane region is responsible for targeting of adaptor protein LAX into "heavy rafts"Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures Coordinate regulation of fibronectin matrix assembly by the plasminogen activator system and vitronectin in human osteosarcoma cells.Native ligands change integrin sequestering but not oligomerization in raft-mimicking lipid mixtures.Characterization of the dimerization interface of membrane type 4 (MT4)-matrix metalloproteinase Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.A new class of orthosteric uPAR·uPA small-molecule antagonists are allosteric inhibitors of the uPAR·vitronectin interaction A transformation in the mechanism by which the urokinase receptor signals provides a selection advantage for estrogen receptor-expressing breast cancer cells in the absence of estrogen Dissecting mannose 6-phosphate-insulin-like growth factor 2 receptor complexes that control activation and uptake of plasminogen in cells.Monomer dimer dynamics and distribution of GPI-anchored uPAR are determined by cell surface protein assemblies Bilayer asymmetry influences integrin sequestering in raft-mimicking lipid mixtures.Sphingosine-1-phosphate and interleukin-1 independently regulate plasminogen activator inhibitor-1 and urokinase-type plasminogen activator receptor expression in glioblastoma cells: implications for invasiveness Mannose 6-phosphate/insulin-like growth factor 2 receptor limits cell invasion by controlling alphaVbeta3 integrin expression and proteolytic processing of urokinase-type plasminogen activator receptor.Fluorescence correlation spectroscopy and photon counting histogram on membrane proteins: functional dynamics of the glycosylphosphatidylinositol-anchored urokinase plasminogen activator receptor.Monocyte urokinase-type plasminogen activator up-regulation reduces thrombus size in a model of venous thrombosis.Role of the urokinase plasminogen activator receptor in mediating impaired efferocytosis of anti-SSA/Ro-bound apoptotic cardiocytes: Implications in the pathogenesis of congenital heart block.Primary focal and segmental glomerulosclerosis and soluble factor urokinase-type plasminogen activator receptor Lipid rafts: integrated platforms for vascular organization offering therapeutic opportunities.The urokinase receptor takes control of cell migration by recruiting integrins and FPR1 on the cell surface The cross-talk between the urokinase receptor and fMLP receptors regulates the activity of the CXCR4 chemokine receptor.Identification and role of the homodimerization interface of the glycosylphosphatidylinositol-anchored membrane type 6 matrix metalloproteinase (MMP25)Crowding effects of membrane proteins.

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P2860

Dimerization controls the lipid raft partitioning of uPAR/CD87 and regulates its biological functions.

http://www.wikidata.org/entity/Q40240320

description

2003 nî lūn-bûn

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2003年の論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年論文

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2003年论文

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2003年论文

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2003年论文

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name

Dimerization controls the lipi ...... ates its biological functions.

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type

label

Dimerization controls the lipi ...... ates its biological functions.

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prefLabel

Dimerization controls the lipi ...... ates its biological functions.

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The EMBO Journal

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Dimerization controls the lipi ...... ates its biological functions.

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Annapaola Andolfo

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Francesco Blasi

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Lucia Iuzzolino

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Maria Lisa Santovito

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Nicolai Sidenius

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Orla Cunningham

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P2860

Anthrax toxin triggers endocytosis of its receptor via a lipid raft-mediated clathrin-dependent process

Cell signaling by receptor tyrosine kinases

Cell surface polarization during yeast mating.

Lipid rafts and signal transduction

Metalloproteases cleave the urokinase-type plasminogen activator receptor in the D1-D2 linker region and expose epitopes not present in the intact soluble receptor

The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line

Plasminogen activation by receptor-bound urokinase. A kinetic study with both cell-associated and isolated receptor

Cellular receptor for urokinase plasminogen activator. Carboxyl-terminal processing and membrane anchoring by glycosyl-phosphatidylinositol

Lipid domain structure of the plasma membrane revealed by patching of membrane components

Segregation of leading-edge and uropod components into specific lipid rafts during T cell polarization

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22

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22

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275445

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