Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.
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Single amino acid substitutions in the chemotactic sequence of urokinase receptor modulate cell migration and invasionMapping the topographic epitope landscape on the urokinase plasminogen activator receptor (uPAR) by surface plasmon resonance and X-ray crystallographyRetro-inverso Urokinase Receptor Antagonists for the Treatment of Metastatic Sarcomas.Probing binding and cellular activity of pyrrolidinone and piperidinone small molecules targeting the urokinase receptor.Multimerization of glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) and familial chylomicronemia from a serine-to-cysteine substitution in GPIHBP1 Ly6 domainAdministration of recombinant soluble urokinase receptor per se is not sufficient to induce podocyte alterations and proteinuria in miceTargeting tumor cell invasion and dissemination in vivo by an aptamer that inhibits urokinase-type plasminogen activator through a novel multifunctional mechanism.Small-molecule inhibition of the uPAR·uPA interaction: synthesis, biochemical, cellular, in vivo pharmacokinetics and efficacy studies in breast cancer metastasis.Improved PET imaging of uPAR expression using new (64)Cu-labeled cross-bridged peptide ligands: comparative in vitro and in vivo studies.Epithelial and stromal cell urokinase plasminogen activator receptor expression differentially correlates with survival in rectal cancer stages B and C patients.Protein-binding RNA aptamers affect molecular interactions distantly from their binding sitesMimicry of the regulatory role of urokinase in lamellipodia formation by introduction of a non-native interdomain disulfide bond in its receptor.Cyclization of the urokinase receptor-derived ser-arg-ser-arg-tyr Peptide generates a potent inhibitor of trans-endothelial migration of monocytes.Peptide-Based Optical uPAR Imaging for Surgery: In Vivo Testing of ICG-Glu-Glu-AE105Inhibitory Monoclonal Antibodies against Mouse Proteases Raised in Gene-Deficient Mice Block Proteolytic Functions in vivo.A flexible multidomain structure drives the function of the urokinase-type plasminogen activator receptor (uPAR)The acidic domain of the endothelial membrane protein GPIHBP1 stabilizes lipoprotein lipase activity by preventing unfolding of its catalytic domain.The urokinase receptor homolog Haldisin is a novel differentiation marker of stratum granulosum in squamous epithelia.The urokinase receptor-derived cyclic peptide [SRSRY] suppresses neovascularization and intravasation of osteosarcoma and chondrosarcoma cells.Structure-driven design of radionuclide tracers for non-invasive imaging of uPAR and targeted radiotherapy. The tale of a synthetic peptide antagonist.Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells.Urokinase plasminogen activator gene deficiency inhibits fracture cartilage remodeling.GPIHBP1 autoantibodies in a patient with unexplained chylomicronemia.Targeting the cross-talk between Urokinase receptor and Formyl peptide receptor type 1 to prevent invasion and trans-endothelial migration of melanoma cells.
P2860
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P2860
Conformational regulation of urokinase receptor function: impact of receptor occupancy and epitope-mapped monoclonal antibodies on lamellipodia induction.
description
2011 nî lūn-bûn
@nan
2011 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
Conformational regulation of u ...... ies on lamellipodia induction.
@ast
Conformational regulation of u ...... ies on lamellipodia induction.
@en
type
label
Conformational regulation of u ...... ies on lamellipodia induction.
@ast
Conformational regulation of u ...... ies on lamellipodia induction.
@en
prefLabel
Conformational regulation of u ...... ies on lamellipodia induction.
@ast
Conformational regulation of u ...... ies on lamellipodia induction.
@en
P2093
P2860
P50
P356
P1476
Conformational regulation of u ...... dies on lamellipodia induction
@en
P2093
Benedikte Jacobsen
Henrik Gårdsvoll
Mette C Kriegbaum
P2860
P304
33544-33556
P356
10.1074/JBC.M111.220087
P407
P577
2011-07-28T00:00:00Z