Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
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TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and developmentMicrotubule plus-end tracking proteins in neuronal developmentTau-tubulin kinaseTau and tauopathiesThe structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitorX-ray structural analysis of tau-tubulin kinase 1 and its interactions with small molecular inhibitorsMutations in TTBK2, encoding a kinase implicated in tau phosphorylation, segregate with spinocerebellar ataxia type 11.The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration.Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases.Roles of tau protein in health and disease.Differential regulation of polarized synaptic vesicle trafficking and synapse stability in neural circuit rewiring in Caenorhabditis elegansActin interaction and regulation of cyclin-dependent kinase 5/p35 complex activityTau-tubulin kinase 1 expression, phosphorylation and co-localization with phospho-Ser422 tau in the Alzheimer's disease brain.Proteomic analysis of novel targets associated with TrkA-mediated tyrosine phosphorylation signaling pathways in SK-N-MC neuroblastoma cells.Expression, purification and crystallization of a human tau-tubulin kinase 2 that phosphorylates tau protein.HIV-1-infected and immune-activated macrophages induce astrocytic differentiation of human cortical neural progenitor cells via the STAT3 pathway.A novel, ultrasensitive assay for tau: potential for assessing traumatic brain injury in tissues and biofluids.Morphine produces immunosuppressive effects in nonhuman primates at the proteomic and cellular levelsThe microtubule-associated protein tau is phosphorylated by SykPhosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells.Novel therapeutic strategies for the treatment of protein-misfolding diseases.A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans.HIV-1-infected and/or immune-activated macrophage-secreted TNF-alpha affects human fetal cortical neural progenitor cell proliferation and differentiationGlobal analysis of phosphorylation of tau by the checkpoint kinases Chk1 and Chk2 in vitroChanges in microtubule-associated protein tau during peripheral nerve injury and regeneration.Mediators of tau phosphorylation in the pathogenesis of Alzheimer's disease.TTBK2: a tau protein kinase beyond tau phosphorylation.Identification of dynamic changes in proteins associated with the cellular cytoskeleton after exposure to okadaic acid.Protein Phosphorylation is a Key Mechanism in Alzheimer's Disease.Hepatitis B virus and Homo sapiens proteome-wide analysis: A profusion of viral peptide overlaps in neuron-specific human proteins.Transcription factors CEP-1/p53 and CEH-23 collaborate with AAK-2/AMPK to modulate longevity in Caenorhabditis elegans.Human TTBK1, TTBK2 and MARK1 kinase toxicity in Drosophila melanogaster is exacerbated by co-expression of human Tau.Accelerated neurodegeneration and neuroinflammation in transgenic mice expressing P301L tau mutant and tau-tubulin kinase 1.Synapse Innervation and Associative Memory Cell Are Recruited for Integrative Storage of Whisker and Odor Signals in the Barrel Cortex through miRNA-Mediated Processes.Pathological phosphorylation of tau and TDP-43 by TTBK1 and TTBK2 drives neurodegeneration.Barrel Cortical Neuron Integrates Triple Associated Signals for Their Memory Through Receiving Epigenetic-Mediated New Synapse Innervations.Associative memory cells and their working principle in the brain.Tau Phosphorylation is Impacted by Rare AKAP9 Mutations Associated with Alzheimer Disease in African Americans.Study of 300,486 individuals identifies 148 independent genetic loci influencing general cognitive function.
P2860
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P2860
Tau-tubulin kinase 1 (TTBK1), a neuron-specific tau kinase candidate, is involved in tau phosphorylation and aggregation.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Tau-tubulin kinase 1 (TTBK1), ...... osphorylation and aggregation.
@en
type
label
Tau-tubulin kinase 1 (TTBK1), ...... osphorylation and aggregation.
@en
prefLabel
Tau-tubulin kinase 1 (TTBK1), ...... osphorylation and aggregation.
@en
P2093
P2860
P921
P1476
Tau-tubulin kinase 1 (TTBK1), ...... hosphorylation and aggregation
@en
P2093
James L Buescher
Ronald L Cerny
Shinji Sato
P2860
P304
P356
10.1111/J.1471-4159.2006.04059.X
P407
P577
2006-09-01T00:00:00Z