Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
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P1343
Characterization and structure determination of the Cdt1 binding domain of human minichromosome maintenance (Mcm) 6TORC2, a coactivator of cAMP-response element-binding protein, promotes Epstein-Barr virus reactivation from latency through interaction with viral BZLF1 proteinPrevention of DNA re-replication in eukaryotic cellsSelective killing of cancer cells by suppression of geminin activityMechanisms to control rereplication and implications for cancer.Ring of Change: CDC48/p97 Drives Protein Dynamics at ChromatinRe-replication of a centromere induces chromosomal instability and aneuploidyQuaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensingHBO1 histone acetylase activity is essential for DNA replication licensing and inhibited by GemininHBO1 histone acetylase is a coactivator of the replication licensing factor Cdt1Cdt1-binding protein GRWD1 is a novel histone-binding protein that facilitates MCM loading through its influence on chromatin architectureCRL4Cdt2: master coordinator of cell cycle progression and genome stabilityHistone acetyltransferase Hbo1: catalytic activity, cellular abundance, and links to primary cancersAPC/C--the master controller of origin licensing?Pediatric renal solitary fibrous tumor: report of a rare case and review of the literature.Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses.Jnk2 effects on tumor development, genetic instability and replicative stress in an oncogene-driven mouse mammary tumor model.SCF-FBXO31 E3 ligase targets DNA replication factor Cdt1 for proteolysis in the G2 phase of cell cycle to prevent re-replication.Structural insights into the Cdt1-mediated MCM2-7 chromatin loading.DNA damage drives an activin a-dependent induction of cyclooxygenase-2 in premalignant cells and lesions.Cdt1 is differentially targeted for degradation by anticancer chemotherapeutic drugs.Cdc6 cooperates with c-Myc to promote genome instability and epithelial to mesenchymal transition EMT in zebrafish.Homologous recombination is a primary pathway to repair DNA double-strand breaks generated during DNA rereplicationBenzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.Life without geminin.Cdt1 revisited: complex and tight regulation during the cell cycle and consequences of deregulation in mammalian cells.A molecular analysis provides novel insights into androgen receptor signalling in breast cancer.Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements.Chromatin remodeler sucrose nonfermenting 2 homolog (SNF2H) is recruited onto DNA replication origins through interaction with Cdc10 protein-dependent transcript 1 (Cdt1) and promotes pre-replication complex formation.Enhanced phosphorylation of transcription factor sp1 in response to herpes simplex virus type 1 infection is dependent on the ataxia telangiectasia-mutated proteinThe ATR-mediated S phase checkpoint prevents rereplication in mammalian cells when licensing control is disrupted.Identification of novel human Cdt1-binding proteins by a proteomics approach: proteolytic regulation by APC/CCdh1SCF(Cyclin F)-dependent degradation of CDC6 suppresses DNA re-replication.Chromatin-associated degradation is defined by UBXN-3/FAF1 to safeguard DNA replication fork progression.Cdt1 and Cdc6 are destabilized by rereplication-induced DNA damage.Divergent S phase checkpoint activation arising from prereplicative complex deficiency controls cell survival.ATM regulates Cdt1 stability during the unperturbed S phase to prevent re-replication.GRWD1 negatively regulates p53 via the RPL11-MDM2 pathway and promotes tumorigenesis.The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery.A spontaneous Cdt1 mutation in 129 mouse strains reveals a regulatory domain restraining replication licensing.
P2860
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P2860
Deregulation of Cdt1 induces chromosomal damage without rereplication and leads to chromosomal instability.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Deregulation of Cdt1 induces c ...... ds to chromosomal instability.
@en
type
label
Deregulation of Cdt1 induces c ...... ds to chromosomal instability.
@en
prefLabel
Deregulation of Cdt1 induces c ...... ds to chromosomal instability.
@en
P2093
P50
P356
P1476
Deregulation of Cdt1 induces c ...... ads to chromosomal instability
@en
P2093
Mako Narisawa-Saito
Takashi Yugawa
Tohru Kiyono
P304
P356
10.1242/JCS.03031
P407
P4510
P577
2006-07-11T00:00:00Z