Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
about
Legal but lethal: functional protein aggregation at the verge of toxicityLiat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeatsReal-time detection of N-end rule-mediated ubiquitination via fluorescently labeled substrate probes.Generation of Artificial N-end Rule Substrate Proteins In Vivo and In Vitro.Co-expression of truncated and full-length tau induces severe neurotoxicityA neurostimulant para-chloroamphetamine inhibits the arginylation branch of the N-end rule pathway.Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis.Annotating N termini for the human proteome project: N termini and Nα-acetylation status differentiate stable cleaved protein species from degradation remnants in the human erythrocyte proteomeUbiquitin reference technique and its use in ubiquitin-lacking prokaryotes.Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone.Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications.Degradation of the Separase-cleaved Rec8, a Meiotic Cohesin Subunit, by the N-end Rule Pathway.Posttranslational arginylation enzyme Ate1 affects DNA mutagenesis by regulating stress responseCalpain-generated natural protein fragments as short-lived substrates of the N-end rule pathway.The N-terminal methionine of cellular proteins as a degradation signalProtein Quality Control by Molecular Chaperones in Neurodegeneration.Cellular maintenance of nuclear protein homeostasisFormyl-methionine as a degradation signal at the N-termini of bacterial proteins.Post-translational protein arginylation in the normal nervous system and in neurodegeneration.Physiological functions and clinical implications of the N-end rule pathway.Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway.p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis.DPP9 is a novel component of the N-end rule pathway targeting the tyrosine kinase Syk.Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegenerationThe ClpS-like N-domain is essential for the functioning of Ubr11, an N-recognin in Schizosaccharomyces pombe.The N-end rule pathway regulates pathogen responses in plants.Analyzing N-terminal Arginylation through the Use of Peptide Arrays and Degradation Assays.The arginylation branch of the N-end rule pathway positively regulates cellular autophagic flux and clearance of proteotoxic proteins.An N-end rule pathway that recognizes proline and destroys gluconeogenic enzymes.Starting with a degron: N-terminal formyl-methionine of nascent bacterial proteins contributes to their proteolytic control.Control of Hsp90 chaperone and its clients by N-terminal acetylation and the N-end rule pathway.A picorna-like virus suppresses the N-end rule pathway to inhibit apoptosis.A reference-based protein degradation assay without global translation inhibitors.Coupled Caspase and N-End Rule Ligase Activities Allow Recognition and Degradation of Pluripotency Factor LIN-28 during Non-Apoptotic Development.N-terminal arginylation generates a bimodal degron that modulates autophagic proteolysis.The N Termini of TAR DNA-Binding Protein 43 (TDP43) C-Terminal Fragments Influence Degradation, Aggregation Propensity, and Morphology
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P2860
Neurodegeneration-associated protein fragments as short-lived substrates of the N-end rule pathway.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Neurodegeneration-associated p ...... tes of the N-end rule pathway.
@en
type
label
Neurodegeneration-associated p ...... tes of the N-end rule pathway.
@en
prefLabel
Neurodegeneration-associated p ...... tes of the N-end rule pathway.
@en
P2093
P2860
P1433
P1476
Neurodegeneration-associated p ...... tes of the N-end rule pathway.
@en
P2093
Alexander Varshavsky
Christopher S Brower
Konstantin I Piatkov
P2860
P304
P356
10.1016/J.MOLCEL.2013.02.009
P577
2013-03-14T00:00:00Z