The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.
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Identification of the SPLUNC1 ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airway epithelial culturesEpithelial Na(+) channel regulation by cytoplasmic and extracellular factorsENaC regulation by proteases and shear stressBlood pressure and amiloride-sensitive sodium channels in vascular and renal cellsRegulation and dysregulation of epithelial Na+ channelsA long isoform of the epithelial sodium channel alpha subunit forms a highly active channelEpithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseasesNedd4-2 induces endocytosis and degradation of proteolytically cleaved epithelial Na+ channelsExpression and purification of the alpha subunit of the epithelial sodium channel, ENaC.Plasmin activates epithelial Na+ channels by cleaving the gamma subunit.Function and dynamics of PKD2 in Chlamydomonas reinhardtii flagella.Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases.A segment of gamma ENaC mediates elastase activation of Na+ transportCysteine palmitoylation of the γ subunit has a dominant role in modulating activity of the epithelial sodium channelNew role for plasmin in sodium homeostasis.Regulation of sodium transport by ENaC in the kidneyInterleukin-6 stimulates epithelial sodium channels in mouse cortical collecting duct cellsRole of epithelial sodium channels and their regulators in hypertension.Cys palmitoylation of the beta subunit modulates gating of the epithelial sodium channelDefining an inhibitory domain in the gamma subunit of the epithelial sodium channelProteolytic activation of the epithelial sodium channel and therapeutic application of a serine protease inhibitor for the treatment of salt-sensitive hypertension.Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains.Prostasin interacts with the epithelial Na+ channel and facilitates cleavage of the γ-subunit by a second proteaseNa+ inhibits the epithelial Na+ channel by binding to a site in an extracellular acidic cleftSecond transmembrane domain modulates epithelial sodium channel gating in response to shear stressExternal Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains.ENaC structure and function in the wake of a resolved structure of a family member.Sodium retention and volume expansion in nephrotic syndrome: implications for hypertension.TMPRSS4-dependent activation of the epithelial sodium channel requires cleavage of the γ-subunit distal to the furin cleavage sitePendrin gene ablation alters ENaC subcellular distribution and open probabilityENaCs and ASICs as therapeutic targets.Extracellular finger domain modulates the response of the epithelial sodium channel to shear stressInhibitory tract traps the epithelial Na+ channel in a low activity conformation.Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Identification of SPLUNC1's ENaC-inhibitory domain yields novel strategies to treat sodium hyperabsorption in cystic fibrosis airways.Regulation of transport in the connecting tubule and cortical collecting ductFeedback inhibition of ENaC during acute sodium loading in vivo.Prostasin expression is regulated by airway surface liquid volume and is increased in cystic fibrosis.Role of Epithelium Sodium Channel in Bone Formation.Regulation of the epithelial Na+ channel by peptidases.
P2860
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P2860
The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
The epithelial Na+ channel is ...... ocessing of its alpha subunit.
@en
type
label
The epithelial Na+ channel is ...... ocessing of its alpha subunit.
@en
prefLabel
The epithelial Na+ channel is ...... ocessing of its alpha subunit.
@en
P2093
P2860
P356
P1476
The epithelial Na+ channel is ...... rocessing of its alpha subunit
@en
P2093
James B Bruns
Joseph M Pilewski
Marcelo D Carattino
Rebecca P Hughey
Thomas R Kleyman
P2860
P304
18901-18907
P356
10.1074/JBC.M604109200
P407
P50
P577
2006-05-11T00:00:00Z