about
Blood pressure and amiloride-sensitive sodium channels in vascular and renal cellsEpithelial sodium channel pore region. structure and role in gating.External Cu2+ inhibits human epithelial Na+ channels by binding at a subunit interface of extracellular domains.Functional Roles of Clusters of Hydrophobic and Polar Residues in the Epithelial Na+ Channel Knuckle Domain.Probing the structural basis of Zn2+ regulation of the epithelial Na+ channel.Deletion of α-subunit exon 11 of the epithelial Na+ channel reveals a regulatory moduleEpithelial Sodium Channel ENaC is a Modifier of the Long Term Non-progressive Phenotype Associated with F508del CFTR Mutations.Epithelial Na+ channels are fully activated by furin- and prostasin-dependent release of an inhibitory peptide from the gamma-subunit.The epithelial Na+ channel is inhibited by a peptide derived from proteolytic processing of its alpha subunit.Human epithelial Na+ channel missense variants identified in the GenSalt study alter channel activity.Novel determinants of epithelial sodium channel gating within extracellular thumb domains.Mutations in the pore region modify epithelial sodium channel gating by shear stress.External nickel inhibits epithelial sodium channel by binding to histidine residues within the extracellular domains of alpha and gamma subunits and reducing channel open probability.Second transmembrane domains of ENaC subunits contribute to ion permeation and selectivity.Asymmetric organization of the pore region of the epithelial sodium channel.Multiple epithelial Na+ channel domains participate in subunit assembly.Epithelial Na+ channels are activated by laminar shear stress.Extracellular histidine residues crucial for Na+ self-inhibition of epithelial Na+ channels.Side chain orientation of residues lining the selectivity filter of epithelial Na+ channels.On the interaction between amiloride and its putative alpha-subunit epithelial Na+ channel binding site.Extracellular Zn2+ activates epithelial Na+ channels by eliminating Na+ self-inhibition.Functional polymorphism in the carboxyl terminus of the alpha-subunit of the human epithelial sodium channel.Functional role of extracellular loop cysteine residues of the epithelial Na+ channel in Na+ self-inhibition.Biophysical approach to determine the subunit stoichiometry of the epithelial sodium channel using the Xenopus laevis oocyte expression system.Furin cleavage activates the epithelial Na+ channel by relieving Na+ self-inhibition.Analyses of epithelial Na+ channel variants reveal that an extracellular β-ball domain critically regulates ENaC gatingThumb domains of the three epithelial Na+ channel subunits have distinct functions
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description
researcher
@en
wetenschapper
@nl
հետազոտող
@hy
name
Shaohu Sheng
@ast
Shaohu Sheng
@en
Shaohu Sheng
@es
Shaohu Sheng
@nl
Shaohu Sheng
@sl
type
label
Shaohu Sheng
@ast
Shaohu Sheng
@en
Shaohu Sheng
@es
Shaohu Sheng
@nl
Shaohu Sheng
@sl
prefLabel
Shaohu Sheng
@ast
Shaohu Sheng
@en
Shaohu Sheng
@es
Shaohu Sheng
@nl
Shaohu Sheng
@sl
P1053
G-7052-2016
P106
P31
P3829
P496
0000-0002-7198-1702