Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase. - Wikidata - wikimedia - TriplyDB

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

http://www.wikidata.org/entity/Q40285122

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14-3-3ζ turns TGF-β's function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2 Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway The role of the ubiquitin proteasome system in cerebellar development and medulloblastoma Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy Hedgehog signaling inhibitors as anti-cancer agents in osteosarcoma Decoding the phosphorylation code in Hedgehog signal transduction GATA6 is a crucial regulator of Shh in the limb bud Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved The primary cilium as a complex signaling center beta-TrCP inhibition reduces prostate cancer cell growth via upregulation of the aryl hydrocarbon receptor.Inducible priming phosphorylation promotes ligand-independent degradation of the IFNAR1 chain of type I interferon receptor Thymosin beta-4 regulates activation of hepatic stellate cells via hedgehog signaling.Mechanism and evolution of cytosolic Hedgehog signal transduction GLI1 confers profound phenotypic changes upon LNCaP prostate cancer cells that include the acquisition of a hormone independent state Deletion analysis of BMI1 oncoprotein identifies its negative regulatory domain SUMOylation by Pias1 regulates the activity of the Hedgehog dependent Gli transcription factors Role of β-TrCP ubiquitin ligase receptor in UVB mediated responses in skin.Hedgehog signaling in prostate epithelial-mesenchymal growth regulation.ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma.Basal cell carcinomas: attack of the hedgehog.Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists.Hedgehog secretion and signal transduction in vertebrates.Regulation of Hedgehog signaling by ubiquitination.BRG1 interacts with GLI2 and binds Mef2c gene in a hedgehog signalling dependent manner during in vitro cardiomyogenesis Combined application of arsenic trioxide and lithium chloride augments viability reduction and apoptosis induction in human rhabdomyosarcoma cell lines.Hedgehog signaling in development and homeostasis of the gastrointestinal tract.Controlling hair follicle signaling pathways through polyubiquitination.GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.Thiazolidinediones mimic glucose starvation in facilitating Sp1 degradation through the up-regulation of beta-transducin repeat-containing protein.Hedgehog-Gli signaling pathway inhibitors as anticancer agents.The Sonic Hedgehog pathway stimulates prostate tumor growth by paracrine signaling and recapitulates embryonic gene expression in tumor myofibroblasts Protein kinase inhibitor SU6668 attenuates positive regulation of Gli proteins in cancer and multipotent progenitor cells.A central region of Gli2 regulates its localization to the primary cilium and transcriptional activity Hedgehog and TGFβ signaling converge on Gli2 to control bony invasion and bone destruction in oral squamous cell carcinoma Crosstalk between TGF-β and hedgehog signaling in cancer.Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle control.How is digit identity determined during limb development?New prospects for drug development: the hedgehog pathway revealed. Focus on hematologic malignancies.Oncoprotein stabilization in brain tumors.Selective modulation of Hedgehog/GLI target gene expression by epidermal growth factor signaling in human keratinocytes.

P2860

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P2860

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

http://www.wikidata.org/entity/Q40285122

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

@zh-hk

2006年論文

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2006年論文

@zh-tw

2006年论文

@wuu

2006年论文

@zh

2006年论文

@zh-cn

name

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

@en

type

label

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

@en

prefLabel

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase.

@en

P1433

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P1476

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P921

Q40285122-77D17292-0EB1-47DB-976A-902679C8530B

P356

P1433

Journal of Biological Chemistry

P1476

Gli2 is targeted for ubiquitination and degradation by beta-TrCP ubiquitin ligase

@en

P2093

Andrzej Dlugosz

http://www.w3.org/2001/XMLSchema#string

Hasan Mukhtar

http://www.w3.org/2001/XMLSchema#string

Irina Elcheva

http://www.w3.org/2001/XMLSchema#string

Neehar Bhatia

http://www.w3.org/2001/XMLSchema#string

Saravanan Thiyagarajan

http://www.w3.org/2001/XMLSchema#string

Vladimir S Spiegelman

http://www.w3.org/2001/XMLSchema#string

P2860

Sonic Hedgehog-induced activation of the Gli1 promoter is mediated by GLI3

GLI2 is expressed in normal human epidermis and BCC and induces GLI1 expression by binding to its promoter

SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor

Human GLI2 and GLI1 are part of a positive feedback mechanism in Basal Cell Carcinoma

Sonic hedgehog activates mesenchymal Gli1 expression during prostate ductal bud formation

Activation of the hedgehog pathway in advanced prostate cancer

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

The zinc-finger transcription factor GLI2 antagonizes contact inhibition and differentiation of human epidermal cells

Regulation of the cell cycle by SCF-type ubiquitin ligases

The Hedgehog response network: sensors, switches, and routers

P304

19320-19326

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P31

scholarly article

P356

10.1074/JBC.M513203200

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P407

P433

28

http://www.w3.org/2001/XMLSchema#string

P478

281

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P50

Mohammad Saleem

P577

2006-05-01T00:00:00Z

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P5875

7130674

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P698

16651270

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P921

protein ubiquitination