Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. - Wikidata - wikimedia - TriplyDB

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

http://www.wikidata.org/entity/Q40314036

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Animal Models for Fibrotic Liver Diseases: What We Have, What We Need, and What Is under Development Evolving therapies for liver fibrosis.Broad-spectrum matrix metalloproteinase inhibition curbs inflammation and liver injury but aggravates experimental liver fibrosis in mice Ethanol exposure depletes hepatic pigment epithelium-derived factor, a novel lipid regulator.Macrophage-mediated phagocytosis of apoptotic cholangiocytes contributes to reversal of experimental biliary fibrosis.The antifibrotic drug halofuginone inhibits proliferation and collagen production by human leiomyoma and myometrial smooth muscle cells Repopulation of the fibrotic/cirrhotic rat liver by transplanted hepatic stem/progenitor cells and mature hepatocytes.Hepatitis C virus regulates transforming growth factor beta1 production through the generation of reactive oxygen species in a nuclear factor kappaB-dependent manner.Microarray profiling reveals the integrated stress response is activated by halofuginone in mammary epithelial cells.Human T cell microparticles circulate in blood of hepatitis patients and induce fibrolytic activation of hepatic stellate cells.HIV and HCV cooperatively promote hepatic fibrogenesis via induction of reactive oxygen species and NFkappaB Class II HDAC inhibition hampers hepatic stellate cell activation by induction of microRNA-29 High microvessel density determines a poor outcome in patients with diffuse large B-cell lymphoma treated with rituximab plus chemotherapy.Enamel matrix derivative protein enhances production of matrixmetalloproteinase-2 by osteoblasts.Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts.Tissue transglutaminase does not affect fibrotic matrix stability or regression of liver fibrosis in mice CFTR dysfunction predisposes to fibrotic liver disease in a murine model Animal models of portal hypertension IL-1β-specific recruitment of GCN5 histone acetyltransferase induces the release of PAF1 from chromatin for the de-repression of inflammatory response genes.Halofuginone suppresses growth of human uterine leiomyoma cells in a mouse xenograft model NF-kappa B: a new player in angiostatic therapy Microvascular targets for anti-fibrotic therapeutics Pharmacological inhibition of integrin alphavbeta3 aggravates experimental liver fibrosis and suppresses hepatic angiogenesis.Vascular endothelial growth factor promotes fibrosis resolution and repair in mice.Therapeutic targets in liver fibrosis.Halofuginone for fibrosis, regeneration and cancer in the gastrointestinal tract.Halofuginone - the multifaceted molecule.Inhibitory effect of peroxiredoxin II (Prx II) on Ras-ERK-NFkappaB pathway in mouse embryonic fibroblast (MEF) senescence.Attenuation of hepatic fibrosis by an imidazolium salt in thioacetamide-induced mouse model.Inhibition of integrin alphavbeta6 on cholangiocytes blocks transforming growth factor-beta activation and retards biliary fibrosis progression.Failure of fibrotic liver regeneration in mice is linked to a severe fibrogenic response driven by hepatic progenitor cell activation.Hydroxyproline-containing collagen analogs trigger the release and activation of collagen-sequestered proMMP-2 by competition with prodomain-derived peptide P33-42.Targeting liver myofibroblasts: a novel approach in anti-fibrogenic therapy.Halofuginone ameliorates inflammation in severe acute hepatitis B virus (HBV)-infected SD rats through AMPK activation.Role of the receptor for advanced glycation end products in hepatic fibrosis.Changes in microRNAs associated with hepatic stellate cell activation status identify signaling pathways.An intravital microscopic study of the hepatic microcirculation in cirrhotic mice models: relationship between fibrosis and angiogenesis.Halofuginone upregulates the expression of heparanase in thioacetamide-induced liver fibrosis in rats.Addressing liver fibrosis with liposomes targeted to hepatic stellate cells.Human bone marrow mesenchymal stem cells suppress the proliferation of hepatic stellate cells by inhibiting the ubiquitination of p27.

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P2860

Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB.

http://www.wikidata.org/entity/Q40314036

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年論文

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2006年论文

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2006年论文

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2006年论文

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name

Halofuginone induces matrix me ...... ctivation of p38 and NFkappaB.

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Halofuginone induces matrix me ...... ctivation of p38 and NFkappaB.

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Halofuginone induces matrix me ...... ctivation of p38 and NFkappaB.

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P1476

Halofuginone induces matrix me ...... ctivation of p38 and NFkappaB.

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P2093

Anja Schulze-Krebs

http://www.w3.org/2001/XMLSchema#string

Detlef Schuppan

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Edith Niedobitek

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Eleonora Patsenker

http://www.w3.org/2001/XMLSchema#string

Michael Bauer

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Yury Popov

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P2860

Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase

Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct.

Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats.

Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization.

Extracellular matrix degradation and the role of hepatic stellate cells.

Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma.

Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis.

Reciprocal modulation of matrix metalloproteinase-13 and type I collagen genes in rat hepatic stellate cells.

Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation.

Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins.

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15090-15098

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10.1074/JBC.M600030200

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281

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7288410

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16489207

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