Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.
about
Peptide-Like Molecules (PLMs): A Journey from Peptide Bond Isosteres to Gramicidin S Mimetics and Mitochondrial Targeting Agents.Constraining cyclic peptides to mimic protein structure motifs.Trisubstituted (E)-alkene dipeptide isosteres as beta-turn promoters in the gramicidin S cyclodecapeptide scaffold.Sequence inversion and phenylalanine surrogates at the beta-turn enhance the antibiotic activity of gramicidin S.Therapeutic index of gramicidin S is strongly modulated by D-phenylalanine analogues at the beta-turn.A compendium of cyclic sugar amino acids and their carbocyclic and heterocyclic nitrogen analogues.Salt-bridging effects on short amphiphilic helical structure and introducing sequence-based short beta-turn motifs.Tetrahydrofuran amino acid-containing gramicidin S analogues with improved biological profiles.Enhanced antimicrobial activity of a peptide derived from human lysozyme by arylation of its tryptophan residues.Exploring the conformational and biological versatility of β-turn-modified gramicidin S by using sugar amino acid homologues that vary in ring size.Towards the synthesis of sugar amino acid containing antimicrobial noncytotoxic CAP conjugates with gold nanoparticles and a mechanistic study of cell disruption.Thiazole-Based γ-Building Blocks as Reverse-Turn Mimetic to Design a Gramicidin S Analogue: Conformational and Biological Evaluation
P2860
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P2860
Beta-turn modified gramicidin S analogues containing arylated sugar amino acids display antimicrobial and hemolytic activity comparable to the natural product.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Beta-turn modified gramicidin ...... arable to the natural product.
@en
type
label
Beta-turn modified gramicidin ...... arable to the natural product.
@en
prefLabel
Beta-turn modified gramicidin ...... arable to the natural product.
@en
P2093
P50
P356
P1476
Beta-turn modified gramicidin ...... arable to the natural product.
@en
P2093
Albert J de Neeling
Annelies E M Buizert
Daan Noort
Emile Spalburg
Gijsbert A van der Marel
Gijsbert M Grotenbreg
Mark Overhand
Peter A V van Hooft
P304
P356
10.1021/JA0588510
P407
P577
2006-06-01T00:00:00Z