about
Role of Varp, a Rab21 exchange factor and TI-VAMP/VAMP7 partner, in neurite growthA role for the small GTPase Rab21 in the early endocytic pathwayCNIH4 interacts with newly synthesized GPCR and controls their export from the endoplasmic reticulumGamma-BAR, a novel AP-1-interacting protein involved in post-Golgi trafficking.High-content screening microscopy identifies novel proteins with a putative role in secretory membrane trafficLocalizing the proteomeMalectin: A Novel Carbohydrate-binding Protein of the Endoplasmic Reticulum and a Candidate Player in the Early Steps of Protein N-GlycosylationRab18 and Rab43 have key roles in ER-Golgi traffickingChemical chaperones improve protein secretion and rescue mutant factor VIII in mice with hemophilia AAnti-prion drug mPPIg5 inhibits PrP(C) conversion to PrP(Sc)The Spir actin organizers are involved in vesicle transport processesBiogenesis of tubular ER-to-Golgi transport intermediates.High-content microscopy identifies new neurite outgrowth regulators.A real-time impedance based method to assess Rhodococcus equi virulence.A microscope-based screening platform for large-scale functional protein analysis in intact cells.The systematic functional characterisation of Xq28 genes prioritises candidate disease genes.Analysis of intraviral protein-protein interactions of the SARS coronavirus ORFeome.Screening the secretion machinery: High throughput imaging approaches to elucidate the secretory pathway.Endoplasmic reticulum stress-activated transcription factor ATF6α requires the disulfide isomerase PDIA5 to modulate chemoresistanceA novel laser nanosurgery approach supports de novo Golgi biogenesis in mammalian cells.Dual channel rank-based intensity weighting for quantitative co-localization of microscopy images.A role for kinesin-2 in COPI-dependent recycling between the ER and the Golgi complex.Quantitative proteomics and dynamic imaging of the nucleolus reveal distinct responses to UV and ionizing radiation.The subcellular localization of the mammalian proteome comes a fraction closerMaturation of the mammalian secretome.Implementation of the Rank-Weighted Co-localization (RWC) algorithm in multiple image analysis platforms for quantitative analysis of microscopy images.Impact of live cell imaging on coated vesicle research.Human diseases associated with form and function of the Golgi complex.The trials and tubule-ations of Rab6 involvement in Golgi-to-ER retrograde transport.Trajectory-based co-localization measures for nanoparticle-cell interaction studies.Rho GTPases operating at the Golgi complex: Implications for membrane traffic and cancer biology.RNAi-mediated inhibition of apoptosis fails to prevent cationic nanoparticle-induced cell death in cultured cells.Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles.Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.Quantifying size-dependent interactions between fluorescently labeled polystyrene nanoparticles and mammalian cells.Cationic nanoparticles induce caspase 3-, 7- and 9-mediated cytotoxicity in a human astrocytoma cell line.Automated recognition system to classify subcellular protein localizations in images of different cell lines acquired by different imaging systems.Interferon-induced, antiviral human MxA protein localizes to a distinct subcompartment of the smooth endoplasmic reticulum.Intracellular traffic and fate of protein transduction domains HIV-1 TAT peptide and octaarginine. Implications for their utilization as drug delivery vectors.Spatiotemporal dynamics of the COPI vesicle machinery.
P50
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P50
description
hulumtues
@sq
onderzoeker
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researcher
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ricercatore
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հետազոտող
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name
Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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type
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jez Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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Jeremy C. Simpson
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P214
P106
P1153
7404323490
P21
P214
P31
P496
0000-0002-7956-7805
P734
P7859
lccn-n00024574