Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
about
Modulation of Autophagy by Sorafenib: Effects on Treatment ResponseEndoplasmic reticulum stress activates the hepatic activator protein 1 complex via mitogen activated protein kinase-dependent signaling pathwaysBufalin Reverses Resistance to Sorafenib by Inhibiting Akt Activation in Hepatocellular Carcinoma: The Role of Endoplasmic Reticulum StressIntegrative quantitative proteomics unveils proteostasis imbalance in human hepatocellular carcinoma developed on nonfibrotic livers.A Mighty "Protein Extractor" of the Cell: Structure and Function of the p97/CDC48 ATPase.Pekinenin E Inhibits the Growth of Hepatocellular Carcinoma by Promoting Endoplasmic Reticulum Stress Mediated Cell Death.Combined inhibition of p97 and the proteasome causes lethal disruption of the secretory apparatus in multiple myeloma cells.Proteotoxic crisis, the ubiquitin-proteasome system, and cancer therapy.Inhibitors of the AAA+ chaperone p97Golgi fragmentation in amyotrophic lateral sclerosis, an overview of possible triggers and consequences.Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97.LincRNA-p21 activates endoplasmic reticulum stress and inhibits hepatocellular carcinomaChemical Modulation of Endocytic Sorting Augments Adeno-associated Viral Transduction.Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein ResponseNUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance.Cdc48: a swiss army knife of cell biology.The unfolded protein response in fatty liver disease.Untangling knots between autophagic targets and candidate drugs, in cancer therapy.Sorafenib impedes Rift Valley fever virus egress by inhibiting Valosin-containing protein function in the cellular secretory pathway.Cytotoxic mechanisms of panduratin A on A375 melanoma cells: A quantitative and temporal proteomics analysis.Comparative proteomics of exosomes secreted by tumoral Jurkat T cells and normal human T cell blasts unravels a potential tumorigenic role for valosin-containing protein.miR-339-5p inhibits cell migration and invasion in vitro and may be associated with the tumor-node-metastasis staging and lymph node metastasis of non-small cell lung cancerCell survival and protein secretion associated with Golgi integrity in response to Golgi stress-inducing agents.Protein biosynthesis, a target of sorafenib, interferes with the unfolded protein response (UPR) and ferroptosis in hepatocellular carcinoma cells.Proteostasis trumps YAP in colon cancer.High expression of valosin-containing protein predicts poor prognosis in patients with breast carcinoma.
P2860
Q26745320-F9B5CC76-907E-4DA7-B510-5D290ABCFAFAQ28391490-F4AD0A90-0195-4788-9CB8-99CB2AF0648BQ28548246-0A23A31D-0552-4E45-9AB0-69B59F0C89A0Q30397531-E4F82D9C-4B7D-413F-8BB5-FD5C8C40FEE3Q33790385-CA51E864-BA89-432E-8477-D36FF0A5E42DQ33849350-9A73092C-2ABA-413B-A2B0-D7E8E9C31F48Q34999190-5391B99B-C700-4660-AA1F-B0910CBCF24EQ35408665-F571D7A8-23FA-4F4C-AC61-0C1C3EB0C583Q36078289-8A3B245D-3120-464C-A977-95870649639DQ36211097-40C41EBC-C40C-47EE-8DA6-8A376C133E5AQ36367307-94EC83A1-6DA1-4DB1-AAB0-62C319B4BC0FQ36414001-85F030B2-97F2-4F11-8BF6-A0F3BDA42753Q36442455-D24B73E2-B1F5-489A-91BF-EF7EB2244F70Q37297058-385A48CA-1FE6-4B43-A9CC-01401A10CA68Q37482829-CB9A7354-130E-45D6-AA40-698AA21755DCQ38156177-9C17DB7E-40E4-44C2-A9E0-CAB6B8146B86Q38162132-98A2E619-FA8B-4C4D-9164-465BA008C6BAQ38343562-B362D30A-EB19-4CA8-9C26-1DC80FA94A60Q38631743-EEAE3D74-BD01-4812-9539-0DA37AF38A29Q38919337-36274A56-58F4-4B56-A212-F24BE6E3D38CQ41260269-3AC81F83-AA77-449C-BB97-E0E228C928F9Q41889833-1647ED2F-0FAE-4D2F-BFF8-98BF14D23DCBQ48170630-7FBD65E4-C49F-4F1E-BA8A-E90D46C332B0Q50321414-1C9FBC02-7C49-4A27-BD2B-2210D3271722Q50927285-9D9A92D3-2C62-44D5-A97C-4F2DEDEA073AQ52931471-95C668A4-4B16-40B7-B42A-75C2DD2C9F1F
P2860
Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@en
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@nl
type
label
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@en
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@nl
prefLabel
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@en
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@nl
P2093
P50
P1476
Sorafenib-mediated targeting o ...... atocellular cancer cell death.
@en
P2093
Arisa Higa
Charles Balabaud
Claire Castain
Daniela Arma
Eric Chevet
Esther Marza
Jean-Frédéric Blanc
Said Taouji
P304
P356
10.1158/1535-7163.MCT-12-0516
P577
2012-10-05T00:00:00Z