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Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

http://www.wikidata.org/entity/Q40330820

about

A single-amino-acid mutation in hepatitis C virus NS5A disrupting FKBP8 interaction impairs viral replication Inhibition of cyclophilins alters lipid trafficking and blocks hepatitis C virus secretion Biochemical mechanism of hepatitis C virus inhibition by the broad-spectrum antiviral arbidol The yin and yang of hepatitis C: synthesis and decay of hepatitis C virus RNA Impact of lipids and lipoproteins on hepatitis C virus infection and virus neutralization A metabolic network approach for the identification and prioritization of antimicrobial drug targets Targeted induction of interferon-λ in humanized chimeric mouse liver abrogates hepatotropic virus infection Critical Role of Virion-Associated Cholesterol and Sphingolipid in Hepatitis C Virus Infection Inhibition of Sphingosine Kinase by Bovine Viral Diarrhea Virus NS3 Is Crucial for Efficient Viral Replication and Cytopathogenesis Signal transduction pathways in liver and the influence of hepatitis C virus infection on their activities Proanthocyanidin from Blueberry Leaves Suppresses Expression of Subgenomic Hepatitis C Virus RNA Temporal Proteome and Lipidome Profiles Reveal Hepatitis C Virus-Associated Reprogramming of Hepatocellular Metabolism and Bioenergetics Role of sulfatide in normal and pathological cells and tissues Antiviral lectins from red and blue-green algae show potent in vitro and in vivo activity against hepatitis C virus Stearoyl-CoA desaturase inhibition blocks formation of hepatitis C virus-induced specialized membranes Human subtilase SKI-1/S1P is a master regulator of the HCV Lifecycle and a potential host cell target for developing indirect-acting antiviral agents HIV and mature dendritic cells: Trojan exosomes riding the Trojan horse?Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus.Regulation of the hepatitis C virus RNA replicase by endogenous lipid peroxidation.Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner.Self-enhancement of hepatitis C virus replication by promotion of specific sphingolipid biosynthesis.Capture and transfer of HIV-1 particles by mature dendritic cells converges with the exosome-dissemination pathway HCV 3a core protein increases lipid droplet cholesteryl ester content via a mechanism dependent on sphingolipid biosynthesis.Hepatitis C virus life cycle and lipid metabolism Viral glycosphingolipids induce lytic infection and cell death in marine phytoplankton.Role of lipid rafts in liver health and disease Admixture analysis of spontaneous hepatitis C virus clearance in individuals of African descent.Targeting cellular squalene synthase, an enzyme essential for cholesterol biosynthesis, is a potential antiviral strategy against hepatitis C virus.Plasma sphingolipids as potential indicators of hepatic necroinflammation in patients with chronic hepatitis C and normal alanine aminotransferase level.Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection.Lipid metabolite profiling identifies desmosterol metabolism as a new antiviral target for hepatitis C virus.CD59 incorporation protects hepatitis C virus against complement-mediated destruction.Lipids and RNA virus replication Phosphoinositides in the hepatitis C virus life cycle.Host sphingomyelin increases West Nile virus infection in vivo Viral serine palmitoyltransferase induces metabolic switch in sphingolipid biosynthesis and is required for infection of a marine alga Up-regulation of Plasma Hexosylceramide (d18: 1/18: 1) Contributes to Genotype 2 Virus Replication in Chronic Hepatitis C: A 20-Year Cohort Study Hepatitis C virus, cholesterol and lipoproteins--impact for the viral life cycle and pathogenesis of liver disease.Hepatitis C virus-host interactions: Etiopathogenesis and therapeutic strategies.Oxysterol-binding protein is a phosphatidylinositol 4-kinase effector required for HCV replication membrane integrity and cholesterol trafficking.

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P2860

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

http://www.wikidata.org/entity/Q40330820

description

2005 nî lūn-bûn

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2005年の論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年論文

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2005年论文

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2005年论文

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2005年论文

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name

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

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Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

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Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

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P1433

Nature Chemical Biology

P1476

Host sphingolipid biosynthesis as a target for hepatitis C virus therapy.

@en

P2093

Asao Katsume

http://www.w3.org/2001/XMLSchema#string

Atsunori Ohta

http://www.w3.org/2001/XMLSchema#string

Hideyuki Kato

http://www.w3.org/2001/XMLSchema#string

Hiroshi Sakamoto

http://www.w3.org/2001/XMLSchema#string

Koichi Okamoto

http://www.w3.org/2001/XMLSchema#string

Masahiro Aoki

http://www.w3.org/2001/XMLSchema#string

Masayuki Sudoh

http://www.w3.org/2001/XMLSchema#string

Michinori Kohara

http://www.w3.org/2001/XMLSchema#string

Mikio Arisawa

http://www.w3.org/2001/XMLSchema#string

Nobuo Shimma

http://www.w3.org/2001/XMLSchema#string

P2860

Interactions between viral nonstructural proteins and host protein hVAP-33 mediate the formation of hepatitis C virus RNA replication complex on lipid raft

Control of PKR protein kinase by hepatitis C virus nonstructural 5A protein: molecular mechanisms of kinase regulation.

Nonlinear partial differential equations and applications: Genomic analysis of the host response to hepatitis C virus infection

Hepatitis C Virus RNA Replication Occurs on a Detergent-Resistant Membrane That Cofractionates with Caveolin-2

Crystal structure of the RNA-dependent RNA polymerase from hepatitis C virus reveals a fully encircled active site

The crystal structure of hepatitis C virus NS3 proteinase reveals a trypsin-like fold and a structural zinc binding site

Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line

Functional rafts in cell membranes

Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group

Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis

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P304

333-337

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scholarly article

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10.1038/NCHEMBIO742

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6

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P478

1

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2005-10-16T00:00:00Z

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P698

16408072

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