Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
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Chronic suppression of acetyl-CoA carboxylase 1 in beta-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolismInsights into obesity and diabetes at the intersection of mouse and human geneticsSimilarity in Transcytosis of nNOSα in Enteric Nerve Terminals and Beta Cells of Pancreatic IsletShort-term cigarette smoke exposure induces reversible changes in energy metabolism and cellular redox status independent of inflammatory responses in mouse lungsPhylometabonomic patterns of adaptation to high fat diet feeding in inbred miceRole of the transcription factor sox4 in insulin secretion and impaired glucose tolerancePositional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in miceDerlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in miceThree-Dimensional Model of Human Nicotinamide Nucleotide Transhydrogenase (NNT) and Sequence-Structure Analysis of its Disease-Causing Variations.A comparative phenotypic and genomic analysis of C57BL/6J and C57BL/6N mouse strains.Analysis of gene expression in pancreatic islets from diet-induced obese mice.Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic beta-cell function.Electron transport chain-dependent and -independent mechanisms of mitochondrial H2O2 emission during long-chain fatty acid oxidation.Does reversible cysteine oxidation link the Western diet to cardiac dysfunction?The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways.Advantages of dynamic "closed loop" stable isotope flux phenotyping over static "open loop" clamps in detecting silent genetic and dietary phenotypes.Regulation of insulin secretion: role of mitochondrial signalling.Diet-induced obesity in two C57BL/6 substrains with intact or mutant nicotinamide nucleotide transhydrogenase (Nnt) geneMitochondrial dysfunction and increased reactive oxygen species impair insulin secretion in sphingomyelin synthase 1-null mice.Silencing of nicotinamide nucleotide transhydrogenase impairs cellular redox homeostasis and energy metabolism in PC12 cells.The C57BL/6J Mouse Strain Background Modifies the Effect of a Mutation in Bcl2l2A Comparative Study of the Metabolic and Skeletal Response of C57BL/6J and C57BL/6N Mice in a Diet-Induced Model of Type 2 DiabetesCofactor balance by nicotinamide nucleotide transhydrogenase (NNT) coordinates reductive carboxylation and glucose catabolism in the tricarboxylic acid (TCA) cycleDiabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects.Pancreatic islet expression profiling in diabetes-prone C57BLKS/J mice reveals transcriptional differences contributed by DBA loci, including Plagl1 and NntMitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.Molecular signature of MT1-MMP: transactivation of the downstream universal gene network in cancer.Differences in the degree of cerulein-induced chronic pancreatitis in C57BL/6 mouse substrains lead to new insights in identification of potential risk factors in the development of chronic pancreatitis.Differential colonization with segmented filamentous bacteria and Lactobacillus murinus do not drive divergent development of diet-induced obesity in C57BL/6 mice.Mitochondrial genetic background modulates bioenergetics and susceptibility to acute cardiac volume overload.Dysregulation of glucose homeostasis in nicotinamide nucleotide transhydrogenase knockout mice is independent of uncoupling protein 2.Mitochondrial energy metabolism and redox signaling in brain aging and neurodegenerationA microfluidic technique for monitoring bloodstream analytes indicative of C-peptide resistance in type 2 diabetes.Regulation of insulin synthesis and secretion and pancreatic Beta-cell dysfunction in diabetes.Mammalian NADH:ubiquinone oxidoreductase (Complex I) and nicotinamide nucleotide transhydrogenase (Nnt) together regulate the mitochondrial production of H₂O₂--implications for their role in disease, especially cancer.In-depth metabolic phenotyping of genetically engineered mouse models in obesity and diabetes.Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.High fat feeding unmasks variable insulin responses in male C57BL/6 mouse substrains.Methodological considerations when studying the skeletal response to glucose intolerance using the diet-induced obesity modelHow mice are indispensable for understanding obesity and diabetes genetics.
P2860
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P2860
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
2006年论文
@zh
2006年论文
@zh-cn
name
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
@en
type
label
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
@en
prefLabel
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
@en
P2093
P1433
P1476
Nicotinamide nucleotide transhydrogenase: a key role in insulin secretion.
@en
P2093
Emma Horner
Frances M Ashcroft
Helen Freeman
Kenju Shimomura
Roger D Cox
P356
10.1016/J.CMET.2005.10.008
P577
2006-01-01T00:00:00Z