Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.
about
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid productionPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseMimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analoguesPotent Sensitisation of Cancer Cells to Anticancer Drugs by a Quadruple Mutant of the Human Deoxycytidine KinaseSurvey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia.Deoxycytidine kinase augments ATM-Mediated DNA repair and contributes to radiation resistanceRegulation of deoxycytidine kinase expression and sensitivity to gemcitabine by micro-RNA 330 and promoter methylation in cancer cells.The apoptotic effects of toosendanin are partially mediated by activation of deoxycytidine kinase in HL-60 cellsTargeting DNA repair with aphidicolin sensitizes primary chronic lymphocytic leukemia cells to purine analogs.Deoxycytidine kinase regulates the G2/M checkpoint through interaction with cyclin-dependent kinase 1 in response to DNA damage.Phosphoprotein analysis: from proteins to proteomesNoninvasive prediction of tumor responses to gemcitabine using positron emission tomographyMechanistic studies on the synergistic cytotoxicity of the nucleoside analogs gemcitabine and clofarabine in multiple myeloma: relevance of p53 and its clinical implications.Fulfilling the Krebs and Beavo criteria for studying protein phosphorylation in the era of mass spectrometry-driven kinome research.Control of cell cycle progression by phosphorylation of cyclin-dependent kinase (CDK) substrates.Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.New insights into the synergism of nucleoside analogs with radiotherapyNucleoside Analog Activity in Malignant Melanoma Cell Lines.Protein phosphatase 2A regulates deoxycytidine kinase activity via Ser-74 dephosphorylation.Selenium mediated arsenic toxicity modifies cytotoxicity, reactive oxygen species and phosphorylated proteins.Identification of phosphorylated proteins involved in the oncogenesis of prostate cancer via Pin1-proteomic analysis.Influence of phosphorylation of THR-3, SER-11, and SER-15 on deoxycytidine kinase activity and stability.Identification of phosphorylation sites on human deoxycytidine kinase after overexpression in eucaryotic cells.Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function.ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.Probing the active site of the deoxynucleotide N-hydrolase Rcl encoded by the rat gene c6orf108.Bortezomib prevents cytarabine resistance in MCL, which is characterized by down-regulation of dCK and up-regulation of SPIB resulting in high NF-κB activity.
P2860
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P2860
Identification of in vivo phosphorylation sites on human deoxycytidine kinase. Role of Ser-74 in the control of enzyme activity.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Identification of in vivo phos ...... he control of enzyme activity.
@en
type
label
Identification of in vivo phos ...... he control of enzyme activity.
@en
prefLabel
Identification of in vivo phos ...... he control of enzyme activity.
@en
P2093
P2860
P356
P1476
Identification of in vivo phos ...... he control of enzyme activity.
@en
P2093
Caroline Smal
Eric Van Den Neste
Françoise Bontemps
Luc Bertrand
Mark H Rider
Sandrine Ntamashimikiro
P2860
P304
P356
10.1074/JBC.M512129200
P407
P577
2005-12-16T00:00:00Z