FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
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Proline-rich tyrosine kinase 2 (Pyk2) promotes proliferation and invasiveness of hepatocellular carcinoma cells through c-Src/ERK activationThe emerging role of FTY720 (Fingolimod) in cancer treatmentThe role of proline rich tyrosine kinase 2 (Pyk2) on cisplatin resistance in hepatocellular carcinomaSH3-domain binding protein 1 in the tumor microenvironment promotes hepatocellular carcinoma metastasis through WAVE2 pathwayAnticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.Down-regulation of S1P1 receptor surface expression by protein kinase C inhibition.S1P metabolism in cancer and other pathological conditions.Targeting inhibitors of the tumor suppressor PP2A for the treatment of pancreatic cancerFTY720 suppresses liver tumor metastasis by reducing the population of circulating endothelial progenitor cellsA garlic derivative, S-allylcysteine (SAC), suppresses proliferation and metastasis of hepatocellular carcinoma.Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular carcinoma.An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers.Fingolimod (FTY720) stimulates Ca(2+)/calcineurin signaling in fission yeast.Mouse model for probing tumor suppressor activity of protein phosphatase 2A in diverse signaling pathways.FTY720, a new alternative for treating blast crisis chronic myelogenous leukemia and Philadelphia chromosome-positive acute lymphocytic leukemia.Sphingolipid-based drugs selectively kill cancer cells by down-regulating nutrient transporter proteinsA critical role for Rac1 in tumor progression of human colorectal adenocarcinoma cellsFTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphomaSphingosine and FTY720 are potent inhibitors of the transient receptor potential melastatin 7 (TRPM7) channels.Current perspectives on FTY720.PP2A Counterbalances Phosphorylation of pRB and Mitotic Proteins by Multiple CDKs: Potential Implications for PP2A Disruption in CancerFTY720 inhibits tumor growth and enhances the tumor-suppressive effect of topotecan in neuroblastoma by interfering with the sphingolipid signaling pathwayProgrammed cell death 4 (PDCD4) suppresses metastastic potential of human hepatocellular carcinoma cells.Design, Synthesis, and Anti-leukemic Activity of Stereochemically Defined Constrained Analogs of FTY720 (Gilenya).Molecular therapy for the treatment of hepatocellular carcinoma.Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest.Tackling hepatitis B virus-associated hepatocellular carcinoma--the future is now.Protein phosphatase 2A: a target for anticancer therapy.The antineoplastic properties of FTY720: evidence for the repurposing of fingolimod.Azacyclic FTY720 Analogues That Limit Nutrient Transporter Expression but Lack S1P Receptor Activity and Negative Chronotropic Effects Offer a Novel and Effective Strategy to Kill Cancer Cells in Vivo.F-actin reorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration.Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism.Human mesenchymal stem cells overexpressing pigment epithelium-derived factor inhibit hepatocellular carcinoma in nude mice.The significance of proline-rich tyrosine kinase2 (Pyk2) on hepatocellular carcinoma progression and recurrence.Efficient inhibition of cisplatin-resistant human ovarian cancer growth and prolonged survival by gene transferred vesicular stomatitis virus matrix protein in nude mice.A genome-wide screen for FTY720-sensitive mutants reveals genes required for ROS homeostasis.FTY720 stimulated ROS generation and the Sty1/Atf1 signaling pathway in the fission yeast Schizosaccharomyces pombe.The protumorigenic potential of FTY720 by promoting extramedullary hematopoiesis and MDSC accumulation.More than Just an Immunosuppressant: The Emerging Role of FTY720 as a Novel Inducer of ROS and Apoptosis.
P2860
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P2860
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
@en
type
label
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
@en
prefLabel
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
@en
P2093
P1476
FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma.
@en
P2093
Alan C Chu
Chris K Sun
Hui Chuan Sun
Irene O Ng
Joanna W Ho
Kevin T Ng
Ronnie T P Poon
Sheung Tat Fan
P304
P356
10.1158/1078-0432.CCR-05-0447
P407
P577
2005-12-01T00:00:00Z