A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages.
about
Purinergic signalling and cancerThe role of purinergic signaling in the liver and in transplantation: effects of extracellular nucleotides on hepatic graft vascular injury, rejection and metabolismPolymorphisms in the P2X7 receptor gene are associated with low lumbar spine bone mineral density and accelerated bone loss in post-menopausal womenExpression and function of P2 receptors in hematopoietic stem and progenitor cellsInsights into the Molecular Mechanisms Underlying Mammalian P2X7 Receptor Functions and Contributions in Diseases, Revealed by Structural Modeling and Single Nucleotide PolymorphismsDetecting low frequent loss-of-function alleles in genome wide association studies with red hair color as exampleA common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular eventsCloning and pharmacological characterization of the guinea pig P2X7 receptor orthologueATP-induced autophagy is associated with rapid killing of intracellular mycobacteria within human monocytes/macrophagesCloning and pharmacological characterization of the dog P2X7 receptor.Year in review 2011: respiratory infections, tuberculosis, pleural diseases, bronchoscopic intervention and imagingMycobacterium tuberculosis, macrophages, and the innate immune response: does common variation matter?A putative extracellular salt bridge at the subunit interface contributes to the ion channel function of the ATP-gated P2X2 receptorEvidence for associations between the purinergic receptor P2X(7) (P2RX7) and toxoplasmosisThe role of the P2X₇ receptor in infectious diseases.P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages.The hyposensitive N187D P2X7 mutant promotes malignant progression in nude mice.Putative roles of purinergic signaling in human immunodeficiency virus-1 infectionThe purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor proteinThe second transmembrane domain of P2X7 contributes to dilated pore formationSingle-nucleotide polymorphisms in the P2X7 receptor gene are associated with post-menopausal bone loss and vertebral fracturesP2X receptor characterization and IL-1/IL-1Ra release from human endothelial cellsThe specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.P2X7-regulated protection from exacerbations and loss of control is independent of asthma maintenance therapy.Association Between P2RX7 Gene and Hepatocellular Carcinoma Susceptibility: A Case-Control Study in a Chinese Han PopulationUnresolved issues and controversies in purinergic signalling.Cell signaling via the P2X(7) nucleotide receptor: linkage to ROS production, gene transcription, and receptor traffickingPurinergic receptor-mediated effects of adenosine 5'-triphosphate in urological malignant diseases.The P2X(7) receptor and intracellular pathogens: a continuing struggle.Genetics of the P2X7 receptor and human disease.P2X(7) receptor at the heart of disease.The role of P2 receptors in controlling infections by intracellular pathogens.C terminus of the P2X7 receptor: treasure hunting.Purinergic signalling in the lower urinary tract.New insights into the interaction of Mycobacterium tuberculosis and human macrophages.Purinergic signalling and immune cells.Correlation between P2X7 receptor gene polymorphisms and gout.Investigation into the association between P2RX7 gene polymorphisms and susceptibility to primary gout and hyperuricemia in a Chinese Han male population.Canine erythrocytes express the P2X7 receptor: greatly increased function compared with human erythrocytes.P2X7 receptor activation mediates organic cation uptake into human myeloid leukaemic KG-1 cells.
P2860
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P2860
A Thr357 to Ser polymorphism in homozygous and compound heterozygous subjects causes absent or reduced P2X7 function and impairs ATP-induced mycobacterial killing by macrophages.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A Thr357 to Ser polymorphism i ...... terial killing by macrophages.
@en
type
label
A Thr357 to Ser polymorphism i ...... terial killing by macrophages.
@en
prefLabel
A Thr357 to Ser polymorphism i ...... terial killing by macrophages.
@en
P2093
P356
P1476
A Thr357 to Ser polymorphism i ...... terial killing by macrophages.
@en
P2093
Alison L Clarke
Anne N Shemon
Bernadette M Saunders
James S Wiley
Khai See Tan
Kristen K Skarratt
Lan-Phuong Dao-Ung
Stephen J Fuller
Steven Petrou
P304
P356
10.1074/JBC.M507816200
P407
P577
2005-11-01T00:00:00Z