Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
about
The macrophage: a therapeutic target in HIV-1 infectionModulation of NF-κB signalling by microbial pathogensFluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus.Cellular activation and intracellular HCV load in peripheral blood monocytes isolated from HCV monoinfected and HIV-HCV coinfected patientsRegulation of HIV-1 transcription in cells of the monocyte-macrophage lineage.Targeting TNF and TNF Receptor Pathway in HIV-1 Infection: from Immune Activation to Viral ReservoirsPatterns of HIV-1 protein interaction identify perturbed host-cellular subsystemsHIV-1 Vpr stimulates NF-κB and AP-1 signaling by activating TAK1.Vpr-host interactions during HIV-1 viral life cycle.JNK1 is required for lentivirus entry and gene transferHIV-1 accessory protein Vpr: relevance in the pathogenesis of HIV and potential for therapeutic interventionHIV-1 Vpr induces the degradation of ZIP and sZIP, adaptors of the NuRD chromatin remodeling complex, by hijacking DCAF1/VprBP.Differential regulation of NF-κB-mediated proviral and antiviral host gene expression by primate lentiviral Nef and Vpu proteins.Inhibition of NF-κB activity by HIV-1 Vpr is dependent on Vpr binding protein.Human immunodeficiency virus viral protein R as an extracellular protein in neuropathogenesis.Deployment of the human immunodeficiency virus type 1 protein arsenal: combating the host to enhance viral transcription and providing targets for therapeutic developmentHuman immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways.TNF and TNF receptor superfamily members in HIV infection: new cellular targets for therapy?Controversies in the pathogenesis of HIV-associated renal diseases.Cell-surface processing of extracellular human immunodeficiency virus type 1 Vpr by proprotein convertases.Macrophage signaling in HIV-1 infection.Limelight on two HIV/SIV accessory proteins in macrophage infection: is Vpx overshadowing Vpr?SLX4-SLX1 Protein-independent Down-regulation of MUS81-EME1 Protein by HIV-1 Viral Protein R (Vpr).Human Immunodeficiency Virus Infection and Host Defense in the Lungs.Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells.Primate Lentiviruses Modulate NF-κB Activity by Multiple Mechanisms to Fine-Tune Viral and Cellular Gene Expression.Primate lentiviruses use at least three alternative strategies to suppress NF-κB-mediated immune activation.Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes.HIV-1 Vpr protein activates the NF-κB pathway to promote G2/M cell cycle arrest.Virion-Associated Vpr Alleviates a Postintegration Block to HIV-1 Infection of Dendritic Cells.HIV-1 Vpr Inhibits Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication by Inducing MicroRNA miR-942-5p and Activating NF-κB SignalingSpecific amino acids in HIV-1 Vpr are significantly associated with differences in patient neurocognitive status.The HIV-1 Nef protein interacts with two components of the 40S small ribosomal subunit, the RPS10 protein and the 18S rRNA.T-Cell Signaling in HIV-1 Infection.HIV-1 Vpr induces TLR4/MyD88-mediated IL-6 production and reactivates viral production from latency.
P2860
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P2860
Synthetic Vpr protein activates activator protein-1, c-Jun N-terminal kinase, and NF-kappaB and stimulates HIV-1 transcription in promonocytic cells and primary macrophages.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Synthetic Vpr protein activate ...... cells and primary macrophages.
@en
type
label
Synthetic Vpr protein activate ...... cells and primary macrophages.
@en
prefLabel
Synthetic Vpr protein activate ...... cells and primary macrophages.
@en
P2093
P2860
P50
P356
P1476
Synthetic Vpr protein activate ...... cells and primary macrophages.
@en
P2093
Anne-Zélie Decrion
Audrey Varin
Bernard P Roques
Bharat B Aggarwal
Emmanuelle Sabbah
Georges Herbein
Joséphine Sire
Vincent Quivy
P2860
P304
42557-42567
P356
10.1074/JBC.M502211200
P407
P577
2005-10-21T00:00:00Z