Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1
about
The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.Cas mediates transcriptional activation of the serum response element by Src.Maintenance of the differentiated state in skeletal muscle: activation of v-Src disrupts sarcomeres in quail myotubes.v-Src-induced modulation of the calpain-calpastatin proteolytic system regulates transformation.Shp-2 mediates v-Src-induced morphological changes and activation of the anti-apoptotic protein kinase Akt.The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motilityTranslocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins.A mutant form of the rho protein can restore stress fibers and adhesion plaques in v-src transformed fibroblasts.
P2860
Q30168835-1E98CE86-56DB-4372-8432-5A2146036F91Q30175350-834AF90C-DFC3-43D0-949E-DF7656F883F3Q36382654-653AB4FC-C2D9-43D8-B3D5-654D5252AFDCQ39675981-F427DF41-2C1F-4D14-B312-42E0D8CC7BB1Q41751641-6BAE9719-39DC-4CFD-8876-C93E20BE864AQ42635431-679A0C3D-B7E0-44FB-A2F9-F858A5478645Q42803603-02A10178-8372-4DC8-8791-4CBB8BBA93DDQ45156955-8C878A35-4B15-4D63-9DAE-FB853342A600
P2860
Separation of v-Src-induced mitogenesis and morphological transformation by inhibition of AP-1
description
1994 nî lūn-bûn
@nan
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
1994年论文
@zh
1994年论文
@zh-cn
name
Separation of v-Src-induced mi ...... ormation by inhibition of AP-1
@en
type
label
Separation of v-Src-induced mi ...... ormation by inhibition of AP-1
@en
prefLabel
Separation of v-Src-induced mi ...... ormation by inhibition of AP-1
@en
P2093
P2860
P356
P1476
Separation of v-Src-induced mi ...... ormation by inhibition of AP-1
@en
P2093
P2860
P304
P356
10.1091/MBC.5.11.1177
P577
1994-11-01T00:00:00Z