The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
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NEDD9 stabilizes focal adhesions, increases binding to the extra-cellular matrix and differentially effects 2D versus 3D cell migrationSrc kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophilsInvolvement of the tyrosine kinase fer in cell adhesionThe MEK1 scaffolding protein MP1 regulates cell spreading by integrating PAK1 and Rho signals.SKI-606 (bosutinib), a novel Src kinase inhibitor, suppresses migration and invasion of human breast cancer cells.Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts.The Rho-mDia1 pathway regulates cell polarity and focal adhesion turnover in migrating cells through mobilizing Apc and c-SrcDifferential regulation of cell motility and invasion by FAKBeta2-adaptin binds actopaxin and regulates cell spreading, migration and matrix degradationThe spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imagingDystroglycan, Tks5 and Src mediated assembly of podosomes in myoblastsStructural insight into the mechanisms of targeting and signaling of focal adhesion kinase.The urokinase plasminogen activator receptor in the regulation of the actin cytoskeleton and cell motilitymDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber formationSRC-3Delta4 mediates the interaction of EGFR with FAK to promote cell migrationRegulation of fibroblast motility by the protein tyrosine phosphatase PTP-PESTmDia1 targets v-Src to the cell periphery and facilitates cell transformation, tumorigenesis, and invasionSpatiotemporal regulation of Src and its substrates at invadosomesSrc and FAK kinases cooperate to phosphorylate paxillin kinase linker, stimulate its focal adhesion localization, and regulate cell spreading and protrusiveness.SRC catalytic but not scaffolding function is needed for integrin-regulated tyrosine phosphorylation, cell migration, and cell spreading.The SH3 domain directs acto-myosin-dependent targeting of v-Src to focal adhesions via phosphatidylinositol 3-kinase.Wild-type and mutant forms of v-src differentially alter neuronal migration and differentiation in vivo.Requirement of a Src family kinase for initiating calcium release at fertilization in starfish eggs.Autophagy Promotes Focal Adhesion Disassembly and Cell Motility of Metastatic Tumor Cells through the Direct Interaction of Paxillin with LC3Decipher the dynamic coordination between enzymatic activity and structural modulation at focal adhesions in living cellsIntegrins in cell migrationTargeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cellsc-Abl is activated by growth factors and Src family kinases and has a role in the cellular response to PDGFRACK1 regulates integrin-mediated adhesion, protrusion, and chemotactic cell migration via its Src-binding siteRegulation of focal adhesion turnover by ErbB signalling in invasive breast cancer cells.Endosomal-sorting complexes required for transport (ESCRT) pathway-dependent endosomal traffic regulates the localization of active Src at focal adhesions.A biosensor generated via high-throughput screening quantifies cell edge Src dynamicsCCL2 disrupts the adherens junction: implications for neuroinflammationEngineering extrinsic disorder to control protein activity in living cells.FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migrationInsulin-like growth factor I controls adhesion strength mediated by alpha5beta1 integrins in motile carcinoma cells.Src-dependent ezrin phosphorylation in adhesion-mediated signalingInduced focal adhesion kinase (FAK) expression in FAK-null cells enhances cell spreading and migration requiring both auto- and activation loop phosphorylation sites and inhibits adhesion-dependent tyrosine phosphorylation of Pyk2.Mesenchymal migration as a therapeutic target in glioblastoma.Selected glimpses into the activation and function of Src kinase.
P2860
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P2860
The catalytic activity of Src is dispensable for translocation to focal adhesions but controls the turnover of these structures during cell motility
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
The catalytic activity of Src ...... tructures during cell motility
@en
The catalytic activity of Src ...... tructures during cell motility
@nl
type
label
The catalytic activity of Src ...... tructures during cell motility
@en
The catalytic activity of Src ...... tructures during cell motility
@nl
prefLabel
The catalytic activity of Src ...... tructures during cell motility
@en
The catalytic activity of Src ...... tructures during cell motility
@nl
P2860
P356
P1433
P1476
The catalytic activity of Src ...... tructures during cell motility
@en
P2093
P2860
P356
10.1093/EMBOJ/17.1.81
P407
P577
1998-01-01T00:00:00Z