SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation. - Wikidata - wikimedia - TriplyDB

SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.

SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.

http://www.wikidata.org/entity/Q40366547

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Evolution of JAK-STAT pathway components: mechanisms and role in immune system development Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor SOCS3: An essential physiological inhibitor of signaling by interleukin-6 and G-CSF family cytokines The role of suppressors of cytokine signalling in human neoplasms Insulin regulates SOCS2 expression and the mitogenic effect of IGF-1 in mesangial cells SOCS2 influences LPS induced human monocyte-derived dendritic cell maturation.A new polycythaemia vera-associated SOCS3 SH2 mutant (SOCS3F136L) cannot regulate erythropoietin responses Effects of High-Fat Feeding on Skeletal Muscle Gene Expression in Diabetic Goto-Kakizaki Rats Saponin inhibits hepatitis C virus propagation by up-regulating suppressor of cytokine signaling 2 t(8;9)(p22;p24)/PCM1-JAK2 activates SOCS2 and SOCS3 via STAT5.High expression of suppressor of cytokine signaling-2 predicts poor outcome in pediatric acute myeloid leukemia: a report from the Children's Oncology Group.Molecular signatures induced by interleukin-2 on peripheral blood mononuclear cells and T cell subsets SOCS2 regulates T helper type 2 differentiation and the generation of type 2 allergic responses.STAT5A-mediated SOCS2 expression regulates Jak2 and STAT3 activity following c-Src inhibition in head and neck squamous carcinoma A Point Mutation in Suppressor of Cytokine Signalling 2 (Socs2) Increases the Susceptibility to Inflammation of the Mammary Gland while Associated with Higher Body Weight and Size and Higher Milk Production in a Sheep Model.CD101 inhibits the expansion of colitogenic T cells.The SOCS box of suppressor of cytokine signaling-3 contributes to the control of G-CSF responsiveness in vivo.Polar opposites: Erk direction of CD4 T cell subsets.A novel viral SOCS from infectious spleen and kidney necrosis virus: interacts with Jak1 and inhibits IFN-α induced Stat1/3 activation.Regulation of multiple cytokine signalling pathways by SOCS3 is independent of SOCS2.Regulation of Macrophage, Dendritic Cell, and Microglial Phenotype and Function by the SOCS Proteins.SOCS2 is dispensable for BCR/ABL1-induced chronic myeloid leukemia-like disease and for normal hematopoietic stem cell function.Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2 Linked T cell receptor and cytokine signaling govern the development of the regulatory T cell repertoire.GH/STAT5 signaling during the growth period in livers of mice overexpressing GH.SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis SOCS3 tyrosine phosphorylation as a potential bio-marker for myeloproliferative neoplasms associated with mutant JAK2 kinases Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function.SOCS2 correlates with malignancy and exerts growth-promoting effects in prostate cancer.Leptin signaling: A key pathway in immune responses.Erythropoietin receptor response circuits Physical activity, immunity and infection.Regulation of CD4+ T-cell polarization by suppressor of cytokine signalling proteins.SOCS proteins in development and disease.Genetics of breast cancer bone metastasis: a sequential multistep pattern.Regulation of neurotrophin receptor (Trk) signaling: suppressor of cytokine signaling 2 (SOCS2) is a new player.Role of Ubiquitylation in Controlling Suppressor of Cytokine Signalling 3 (SOCS3) Function and Expression.Suppressor of cytokine signalling (SOCS) proteins as guardians of inflammatory responses critical for regulating insulin sensitivity.The C-terminus of CIS defines its interaction pattern.Absence of suppressor of cytokine signaling 2 turns cardiomyocytes unresponsive to LIF-dependent increases in Ca2+ levels.

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SOCS2 can enhance interleukin-2 (IL-2) and IL-3 signaling by accelerating SOCS3 degradation.

http://www.wikidata.org/entity/Q40366547

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2005 nî lūn-bûn

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SOCS2 can enhance interleukin- ...... ccelerating SOCS3 degradation.

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SOCS2 can enhance interleukin- ...... ccelerating SOCS3 degradation.

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SOCS2 can enhance interleukin- ...... ccelerating SOCS3 degradation.

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MCB.25.20.9115-9126.2005

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Molecular and Cellular Biology

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SOCS2 can enhance interleukin- ...... ccelerating SOCS3 degradation.

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Anna C Barry

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Gillian M Tannahill

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James A Johnston

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Joanne Elliott

http://www.w3.org/2001/XMLSchema#string

Linda Hibbert

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Nicolas A Cacalano

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P2860

A family of cytokine-inducible inhibitors of signalling

A new protein containing an SH2 domain that inhibits JAK kinases

Twenty proteins containing a C-terminal SOCS box form five structural classes

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

The Rbx1 subunit of SCF and VHL E3 ubiquitin ligase activates Rub1 modification of cullins Cdc53 and Cul2

Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein

The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation

Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex

Cytokine-inducible SH2 protein-3 (CIS3/SOCS3) inhibits Janus tyrosine kinase by binding through the N-terminal kinase inhibitory region as well as SH2 domain

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9115-9126

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10.1128/MCB.25.20.9115-9126.2005

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20

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25

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2005-10-01T00:00:00Z

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7565112

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16199887

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1265772

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