Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.
about
Novel cannabinoid receptorsIntegrating the puzzle pieces: the current atomistic picture of phospholipid-G protein coupled receptor interactionsStructural Characterization of an LPA1 Second Extracellular Loop Mimetic with a Self-Assembling Coiled-Coil Folding ConstraintStructural evidence of the species-dependent albumin binding of the modified cyclic phosphatidic acid with cytotoxic propertiesTargeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic painCyclic phosphatidic acid is produced by autotaxin in blood.Design and synthesis of sulfamoyl benzoic acid analogues with subnanomolar agonist activity specific to the LPA2 receptor.Aiming drug discovery at lysophosphatidic acid targets.Phospholipase D toxins of brown spider venom convert lysophosphatidylcholine and sphingomyelin to cyclic phosphatesThe phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulationCombined mitigation of the gastrointestinal and hematopoietic acute radiation syndromes by an LPA2 receptor-specific nonlipid agonist.FTY720 (Gilenya) phosphate selectivity of sphingosine 1-phosphate receptor subtype 1 (S1P1) G protein-coupled receptor requires motifs in intracellular loop 1 and transmembrane domain 2Lys39-Lysophosphatidate Carbonyl Oxygen Interaction Locks LPA1 N-terminal Cap to the Orthosteric Site and partners Arg124 During Receptor ActivationDual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivoInhibition of transcellular tumor cell migration and metastasis by novel carba-derivatives of cyclic phosphatidic acid.The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury.Mitigation of radiation injury by selective stimulation of the LPA(2) receptorVirtual screening for LPA2-specific agonists identifies a nonlipid compound with antiapoptotic actions.Carba analogs of cyclic phosphatidic acid are selective inhibitors of autotaxin and cancer cell invasion and metastasisIdentification of non-lipid LPA3 antagonists by virtual screening.Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins.Lysophospholipid interactions with protein targets.Cyclic phosphatidic acid - a unique bioactive phospholipid.Lysophosphatidic acid-induced platelet shape change revealed through LPA(1-5) receptor-selective probes and albumin.Lysophosphatidic acid-induced arterial wall remodeling: requirement of PPARgamma but not LPA1 or LPA2 GPCR.Anti-lysophosphatidic acid antibodies improve traumatic brain injury outcomes.Dissecting influenza virus pathogenesis uncovers a novel chemical approach to combat the infection.Molecular mechanisms of target recognition by lipid GPCRs: relevance for cancer.Release of cyclic phosphatidic acid from gelatin-based hydrogels inhibit colon cancer cell growth and migration.Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation.Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptorsSphingosine 1-phosphate pKa and binding constants: intramolecular and intermolecular influences.Toward the three-dimensional structure and lysophosphatidic acid binding characteristics of the LPA(4)/p2y(9)/GPR23 receptor: a homology modeling study.Lysophosphatidic Acid signals through specific lysophosphatidic Acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.Lipidomics in drug and biomarker development.Endogenous lysophosphatidic acid (LPA1 ) receptor agonists demonstrate ligand bias between calcium and ERK signalling pathways in human lung fibroblasts.Overexpression and Functional Stabilization of Recombinant Human Lysophosphatidic Acid Receptor 1 Using an Amphiphatic Polymer
P2860
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P2860
Identification of residues responsible for ligand recognition and regioisomeric selectivity of lysophosphatidic acid receptors expressed in mammalian cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Identification of residues res ...... expressed in mammalian cells.
@en
type
label
Identification of residues res ...... expressed in mammalian cells.
@en
prefLabel
Identification of residues res ...... expressed in mammalian cells.
@en
P2093
P2860
P356
P1476
Identification of residues res ...... expressed in mammalian cells.
@en
P2093
Abby Parrill
Akira Tokumura
Daniel Baker
Gabor Tigyi
Kimiko Murakami-Murofushi
Vineet Sardar
Yuko Fujiwara
P2860
P304
35038-35050
P356
10.1074/JBC.M504351200
P407
P577
2005-08-22T00:00:00Z