A novel polyclonal antibody specific for the Na(v)1.5 voltage-gated Na(+) channel 'neonatal' splice form.
about
Antibody therapeutics targeting ion channels: are we there yet?Multiple Nav1.5 isoforms are functionally expressed in the brain and present distinct expression patterns compared with cardiac Nav1.5.Alternative splicing of the cardiac sodium channel creates multiple variants of mutant T1620K channels.The neonatal splice variant of Nav1.5 potentiates in vitro invasive behaviour of MDA-MB-231 human breast cancer cells.A surface plasmon resonance approach to monitor toxin interactions with an isolated voltage-gated sodium channel paddle motif.Alternative splicing modulates inactivation of type 1 voltage-gated sodium channels by toggling an amino acid in the first S3-S4 linker.Developmentally regulated SCN5A splice variant potentiates dysfunction of a novel mutation associated with severe fetal arrhythmiaFGFR1 cleavage and nuclear translocation regulates breast cancer cell behavior.An emerging role for voltage-gated Na+ channels in cellular migration: regulation of central nervous system development and potentiation of invasive cancersA novel adhesion molecule in human breast cancer cells: voltage-gated Na+ channel beta1 subunit.Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic functionBiology of cardiac sodium channel Nav1.5 expression.Immunopharmacology: utilizing antibodies as ion channel modulators.Neurological perspectives on voltage-gated sodium channels.Cardiac sodium channelopathy associated with SCN5A mutations: electrophysiological, molecular and genetic aspects.New horizons in therapeutic antibody discovery: opportunities and challenges versus small-molecule therapeutics.Sigma-1 receptors modulate neonatal Nav1.5 ion channels in breast cancer cell lines.In vitro effects of phenytoin and DAPT on MDA-MB-231 breast cancer cells.Production of a specific extracellular inhibitor of TRPM3 channels.Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A.Nerve growth factor enhances voltage-gated Na+ channel activity and Transwell migration in Mat-LyLu rat prostate cancer cell line.Nav channel binder containing a specific conjugation-site based on a low toxicity β-scorpion toxin.Expression of voltage-gated sodium channel Nav1.5 in non-metastatic colon cancer and its associations with estrogen receptor (ER)-β expression and clinical outcomes.Molecular expression of multiple Nav1.5 splice variants in the frontal lobe of the human brain.'Neonatal' Nav1.2 reduces neuronal excitability and affects seizure susceptibility and behaviour.Polarised localisation of the voltage-gated sodium channel Na(v)1.2 in cerebellar granule cells.Electrophysiological and developmental implications of Na+ channel-splice variants.Immuno-Oncology: Emerging Targets and Combination Therapies
P2860
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P2860
A novel polyclonal antibody specific for the Na(v)1.5 voltage-gated Na(+) channel 'neonatal' splice form.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A novel polyclonal antibody sp ...... hannel 'neonatal' splice form.
@en
type
label
A novel polyclonal antibody sp ...... hannel 'neonatal' splice form.
@en
prefLabel
A novel polyclonal antibody sp ...... hannel 'neonatal' splice form.
@en
P2093
P1476
A novel polyclonal antibody sp ...... hannel 'neonatal' splice form.
@en
P2093
Athina-Myrto Chioni
Filippo Pani
Graham P Wilkin
James K J Diss
Mustafa B A Djamgoz
Patrick Foran
Scott P Fraser
P356
10.1016/J.JNEUMETH.2005.03.010
P577
2005-09-01T00:00:00Z