The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
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Cancer Stem Cell Hierarchy in Glioblastoma MultiformeGEMMs as preclinical models for testing pancreatic cancer therapiesMouse models of pancreatic cancerUtilizing past and present mouse systems to engineer more relevant pancreatic cancer modelsAssessing tumor progression factors by somatic gene transfer into a mouse model: Bcl-xL promotes islet tumor cell invasion.Activation of PyMT in beta cells induces irreversible hyperplasia, but oncogene-dependent acinar cell carcinomas when activated in pancreatic progenitors.Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancerGene targeting to the stroma of the prostate and bone.Accelerating cancer modeling with RNAi and nongermline genetically engineered mouse models.PDX-1: demonstration of oncogenic properties in pancreatic cancer.In vivo disruption of TGF-beta signaling by Smad7 leads to premalignant ductal lesions in the pancreasIntroduction of oncogenes into mammary glands in vivo with an avian retroviral vector initiates and promotes carcinogenesis in mouse models.N-cadherin and keratinocyte growth factor receptor mediate the functional interplay between Ki-RASG12V and p53V143A in promoting pancreatic cell migration, invasion, and tissue architecture disruption.Inactivation of Brca2 promotes Trp53-associated but inhibits KrasG12D-dependent pancreatic cancer development in mice.Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma.Lessons in signaling and tumorigenesis from polyomavirus middle T antigen.Characterization of pancreatic lesions from MT-tgf alpha, Ela-myc and MT-tgf alpha/Ela-myc single and double transgenic miceDifferential sensitivity of mouse epithelial tissues to the polyomavirus middle T oncogene.Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis.Disruption and inactivation of the PP2A complex promotes the proliferation and angiogenesis of hemangioma endothelial cells through activating AKT and ERK.Study human pancreatic cancer in mice: how close are they?Dormant cancer cells contribute to residual disease in a model of reversible pancreatic cancer.Lentivirus-mediated oncogene introduction into mammary cells in vivo induces tumors.Histological complexities of pancreatic lesions from transgenic mouse models are consistent with biological and morphological heterogeneity of human pancreatic cancer.A Cre-loxP-based mouse model for conditional somatic gene expression and knockdown in vivo by using avian retroviral vectors.Progressive metaplastic and dysplastic changes in mouse pancreas induced by cyclooxygenase-2 overexpression.Cell-specific transduction of Prdm1-expressing lineages mediated by a receptor for avian leukosis virus subgroup Bp53 and p16Ink4a/p19Arf Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor CellsLessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer.Challenges and advances in mouse modeling for human pancreatic tumorigenesis and metastasisActivation of WNT/β-Catenin Signaling Enhances Pancreatic Cancer Development and the Malignant Potential Via Up-regulation of Cyr61.Activated wnt signaling in stroma contributes to development of pancreatic mucinous cystic neoplasms.Pancreatic cancer: gene therapy approaches and gene delivery systems.KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling.Pancreatic ductal adenocarcinoma and transcription factors: role of c-Myc.Recent developments of transgenic and xenograft mouse models of pancreatic cancer for translational research.MYC-y mice: from tumour initiation to therapeutic targeting of endogenous MYC.Loss of p53 and Ink4a/Arf cooperate in a cell autonomous fashion to induce metastasis of hepatocellular carcinoma cells.Deubiquitinase USP13 maintains glioblastoma stem cells by antagonizing FBXL14-mediated Myc ubiquitination.Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells.
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P2860
The c-myc and PyMT oncogenes induce different tumor types in a somatic mouse model for pancreatic cancer
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
The c-myc and PyMT oncogenes i ...... se model for pancreatic cancer
@en
type
label
The c-myc and PyMT oncogenes i ...... se model for pancreatic cancer
@en
prefLabel
The c-myc and PyMT oncogenes i ...... se model for pancreatic cancer
@en
P2860
P356
P1433
P1476
The c-myc and PyMT oncogenes i ...... se model for pancreatic cancer
@en
P2093
Brian C Lewis
David S Klimstra
P2860
P304
P356
10.1101/GAD.1140403
P577
2003-12-17T00:00:00Z