Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.
about
The small GTPase Rac3 interacts with the integrin-binding protein CIB and promotes integrin alpha(IIb)beta(3)-mediated adhesion and spreadingType I PIPK-alpha regulates directed cell migration by modulating Rac1 plasma membrane targeting and activationMYADM regulates Rac1 targeting to ordered membranes required for cell spreading and migration.Rac1-induced cell migration requires membrane recruitment of the nuclear oncogene SETA palmitoylation switch mechanism regulates Rac1 function and membrane organization.Targeting and activation of Rac1 are mediated by the exchange factor beta-Pix.Pak1 regulates branching morphogenesis in 3D MDCK cell culture by a PIX and beta1-integrin-dependent mechanismCAP interacts with cytoskeletal proteins and regulates adhesion-mediated ERK activation and motilityPak1 and PIX regulate contact inhibition during epithelial wound healingAffixin activates Rac1 via betaPIX in C2C12 myoblastRecruitment of the Arp2/3 complex to vinculin: coupling membrane protrusion to matrix adhesionScrib regulates PAK activity during the cell migration processVE-cadherin regulates endothelial actin activating Rac and increasing membrane association of TiamTyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling.RhoGDI: multiple functions in the regulation of Rho family GTPase activitiesHIV-1 Tat regulates endothelial cell cycle progression via activation of the Ras/ERK MAPK signaling pathwayGrowth control by intracellular tension and extracellular stiffnessEndogenous RhoG is dispensable for integrin-mediated cell spreading but contributes to Rac-independent migration.P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migrationGTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivoRho GTPases, phosphoinositides, and actin: a tripartite framework for efficient vesicular traffickingThe role of p21-activated kinases in hepatocellular carcinoma metastasisPhosphorylation of tyrosine 285 of PAK1 facilitates βPIX/GIT1 binding and adhesion turnoverHomologues of oxysterol-binding proteins affect Cdc42p- and Rho1p-mediated cell polarization in Saccharomyces cerevisiae.The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activityPAK1 phosphorylation of MEK1 regulates fibronectin-stimulated MAPK activationLaminin-10/11 and fibronectin differentially regulate integrin-dependent Rho and Rac activation via p130(Cas)-CrkII-DOCK180 pathwayBasic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathwayAkt phosphorylation of serine 21 on Pak1 modulates Nck binding and cell migrationSH2-Bbeta is a Rac-binding protein that regulates cell motilityActivation of p21-activated kinase 1 is required for lysophosphatidic acid-induced focal adhesion kinase phosphorylation and cell motility in human melanoma A2058 cellsActivation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentSHPS-1 regulates integrin-mediated cytoskeletal reorganization and cell motilityModulation of Rac localization and function by dynamin.Effects of cell tension on the small GTPase RacAdhesion stimulates direct PAK1/ERK2 association and leads to ERK-dependent PAK1 Thr212 phosphorylationTrkB-mediated activation of geranylgeranyltransferase I promotes dendritic morphogenesisPromyelocytic leukemia (PML) protein plays important roles in regulating cell adhesion, morphology, proliferation and migrationAlpha-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signallingRegulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
P2860
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P2860
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAK.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh
2000年學術文章
@zh-hant
name
Adhesion to the extracellular ...... TPase Rac to its effector PAK.
@en
type
label
Adhesion to the extracellular ...... TPase Rac to its effector PAK.
@en
prefLabel
Adhesion to the extracellular ...... TPase Rac to its effector PAK.
@en
P2093
P2860
P356
P1433
P1476
Adhesion to the extracellular ...... GTPase Rac to its effector PAK
@en
P2093
P2860
P304
P356
10.1093/EMBOJ/19.9.2008
P407
P577
2000-05-01T00:00:00Z