SH2-Bbeta is a Rac-binding protein that regulates cell motility
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SH2-B is required for both male and female reproductionMembrane ruffling requires coordination between type Ialpha phosphatidylinositol phosphate kinase and Rac signalingJAK2 tyrosine kinase phosphorylates PAK1 and regulates PAK1 activity and functionsTyrosine 813 is a site of JAK2 autophosphorylation critical for activation of JAK2 by SH2-B betaPAK1-Nck regulates cyclin D1 promoter activity in response to prolactinSH2B1 regulation of energy balance, body weight, and glucose metabolism.Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.YXXL motifs in SH2-Bbeta are phosphorylated by JAK2, JAK1, and platelet-derived growth factor receptor and are required for membrane ruffling.Growth hormone signal transduction.Phosphorylation controls a dual-function polybasic nuclear localization sequence in the adapter protein SH2B1β to regulate its cellular function and distributionAdapter protein SH2B1beta binds filamin A to regulate prolactin-dependent cytoskeletal reorganization and cell motility.Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.Adapter protein SH2-Bbeta stimulates actin-based motility of Listeria monocytogenes in a vasodilator-stimulated phosphoprotein (VASP)-dependent fashion.Genome-wide association study revealed genomic regions related to white/red earlobe color trait in the Rhode Island Red chickensHuman SH2B1 mutations are associated with maladaptive behaviors and obesity.MicroRNA-361-3p suppresses tumor cell proliferation and metastasis by directly targeting SH2B1 in NSCLC.Phosphorylation of the adaptor protein SH2B1β regulates its ability to enhance growth hormone-dependent macrophage motilityAdapter protein SH2B1beta cross-links actin filaments and regulates actin cytoskeletonResearch resource: identification of novel growth hormone-regulated phosphorylation sites by quantitative phosphoproteomics.The Lnk adaptor protein: a key regulator of normal and pathological hematopoiesis.Adapter protein SH2-B beta undergoes nucleocytoplasmic shuttling: implications for nerve growth factor induction of neuronal differentiation.Src-CrkII-C3G-dependent activation of Rap1 switches growth hormone-stimulated p44/42 MAP kinase and JNK/SAPK activities.RhoA/ROCK activation by growth hormone abrogates p300/histone deacetylase 6 repression of Stat5-mediated transcription.Diversity in peptide recognition by the SH2 domain of SH2B1.SH2B1 promotes epithelial-mesenchymal transition through the IRS1/β-catenin signaling axis in lung adenocarcinoma.
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SH2-Bbeta is a Rac-binding protein that regulates cell motility
description
2002 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի մարտին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2002
@ast
im März 2002 veröffentlichter wissenschaftlicher Artikel
@de
scientific article (publication date: 22 March 2002)
@en
vedecký článok (publikovaný 2002/03/22)
@sk
vědecký článek publikovaný v roce 2002
@cs
wetenschappelijk artikel (gepubliceerd op 2002/03/22)
@nl
наукова стаття, опублікована в березні 2002
@uk
name
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@ast
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@en
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@nl
type
label
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@ast
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@en
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@nl
prefLabel
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@ast
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@en
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@nl
P2093
P2860
P3181
P356
P1476
SH2-Bbeta is a Rac-binding protein that regulates cell motility
@en
P2093
Christin Carter-Su
David R Gunter
James Herrington
P2860
P304
P3181
P356
10.1074/JBC.M111138200
P407
P577
2002-03-22T00:00:00Z