Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.
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A protease-independent function for SPPL3 in NFAT activationNuclear signalling by tumour-associated antigen EpCAMGAB2 alleles modify Alzheimer's risk in APOE epsilon4 carriersLysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutationsAlzheimer's disease phenotypes and genotypes associated with mutations in presenilin 2.Accumulation of phosphorylated beta-catenin enhances ROS-induced cell death in presenilin-deficient cellsA fragment of the scaffolding protein RanBP9 is increased in Alzheimer's disease brains and strongly potentiates amyloid-beta peptide generation.Presenilin 2 is the predominant γ-secretase in microglia and modulates cytokine releaseGain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.Modeling presenilin-dependent familial Alzheimer's disease: emphasis on presenilin substrate-mediated signaling and synaptic function.Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's diseaseTranscriptional regulation of PEN-2, a key component of the gamma-secretase complex, by CREBThe γ-secretase complex: from structure to function.Telencephalin protects PAJU cells from amyloid beta protein-induced apoptosis by activating the ezrin/radixin/moesin protein family/phosphatidylinositol-3-kinase/protein kinase B pathway.Pathological and physiological functions of presenilins.Power and pitfalls of the genome-wide association study approach to identify genes for Alzheimer's disease.Presenilin 1 regulates homeostatic synaptic scaling through Akt signaling.p53-dependent control of transactivation of the Pen2 promoter by presenilinsPresenilins regulate the cellular level of the tumor suppressor PTEN.Presenilin mutations linked to familial Alzheimer's disease cause an imbalance in phosphatidylinositol 4,5-bisphosphate metabolism.Moonlighting activity of presenilin in plants is independent of gamma-secretase and evolutionarily conserved.Mechanisms of AD neurodegeneration may be independent of Aβ and its derivatives.The role of presenilin and its interacting proteins in the biogenesis of Alzheimer's beta amyloidCritical role of presenilin-dependent γ-secretase activity in DNA damage-induced promyelocytic leukemia protein expression and apoptosis.Interactome analyses of mature γ-secretase complexes reveal distinct molecular environments of presenilin (PS) paralogs and preferential binding of signal peptide peptidase to PS2.Cortical development in the presenilin-1 null mutant mouse fails after splitting of the preplate and is not due to a failure of reelin-dependent signalingCell signaling abnormalities may drive neurodegeneration in familial Alzheimer diseaseGenetic dissection of gamma-secretase-dependent and -independent functions of presenilin in regulating neuronal cell cycle and cell death.Notch1 hallmarks fibrillary depositions in sporadic Alzheimer's disease.Alzheimer's disease sends the wrong signals--a perspective.gamma-Secretase: a multifaceted regulator of angiogenesisPresenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulationUV irradiation accelerates amyloid precursor protein (APP) processing and disrupts APP axonal transport.Are Abeta and its derivatives causative agents or innocent bystanders in AD?Amyloid-independent mechanisms in Alzheimer's disease pathogenesisp53, a pivotal effector of a functional cross-talk linking presenilins and Pen-2.Molecular consequences of amyloid precursor protein and presenilin mutations causing autosomal-dominant Alzheimer's diseaseNeurodegeneration in Alzheimer disease: role of amyloid precursor protein and presenilin 1 intracellular signaling.EpCAM and its potential role in tumor-initiating cells.Pericytes of the neurovascular unit: key functions and signaling pathways.
P2860
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P2860
Presenilins mediate phosphatidylinositol 3-kinase/AKT and ERK activation via select signaling receptors. Selectivity of PS2 in platelet-derived growth factor signaling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
Presenilins mediate phosphatid ...... rived growth factor signaling.
@en
type
label
Presenilins mediate phosphatid ...... rived growth factor signaling.
@en
prefLabel
Presenilins mediate phosphatid ...... rived growth factor signaling.
@en
P2093
P356
P1476
Presenilins mediate phosphatid ...... erived growth factor signaling
@en
P2093
David E Kang
Edward H Koo
Il Sang Yoon
Nader Yermian
Tracy Busse
P304
31537-31547
P356
10.1074/JBC.M500833200
P407
P577
2005-07-13T00:00:00Z