Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons. - Wikidata - wikimedia - TriplyDB

Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

http://www.wikidata.org/entity/Q33966472

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A protease-independent function for SPPL3 in NFAT activation Role of presenilin 1 in structural plasticity of cortical dendritic spines in vivo Mitochondria-associated membranes as hubs for neurodegeneration A Low Affinity GCaMP3 Variant (GCaMPer) for Imaging the Endoplasmic Reticulum Calcium Store Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime Analyzing dendritic spine pathology in Alzheimer's disease: problems and opportunities Development and implementation of a high-throughput compound screening assay for targeting disrupted ER calcium homeostasis in Alzheimer's disease Calpain-cleaved type 1 inositol 1,4,5-trisphosphate receptor (InsP(3)R1) has InsP(3)-independent gating and disrupts intracellular Ca(2+) homeostasis Long-term dantrolene treatment reduced intraneuronal amyloid in aged Alzheimer triple transgenic mice Suppression of InsP3 receptor-mediated Ca2+ signaling alleviates mutant presenilin-linked familial Alzheimer's disease pathogenesis.Homeostatic disinhibition in the aging brain and Alzheimer's disease Mutagenesis mapping of the presenilin 1 calcium leak conductance pore.Inositol trisphosphate receptor Ca2+ release channels in neurological diseases.NMDA-mediated Ca(2+) influx drives aberrant ryanodine receptor activation in dendrites of young Alzheimer's disease mice.Early calcium dysregulation in Alzheimer's disease: setting the stage for synaptic dysfunction.The C terminus of Bax inhibitor-1 forms a Ca2+-permeable channel pore.Stabilizing ER Ca2+ channel function as an early preventative strategy for Alzheimer's disease.Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease Novel mechanism of increased Ca2+ release following oxidative stress in neuronal cells involves type 2 inositol-1,4,5-trisphosphate receptors.Presenilin 2 modulates endoplasmic reticulum (ER)-mitochondria interactions and Ca2+ cross-talk.General anesthetic isoflurane modulates inositol 1,4,5-trisphosphate receptor calcium channel opening.Membrane Incorporation, Channel Formation, and Disruption of Calcium Homeostasis by Alzheimer's β-Amyloid Protein.ER calcium and Alzheimer's disease: in a state of flux.Endoplasmic reticulum oxidoreductin-1-like β (ERO1lβ) regulates susceptibility to endoplasmic reticulum stress and is induced by insulin flux in β-cells.Endoplasmic reticulum Ca(2+) handling in excitable cells in health and disease Constitutive cAMP response element binding protein (CREB) activation by Alzheimer's disease presenilin-driven inositol trisphosphate receptor (InsP3R) Ca2+ signaling.Presenilin-like GxGD membrane proteases have dual roles as proteolytic enzymes and ion channels.The Ca(2+) channel inhibitor 2-APB reverses β-amyloid-induced LTP deficit in hippocampus by blocking BAX and caspase-3 hyperactivation Inositol 1,4,5-trisphosphate receptors in the endoplasmic reticulum: A single-channel point of view.Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer's Disease-Causing Mutants in Presenilins.Lack of evidence for presenilins as endoplasmic reticulum Ca2+ leak channels Mitochondrial Ca(2+) and neurodegeneration Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer's disease mice.Reduction of increased calcineurin activity rescues impaired homeostatic synaptic plasticity in presenilin 1 M146V mutant.Upregulated function of mitochondria-associated ER membranes in Alzheimer disease Role of endoplasmic reticulum Ca2+ signaling in the pathogenesis of Alzheimer disease Emergence of ion channel modal gating from independent subunit kinetics.Involvement of presenilin holoprotein upregulation in calcium dyshomeostasis of Alzheimer's disease.Presenilins regulate the cellular activity of ryanodine receptors differentially through isotype-specific N-terminal cysteines.Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca(2+) disruptions.

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Gain-of-function enhancement of IP3 receptor modal gating by familial Alzheimer's disease-linked presenilin mutants in human cells and mouse neurons.

http://www.wikidata.org/entity/Q33966472

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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Gain-of-function enhancement o ...... human cells and mouse neurons.

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Gain-of-function enhancement o ...... human cells and mouse neurons.

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Gain-of-function enhancement o ...... human cells and mouse neurons.

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Gain-of-function enhancement o ...... human cells and mouse neurons.

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David E Kang

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Don-On Daniel Mak

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Ikuo Hayashi

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J Kevin Foskett

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King-Ho Cheung

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Lijuan Mei

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Takeshi Iwatsubo

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P2860

Presenilins form ER Ca2+ leak channels, a function disrupted by familial Alzheimer's disease-linked mutations

Familial Alzheimer disease-linked mutations specifically disrupt Ca2+ leak function of presenilin 1

Hidden Markov modeling for single channel kinetics with filtering and correlated noise

Pathways towards and away from Alzheimer's disease

The presenilins

The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics

Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid beta-peptide

Presenilin 1 facilitates the constitutive turnover of beta-catenin: differential activity of Alzheimer's disease-linked PS1 mutants in the beta-catenin-signaling pathway

Presenilin couples the paired phosphorylation of beta-catenin independent of axin: implications for beta-catenin activation in tumorigenesis

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

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Alzheimer's disease

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2898196

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