A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2).
about
Molecular determinants of substrate selectivity of a novel organic cation transporter (PMAT) in the SLC29 familyPutative transmembrane domain 12 of the human organic anion transporter hOAT1 determines transporter stability and maturation efficiency.Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2Structure and function of the reduced folate carrier a paradigm of a major facilitator superfamily mammalian nutrient transporter.Homology modeling of GLUT4, an insulin regulated facilitated glucose transporter and docking studies with ATP and its inhibitors.Differences in the substrate binding regions of renal organic anion transporters 1 (OAT1) and 3 (OAT3)Identification of functional amino acid residues involved in polyamine and agmatine transport by human organic cation transporter 2A three-dimensional model of human organic anion transporter 1: aromatic amino acids required for substrate transport.Functional significance of conserved cysteines in the human organic cation transporter 2.Role of a Hydrophobic Pocket in Polyamine Interactions with the Polyspecific Organic Cation Transporter OCT3Polyamine transport by the polyspecific organic cation transporters OCT1, OCT2, and OCT3Eukaryotic major facilitator superfamily transporter modeling based on the prokaryotic GlpT crystal structure.Future directions for drug transporter modelling.Substrate-dependent ligand inhibition of the human organic cation transporter OCT2.The organic cation transporter, OCTN1, expressed in the human heart, potentiates antagonism of the HERG potassium channelAnalysis of a large cluster of SLC22 transporter genes, including novel USTs, reveals species-specific amplification of subsets of family membersMATE1 has an external COOH terminus, consistent with a 13-helix topology.Multiple mechanisms of ligand interaction with the human organic cation transporter, OCT2Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition.Renal transport of organic anions and cations.Unstirred Water Layers and the Kinetics of Organic Cation Transport.Lack of Influence of Substrate on Ligand Interaction with the Human Multidrug and Toxin Extruder, MATE1.A substrate binding hinge domain is critical for transport-related structural changes of organic cation transporter 1The chloride dependence of the human organic anion transporter 1 (hOAT1) is blunted by mutation of a single amino acid.Identification of a novel inhibition site in translocase MraY based upon the site of interaction with lysis protein E from bacteriophage ϕX174.Functional influence of N-glycosylation in OCT2-mediated tetraethylammonium transport.Genetic variants of organic cation transporter 1 (OCT1) and OCT2 significantly reduce lamivudine uptake.Identification of cysteines in rat organic cation transporters rOCT1 (C322, C451) and rOCT2 (C451) critical for transport activity and substrate affinity.Inorganic mercury interacts with cysteine residues (C451 and C474) of hOCT2 to reduce its transport activity.Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
P2860
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P2860
A conserved glutamate residue in transmembrane helix 10 influences substrate specificity of rabbit OCT2 (SLC22A2).
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
2005年论文
@zh
2005年论文
@zh-cn
name
A conserved glutamate residue ...... city of rabbit OCT2 (SLC22A2).
@en
type
label
A conserved glutamate residue ...... city of rabbit OCT2 (SLC22A2).
@en
prefLabel
A conserved glutamate residue ...... city of rabbit OCT2 (SLC22A2).
@en
P2093
P2860
P356
P1476
A conserved glutamate residue ...... city of rabbit OCT2 (SLC22A2).
@en
P2093
Daruka Mahadevan
Nikhil V Shirahatti
Stephen H Wright
Xiaohong Zhang
P2860
P304
34813-34822
P356
10.1074/JBC.M506342200
P407
P577
2005-08-08T00:00:00Z