Janus kinases affect thrombopoietin receptor cell surface localization and stability. - Wikidata - wikimedia - TriplyDB

Janus kinases affect thrombopoietin receptor cell surface localization and stability.

Janus kinases affect thrombopoietin receptor cell surface localization and stability.

http://www.wikidata.org/entity/Q40420997

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Mpl traffics to the cell surface through conventional and unconventional routes Suppressor of cytokine signaling 3 controls lysosomal routing of G-CSF receptor Basal ubiquitin-independent internalization of interferon alpha receptor is prevented by Tyk2-mediated masking of a linear endocytic motif Nuclear Jak2 and transcription factor NF1-C2: a novel mechanism of prolactin signaling in mammary epithelial cells JAK kinase targeting in hematologic malignancies: a sinuous pathway from identification of genetic alterations towards clinical indications Targeting JAK2 in the therapy of myeloproliferative neoplasms Integrating non-coding RNAs in JAK-STAT regulatory networks Jak2 is a negative regulator of ubiquitin-dependent endocytosis of the growth hormone receptor Characterization of a patient with atypical amegakaryocytic thrombocytopenia.Dynamin 2-dependent endocytosis is required for normal megakaryocyte development in mice.The Thrombopoietin Receptor: Structural Basis of Traffic and Activation by Ligand, Mutations, Agonists, and Mutated Calreticulin.Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies.JAK2 V617F constitutive activation requires JH2 residue F595: a pseudokinase domain target for specific inhibitors Pathological interactions between hematopoietic stem cells and their niche revealed by mouse models of primary myelofibrosis.Structural basis of recognition of interferon-α receptor by tyrosine kinase 2 An N-ethyl-N-nitrosourea (ENU)-induced dominant negative mutation in the JAK3 kinase protects against cerebral malaria JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.The Jak/STAT signaling pathway is downregulated at febrile temperatures.Targeting the JAK-STAT pathway in lymphoma: a focus on pacritinib.Transcriptional control of adrenal steroidogenesis: novel connection between Janus kinase (JAK) 2 protein and protein kinase A (PKA) through stabilization of cAMP response element-binding protein (CREB) transcription factor.Molecular mimicry in the chronic myeloproliferative disorders: reciprocity between quantitative JAK2 V617F and Mpl expression Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells.Crystal Structure of the FERM-SH2 Module of Human Jak2.The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenes The role of Janus kinases in haemopoiesis and haematological malignancy.His499 Regulates Dimerization and Prevents Oncogenic Activation by Asparagine Mutations of the Human Thrombopoietin Receptor Tryptophan at the transmembrane-cytosolic junction modulates thrombopoietin receptor dimerization and activation.YRRL motifs in the cytoplasmic domain of the thrombopoietin receptor regulate receptor internalization and degradation.Update on the impact of the JAK2 mutation on signalling pathways in myeloproliferative disorders.Phenotype and genotype in the myeloproliferative disorders.The Structural Basis for Class II Cytokine Receptor Recognition by JAK1 Regulation of prolactin receptor levels and activity in breast cancer Ligand-independent thrombopoietin mutant receptor requires cell surface localization for endogenous activity.Modulation of growth hormone receptor abundance and function: roles for the ubiquitin-proteasome system.Eliminative signaling by Janus kinases: role in the downregulation of associated receptors.A JAK2 interdomain linker relays Epo receptor engagement signals to kinase activation Perspectives for the use of structural information and chemical genetics to develop inhibitors of Janus kinases JAK2 inhibitors: what's the true therapeutic potential?Molecular Pathogenesis and Clinical Significance of Driver Mutations in Primary Myelofibrosis: A Review Phosphorylated c-Mpl tyrosine 591 regulates thrombopoietin-induced signaling.

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P2860

Janus kinases affect thrombopoietin receptor cell surface localization and stability.

http://www.wikidata.org/entity/Q40420997

description

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2005年の論文

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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Janus kinases affect thrombopoietin receptor cell surface localization and stability.

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Janus kinases affect thrombopoietin receptor cell surface localization and stability.

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Janus kinases affect thrombopoietin receptor cell surface localization and stability.

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Journal of Biological Chemistry

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Janus kinases affect thrombopoietin receptor cell surface localization and stability.

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P2093

Judith Staerk

http://www.w3.org/2001/XMLSchema#string

Marcel Costuleanu

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Pierre J Courtoy

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Yohan Royer

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P2860

Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

Tight control of gene expression in mammalian cells by tetracycline-responsive promoters

Dissecting the thrombopoietin receptor: functional elements of the Mpl cytoplasmic domain

Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase

The amino-terminal region of Tyk2 sustains the level of interferon alpha receptor 1, a component of the interferon alpha/beta receptor

Thrombopoietin signal transduction requires functional JAK2, not TYK2

Mapping of a region within the N terminus of Jak1 involved in cytokine receptor interaction

The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor

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27251-27261

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scholarly article

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10.1074/JBC.M501376200

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29

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280

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Stefan N Constantinescu

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2005-05-16T00:00:00Z

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15899890

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