The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.
about
Pro-protein convertases control the maturation and processing of the iron-regulatory protein, RGMc/hemojuvelinSIX2 and BMP4 mutations associate with anomalous kidney developmentFurin at the cutting edge: from protein traffic to embryogenesis and diseaseLatent TGF-β structure and activationTargeting of bone morphogenetic protein growth factor complexes to fibrillinStructure of bone morphogenetic protein 9 procomplexDesigner TGFβ superfamily ligands with diversified functionalityBone morphogenetic protein-3b (BMP-3b) is expressed in adipocytes and inhibits adipogenesis as a unique complexRapid differential transport of Nodal and Lefty on sulfated proteoglycan-rich extracellular matrix regulates left-right asymmetry in XenopusExploring the effects of gene dosage on mandible shape in mice as a model for studying the genetic basis of natural variationAnalysis of Thisbe and Pyramus functional domains reveals evidence for cleavage of Drosophila FGFsA bone morphogenetic protein homologue in the parasitic flatworm, Schistosoma mansoni.Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in miceEvaluation of germline BMP4 mutation as a cause of colorectal cancer.Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations.Sortilin associates with transforming growth factor-beta family proteins to enhance lysosome-mediated degradation.The prodomain of BMP4 is necessary and sufficient to generate stable BMP4/7 heterodimers with enhanced bioactivity in vivoLoss of endothelial furin leads to cardiac malformation and early postnatal death.Opposite roles of furin and PC5A in N-cadherin processing.In vivo functions of the proprotein convertase PC5/6 during mouse development: Gdf11 is a likely substrate.Mechanical Forces Reshape Differentiation Cues That Guide Cardiomyogenesis.Effects of imposed defocus of opposite sign on temporal gene expression patterns of BMP4 and BMP7 in chick RPEA large bioactive BMP ligand with distinct signaling properties is produced by alternative proconvertase processing.Functional evaluation of a novel tooth agenesis-associated bone morphogenetic protein 4 prodomain mutationThe Drosophila DPP signal is produced by cleavage of its proprotein at evolutionary diversified furin-recognition sites.Unveiling the bmp13 enigma: redundant morphogen or crucial regulator?Site-specific cleavage of BMP4 by furin, PC6, and PC7.Cleavages within the prodomain direct intracellular trafficking and degradation of mature bone morphogenetic protein-4.Agonists and Antagonists of TGF-β Family Ligands.Structural Biology and Evolution of the TGF-β FamilyParallel Activin and BMP signaling coordinates R7/R8 photoreceptor subtype pairing in the stochastic Drosophila retina.Different requirements for proteolytic processing of bone morphogenetic protein 5/6/7/8 ligands in Drosophila melanogasterRegulation of Dpp activity by tissue-specific cleavage of an upstream site within the prodomain.Cathepsin H indirectly regulates morphogenetic protein-4 (BMP-4) in various human cell lines.Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.Alternative cleavage of the bone morphogenetic protein (BMP), Gbb, produces ligands with distinct developmental functions and receptor preferences.
P2860
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P2860
The activity and signaling range of mature BMP-4 is regulated by sequential cleavage at two sites within the prodomain of the precursor.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
The activity and signaling ran ...... he prodomain of the precursor.
@en
type
label
The activity and signaling ran ...... he prodomain of the precursor.
@en
prefLabel
The activity and signaling ran ...... he prodomain of the precursor.
@en
P2093
P2860
P356
P1433
P1476
The activity and signaling ran ...... he prodomain of the precursor.
@en
P2093
J L Christian
R Hackenmiller
T Nakayama
P2860
P304
P356
10.1101/GAD.940001
P577
2001-11-01T00:00:00Z