Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.
about
The amazing osteocyteImpact of mechanical stretch on the cell behaviors of bone and surrounding tissuesIn vitro and in vivo approaches to study osteocyte biologyApoptotic osteocytes and the control of targeted bone resorptionConnexin 43 hemichannels and intracellular signaling in bone cellsPreosteocytes/osteocytes have the potential to dedifferentiate becoming a source of osteoblastsEnhancement of osteogenic differentiation and proliferation in human mesenchymal stem cells by a modified low intensity ultrasound stimulation under simulated microgravity.Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signalingMechanical loading in osteocytes induces formation of a Src/Pyk2/MBD2 complex that suppresses anabolic gene expressionEvidence for pleiotropic factors in genetics of the musculoskeletal systemOsteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher DiseaseDynamic acoustic radiation force retains bone structural and mechanical integrity in a functional disuse osteopenia modelOptimal intensity shock wave promotes the adhesion and migration of rat osteoblasts via integrin β1-mediated expression of phosphorylated focal adhesion kinase.Oscillatory flow-induced proliferation of osteoblast-like cells is mediated by alphavbeta3 and beta1 integrins through synergistic interactions of focal adhesion kinase and Shc with phosphatidylinositol 3-kinase and the Akt/mTOR/p70S6K pathway.Mitogen-activated protein kinase phosphatase 1/dual specificity phosphatase 1 mediates glucocorticoid inhibition of osteoblast proliferationWhat old means to bone.Novel actions of bisphosphonates in bone: preservation of osteoblast and osteocyte viability.Osteocyte biology and space flight.Integrin αv in the mechanical response of osteoblast lineage cells.Role of calcitonin gene-related peptide in functional adaptation of the skeleton.Cyclic GMP and protein kinase G control a Src-containing mechanosome in osteoblasts.Adipose-derived stem cells in functional bone tissue engineering: lessons from bone mechanobiology.Estrogen augments shear stress-induced signaling and gene expression in osteoblast-like cells via estrogen receptor-mediated expression of beta1-integrin.Cx43 and mechanotransduction in bone.Ovariectomy enhances mechanical load-induced solute transport around osteocytes in rat cancellous bone.Mechanical stimulation of human tendon stem/progenitor cells results in upregulation of matrix proteins, integrins and MMPs, and activation of p38 and ERK1/2 kinases.Roles of gap junctions and hemichannels in bone cell functions and in signal transmission of mechanical stress.Cell autonomous requirement of connexin 43 for osteocyte survival: consequences for endocortical resorption and periosteal bone formation.Mechanosensation and Transduction in Osteocytes.Loading-related regulation of transcription factor EGR2/Krox-20 in bone cells is ERK1/2 protein-mediated and prostaglandin, Wnt signaling pathway-, and insulin-like growth factor-I axis-dependentInhibition of osteocyte apoptosis prevents the increase in osteocytic receptor activator of nuclear factor κB ligand (RANKL) but does not stop bone resorption or the loss of bone induced by unloading.Mechanobiology of the skeleton.Alterations in the osteocyte lacunar-canalicular microenvironment due to estrogen deficiency.Effects of cyclic hydraulic pressure on osteocytes.Molecular pathways mediating mechanical signaling in bone.Quantitative histologic evidence of amifostine-induced cytoprotection in an irradiated murine model of mandibular distraction osteogenesis.Beyond gap junctions: Connexin43 and bone cell signalingFor whom the bell tolls: distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases.Crosstalk between caveolin-1/extracellular signal-regulated kinase (ERK) and β-catenin survival pathways in osteocyte mechanotransductionOsteocyte apoptosis
P2860
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P2860
Mechanical stimulation prevents osteocyte apoptosis: requirement of integrins, Src kinases, and ERKs.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Mechanical stimulation prevent ...... egrins, Src kinases, and ERKs.
@en
type
label
Mechanical stimulation prevent ...... egrins, Src kinases, and ERKs.
@en
prefLabel
Mechanical stimulation prevent ...... egrins, Src kinases, and ERKs.
@en
P2093
P2860
P1476
Mechanical stimulation prevent ...... egrins, Src kinases, and ERKs.
@en
P2093
Aguirre JI
Manolagas SC
Parfitt AM
Plotkin LI
P2860
P304
P356
10.1152/AJPCELL.00278.2004
P577
2005-05-04T00:00:00Z