Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.
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Histone deacetylase 3 localizes to the mitotic spindle and is required for kinetochore-microtubule attachment.Histone modifications and nuclear architecture: a reviewHistone deacetylase inhibitors: Potential in cancer therapyA novel histone deacetylase pathway regulates mitosis by modulating Aurora B kinase activity.Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouseSirt2 functions in spindle organization and chromosome alignment in mouse oocyte meiosisRomidepsin in peripheral and cutaneous T-cell lymphoma: mechanistic implications from clinical and correlative dataRomidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors.Histone deacetylase inhibitors: a chemical genetics approach to understanding cellular functions.Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cellsThe clinical development of histone deacetylase inhibitors as targeted anticancer drugs.New histone deacetylase inhibitors improve cisplatin antitumor properties against thoracic cancer cells.A central role for TRPS1 in the control of cell cycle and cancer development.A new assay for measuring chromosome instability (CIN) and identification of drugs that elevate CIN in cancer cellsNudC deacetylation regulates mitotic progression.Histone modifications at the ABCG2 promoter following treatment with histone deacetylase inhibitor mirror those in multidrug-resistant cells.RbAp48 is essential for viability of vertebrate cells and plays a role in chromosome stability.Histone deacetylase inhibitors: clinical implications for hematological malignancies.A New Histone Deacetylase Inhibitor, MHY219, Inhibits the Migration of Human Prostate Cancer Cells via HDAC1.Aurora B is regulated by acetylation/deacetylation during mitosis in prostate cancer cells.Histone deacetylase inhibitor-mediated cell death is distinct from its global effect on chromatin.How to build a centromere: from centromeric and pericentromeric chromatin to kinetochore assembly.Effects of Anticancer Drugs on Chromosome Instability and New Clinical Implications for Tumor-Suppressing Therapies.Reactivation of DNA viruses in association with histone deacetylase inhibitor therapy: a case series report.Inhibition of histone deacetylases induces formation of multipolar spindles and subsequent p53-dependent apoptosis in nasopharyngeal carcinoma cells.Histone deacetylase inhibitors for the treatment of myelodysplastic syndrome and acute myeloid leukemia.Potential of histone deacetylase inhibitors for bladder cancer treatment.Histone deacetylase inhibitors in the treatment of cancer: overview and perspectives.Stressing mitosis to death.Belinostat and vincristine demonstrate mutually synergistic cytotoxicity associated with mitotic arrest and inhibition of polyploidy in a preclinical model of aggressive diffuse large B cell lymphoma.Microtubule dynamics decoded by the epigenetic state of centromeric chromatin.A focus on the preclinical development and clinical status of the histone deacetylase inhibitor, romidepsin (depsipeptide, Istodax(®)).Aurora B-dependent regulation of class IIa histone deacetylases by mitotic nuclear localization signal phosphorylation.Inhibitors of histone deacetylases induce tumor-selective cytotoxicity through modulating Aurora-A kinase.The multi zinc-finger protein Trps1 acts as a regulator of histone deacetylation during mitosis.Acetylation of RNA processing proteins and cell cycle proteins in mitosis.Molecular and cellular pathways associated with chromosome 1p deletions during colon carcinogenesis.HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.Histone deacetylase 3 is required for centromeric H3K4 deacetylation and sister chromatid cohesion.Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.
P2860
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P2860
Inhibitors of histone deacetylases alter kinetochore assembly by disrupting pericentromeric heterochromatin.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Inhibitors of histone deacetyl ...... ricentromeric heterochromatin.
@en
type
label
Inhibitors of histone deacetyl ...... ricentromeric heterochromatin.
@en
prefLabel
Inhibitors of histone deacetyl ...... ricentromeric heterochromatin.
@en
P2093
P356
P1433
P1476
Inhibitors of histone deacetyl ...... ericentromeric heterochromatin
@en
P2093
April R Robbins
Dan L Sackett
Kinya Yoda
Susan E Bates
P304
P356
10.4161/CC.4.5.1690
P577
2005-05-28T00:00:00Z