HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells. - Wikidata - wikimedia - TriplyDB

HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

http://www.wikidata.org/entity/Q42952064

about

Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging Molecular dissection of formation of senescence-associated heterochromatin foci Human UBN1 is an ortholog of yeast Hpc2p and has an essential role in the HIRA/ASF1a chromatin-remodeling pathway in senescent cells.The essential role of Drosophila HIRA for de novo assembly of paternal chromatin at fertilization Histone variants: emerging players in cancer biology.A single mutation results in diploid gamete formation and parthenogenesis in a Drosophila yemanuclein-alpha meiosis I defective mutant.HP1-mediated formation of alternative lengthening of telomeres-associated PML bodies requires HIRA but not ASF1a.Azacytidine induces cell cycle arrest and suppression of neuroendocrine markers in carcinoids.Ring-like distribution of constitutive heterochromatin in bovine senescent cells.HP1γ expression is elevated in prostate cancer and is superior to Gleason score as a predictor of biochemical recurrence after radical prostatectomy.Enhancer of zeste homolog 2 promotes the proliferation and invasion of epithelial ovarian cancer cells.Chromatin dynamics during DNA repair revealed by pair correlation analysis of molecular flow in the nucleus.Human CABIN1 is a functional member of the human HIRA/UBN1/ASF1a histone H3.3 chaperone complex.Histone variant H3.3 stimulates HSP70 transcription through cooperation with HP1γ Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex Identification of cellular proteins that maintain retroviral epigenetic silencing: evidence for an antiviral response.Detection of senescence-associated heterochromatin foci (SAHF).BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss HP1-beta is required for development of the cerebral neocortex and neuromuscular junctions The epigenetic origin of aneuploidy.The emerging role of HP1 in the DNA damage response.Identification of ribonucleotide reductase M2 as a potential target for pro-senescence therapy in epithelial ovarian cancer Dynamics of histone H3.3 deposition in proliferating and senescent cells reveals a DAXX-dependent targeting to PML-NBs important for pericentromeric heterochromatin organization.The changing faces of HP1: From heterochromatin formation and gene silencing to euchromatic gene expression: HP1 acts as a positive regulator of transcription.Heterochromatin and the DNA damage response: the need to relax.Chromatin maintenance and dynamics in senescence: a spotlight on SAHF formation and the epigenome of senescent cells.MTA family of proteins in DNA damage response: mechanistic insights and potential applications.A Molecular Prospective for HIRA Complex Assembly and H3.3-Specific Histone Chaperone Function.Suppression of nucleotide metabolism underlies the establishment and maintenance of oncogene-induced senescence.The centrosomal protein TACC3 controls paclitaxel sensitivity by modulating a premature senescence program.Definition of pRB- and p53-dependent and -independent steps in HIRA/ASF1a-mediated formation of senescence-associated heterochromatin foci.Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells New partners for HP1 in transcriptional gene silencing.Differential distribution of HP1 proteins after trichostatin a treatment influences chromosomal stability in HCT116 and WI-38 cells.Epigenetics in Turner syndrome.Promyelocytic leukemia (PML) nuclear bodies (NBs) induce latent/quiescent HSV-1 genomes chromatinization through a PML NB/Histone H3.3/H3.3 Chaperone Axis

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HP1 proteins are essential for a dynamic nuclear response that rescues the function of perturbed heterochromatin in primary human cells.

http://www.wikidata.org/entity/Q42952064

description

2006 nî lūn-bûn

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name

HP1 proteins are essential for ...... omatin in primary human cells.

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HP1 proteins are essential for ...... omatin in primary human cells.

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HP1 proteins are essential for ...... omatin in primary human cells.

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HP1 proteins are essential for ...... omatin in primary human cells.

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HP1 proteins are essential for ...... omatin in primary human cells.

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P1433

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Molecular and Cellular Biology

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HP1 proteins are essential for ...... romatin in primary human cells

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John Pehrson

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Peter D Adams

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Rugang Zhang

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Wei Chen

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P2860

hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase

Expression patterns and post-translational modifications associated with mammalian histone H3 variants

A complex with chromatin modifiers that occupies E2F- and Myc-responsive genes in G0 cells

Histone H3.1 and H3.3 complexes mediate nucleosome assembly pathways dependent or independent of DNA synthesis

A conserved Mis12 centromere complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint-1

HIRA, the human homologue of yeast Hir1p and Hir2p, is a novel cyclin-cdk2 substrate whose expression blocks S-phase progression

Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

Histone H3.3 variant dynamics in the germline of Caenorhabditis elegans

Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins

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949-962

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10.1128/MCB.01639-06

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3

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27

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Michael F Bonner

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17101789

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1800672

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