Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

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http://www.wikidata.org/entity/Q40433595

Q40433595

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The Yersinia enterocolitica effector YopP inhibits host cell signalling by inactivating the protein kinase TAK1 in the IL-1 signalling pathway Ubiquitin signaling in immune responses RIPK3 contributes to TNFR1-mediated RIPK1 kinase-dependent apoptosis in conditions of cIAP1/2 depletion or TAK1 kinase inhibition Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1.Regulation of TAK1/TAB1-mediated IL-1β signaling by cytoplasmic PPARβ/δ.Transforming growth factor-β and the hallmarks of cancer.Phosphorylation of NF-kappaB p65 at Ser468 controls its COMMD1-dependent ubiquitination and target gene-specific proteasomal elimination An essential role for TAK1 in the contact hypersensitivity response Modulation of pancreatic cancer chemoresistance by inhibition of TAK1 c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies RNAi screening identifies TAK1 as a potential target for the enhanced efficacy of topoisomerase inhibitors.Enforced expression of Lin28b leads to impaired T-cell development, release of inflammatory cytokines, and peripheral T-cell lymphoma Protection from cerebral ischemia by inhibition of TGFβ-activated kinase Role of transforming growth factor-beta in cancer progression.c-Jun controls histone modifications, NF-kappaB recruitment, and RNA polymerase II function to activate the ccl2 gene.Altered TAB1:I kappaB kinase interaction promotes transforming growth factor beta-mediated nuclear factor-kappaB activation during breast cancer progression.Increased apoptosis and browning of TAK1-deficient adipocytes protects against obesity Transforming growth factor-beta (TGF-beta1) activates TAK1 via TAB1-mediated autophosphorylation, independent of TGF-beta receptor kinase activity in mesangial cells.Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.Emerging pathways and future targets for the molecular therapy of pancreatic cancer.NF-κB as a target for pancreatic cancer therapy.MAPK p38 and JNK have opposing activities on TRAIL-induced apoptosis activation in NSCLC H460 cells that involves RIP1 and caspase-8 and is mediated by Mcl-1.Inhibitors of TLR-4, NF-κB, and SAPK/JNK signaling reduce the toxic effect of lipopolysaccharide on RAW 264.7 cells.Differential expression of immunoregulatory genes in monocytes in response to Porphyromonas gingivalis and Escherichia coli lipopolysaccharide.Transcriptional regulation of EGR-1 by the interleukin-1-JNK-MKK7-c-Jun pathway.Suppressor of cytokine signaling 3 plays an important role in porcine circovirus type 2 subclinical infection by downregulating proinflammatory responses.Phosphorylation and polyubiquitination of transforming growth factor beta-activated kinase 1 are necessary for activation of NF-kappaB by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor.Regulation of the JNK pathway by TGF-beta activated kinase 1 in rheumatoid arthritis synoviocytes.Inflammatory cytokines stimulate the chemokines CCL2/MCP-1 and CCL7/MCP-3 through NFkB and MAPK dependent pathways in rat astrocytes [corrected].TAK1 activates NFkB by phosphorylation and activation of IKKs complex JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 activated TAK1 mediates p38 MAPK activation TAK1-mediated transcriptional activation of CD28-responsive element and AP-1-binding site within the IL-2 promoter in Jurkat T cells.MAPK8 regulates chicken male germ cell differentiation through JNK signaling pathway.Activated TAK1 phosphorylates MKK4/MKK7 activated human TAK1 phosphorylates MKK3/MKK6 Increased plasma levels epithelial cell-derived neutrophil-activating peptide 78/CXCL5 in periodontitis patients undergoing supportive therapy.TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.

P2860

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P2860

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

Item

http://www.wikidata.org/entity/Q40433595

description

2005 nî lūn-bûn

@nan

2005年の論文

@ja

2005年学术文章

@wuu

2005年学术文章

@zh-cn

2005年学术文章

@zh-hans

2005年学术文章

@zh-my

2005年学术文章

@zh-sg

2005年學術文章

@yue

2005年學術文章

@zh

2005年學術文章

@zh-hant

name

Simultaneous blockade of NFkap ...... ctor [corrected] target genes.

@en

type

Item

label

Simultaneous blockade of NFkap ...... ctor [corrected] target genes.

@en

prefLabel

Simultaneous blockade of NFkap ...... ctor [corrected] target genes.

@en

P1476

Simultaneous blockade of NFkap ...... ctor [corrected] target genes.

@en

P2093

Anneke Dörrie

http://www.w3.org/2001/XMLSchema#string

Axel Thiefes

http://www.w3.org/2001/XMLSchema#string

Bruno Luckow

http://www.w3.org/2001/XMLSchema#string

Dagmar Wirth

http://www.w3.org/2001/XMLSchema#string

Elke Hoffmann

http://www.w3.org/2001/XMLSchema#string

Heike Schneider

http://www.w3.org/2001/XMLSchema#string

J Frederic Mushinski

http://www.w3.org/2001/XMLSchema#string

Klaus Resch

http://www.w3.org/2001/XMLSchema#string

Nadine Graue

http://www.w3.org/2001/XMLSchema#string

Oliver Dittrich-Breiholz

http://www.w3.org/2001/XMLSchema#string

P2860

The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway

Differential transcriptional regulation of the monocyte-chemoattractant protein-1 (MCP-1) gene in tumorigenic and non-tumorigenic HPV 18 positive cells: the role of the chromatin structure and AP-1 composition

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

IAP suppression of apoptosis involves distinct mechanisms: the TAK1/JNK1 signaling cascade and caspase inhibition.

Tumor necrosis factor-alpha-induced IKK phosphorylation of NF-kappaB p65 on serine 536 is mediated through the TRAF2, TRAF5, and TAK1 signaling pathway

Constitutive and interleukin-1-inducible phosphorylation of p65 NF-{kappa}B at serine 536 is mediated by multiple protein kinases including I{kappa}B kinase (IKK)-{alpha}, IKK{beta}, IKK{epsilon}, TRAF family member-associated (TANK)-binding kinase

TAB3, a new binding partner of the protein kinase TAK1

Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6

Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway

Computational prediction of transcription-factor binding site locations

P304

27728-27741

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M411657200

http://www.w3.org/2001/XMLSchema#string

P407

English

P433

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P50

Michael Kracht

P577

2005-04-18T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15837794

http://www.w3.org/2001/XMLSchema#string

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

about

P2860

P2860

Simultaneous blockade of NFkappaB, JNK, and p38 MAPK by a kinase-inactive mutant of the protein kinase TAK1 sensitizes cells to apoptosis and affects a distinct spectrum of tumor necrosis factor [corrected] target genes.

description

name

type

label

prefLabel

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698

P356

P1433

P1476

P2093

P2860

P304

P31

P356

P407

P433

P478

P50

P577

P698