Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases. - Wikidata - wikimedia - TriplyDB

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

http://www.wikidata.org/entity/Q40435143

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Protein-tyrosine phosphatase 1B modulates early endosome fusion and trafficking of Met and epidermal growth factor receptors Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase Association of the protein-tyrosine phosphatase DEP-1 with its substrate FLT3 visualized by in situ proximity ligation assay Protein tyrosine phosphatase 1B negatively regulates macrophage development through CSF-1 signaling.Recent developments in receptor tyrosine kinases targeted anticancer therapy Internalization and down-regulation of the ALK receptor in neuroblastoma cell lines upon monoclonal antibodies treatment Common and specific effects of TIE2 mutations causing venous malformations Intracellular signaling prevents effective blockade of oncogenic gp130 mutants by neutralizing antibodies.The localization of FGFR3 mutations causing thanatophoric dysplasia type I differentially affects phosphorylation, processing and ubiquitylation of the receptor.Pim-1 kinase phosphorylates and stabilizes 130 kDa FLT3 and promotes aberrant STAT5 signaling in acute myeloid leukemia with FLT3 internal tandem duplication Activating FLT3 mutants show distinct gain-of-function phenotypes in vitro and a characteristic signaling pathway profile associated with prognosis in acute myeloid leukemia.Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia.A point mutation in the extracellular domain of KIT promotes tumorigenesis of mast cells via ligand-independent auto-dimerization Neoplasia driven by mutant c-KIT is mediated by intracellular, not plasma membrane, receptor signaling.Fluvastatin inhibits FLT3 glycosylation in human and murine cells and prolongs survival of mice with FLT3/ITD leukemia.Emerging Flt3 kinase inhibitors in the treatment of leukaemia.Hiding inside? Intracellular expression of non-glycosylated c-kit protein in cardiac progenitor cells Protein tyrosine phosphatases: regulatory mechanisms.Somatic mutations in angiopoietin receptor gene TEK cause solitary and multiple sporadic venous malformations Protein tyrosine phosphatases PTP-1B and TC-PTP play nonredundant roles in macrophage development and IFN-gamma signaling.Effects of membrane trafficking on signaling by receptor tyrosine kinases.Differential regulation of FGFR3 by PTPN1 and PTPN2.c-Cbl and Cbl-b ligases mediate 17-allylaminodemethoxygeldanamycin-induced degradation of autophosphorylated Flt3 kinase with internal tandem duplication through the ubiquitin proteasome pathway.Constitutive activation of oncogenic PDGFRα-mutant proteins occurring in GIST patients induces receptor mislocalisation and alters PDGFRα signalling characteristics.KIT-D816V oncogenic activity is controlled by the juxtamembrane docking site Y568-Y570.High CD133 expression levels in gastrointestinal stromal tumors.Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling.The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking.Ubiquitin conjugase UBCH8 targets active FMS-like tyrosine kinase 3 for proteasomal degradation.Sprouty 2 disturbs FGFR3 degradation in thanatophoric dysplasia type II: a severe form of human achondroplasia.RUNX1 cooperates with FLT3-ITD to induce leukemia.Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants.Synergistic killing of FLT3ITD-positive AML cells by combined inhibition of tyrosine-kinase activity and N-glycosylation.Expression of protein-tyrosine phosphatases in Acute Myeloid Leukemia cells: FLT3 ITD sustains high levels of DUSP6 expression.UBC9-dependent association between calnexin and protein tyrosine phosphatase 1B (PTP1B) at the endoplasmic reticulum A genome-wide RNAi screen identifies proteins modulating aberrant FLT3-ITD signaling.SHIP-1 inhibits CD95/APO-1/Fas-induced apoptosis in primary T lymphocytes and T leukemic cells by promoting CD95 glycosylation independently of its phosphatase activity.Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3.Molecular and cellular effects of oncogene cooperation in a genetically accurate AML mouse model.Role of SHP2 for FLT3-dependent proliferation and transformation in 32D cells.

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Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

http://www.wikidata.org/entity/Q40435143

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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name

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

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type

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Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

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prefLabel

Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

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MCB.25.9.3690-3703.2005

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Molecular and Cellular Biology

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Tyrosine phosphorylation regulates maturation of receptor tyrosine kinases.

@en

P2093

Annette Böhmer

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Boyka Markova

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Chunaram Choudhary

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Dirk-E Schmidt-Arras

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Frank-D Böhmer

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Hubert Serve

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P2860

Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

Identification of two juxtamembrane autophosphorylation sites in the PDGF beta-receptor; involvement in the interaction with Src family tyrosine kinases

COOH-terminal sequence motifs target the T cell protein tyrosine phosphatase to the ER and nucleus

Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma

A system for stable expression of short interfering RNAs in mammalian cells

The protein-tyrosine phosphatase SHP-1 binds to and dephosphorylates p120 catenin

A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo

Lyn associates with the juxtamembrane region of c-Kit and is activated by stem cell factor in hematopoietic cell lines and normal progenitor cells

Roles of N-linked glycans in the endoplasmic reticulum

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3690-3703

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10.1128/MCB.25.9.3690-3703.2005

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9

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25

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15831474

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phosphorylation

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1084288

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