Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
about
pVHL acts as an adaptor to promote the inhibitory phosphorylation of the NF-kappaB agonist Card9 by CK2VHL inactivation induces HEF1 and Aurora kinase AThe von Hippel-Lindau tumour suppressor interacts with microtubules through kinesin-2A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy.Priming-dependent phosphorylation and regulation of the tumor suppressor pVHL by glycogen synthase kinase 3.Ubiquitin pathway in VHL cancer syndrome.CK2 in Cancer: Cellular and Biochemical Mechanisms and Potential Therapeutic Target.Nek1 phosphorylates Von Hippel-Lindau tumor suppressor to promote its proteasomal degradation and ciliary destabilization.Elevated cell invasion is induced by hypoxia in a human pituitary adenoma cell line.Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins.Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.Hypoxia and antitumor CD8+ T cells: An incompatible alliance?Nuclear E-cadherin and VHL immunoreactivity are prognostic indicators of clear-cell renal cell carcinoma.Adding structural information to the von Hippel-Lindau (VHL) tumor suppressor interaction network.Quantitative proteomics to study a small molecule targeting the loss of von Hippel-Lindau in renal cell carcinomas.Molecular and physiological roles of the adaptor protein CARD9 in immunity.Under-expression of CK2β subunit in ccRCC represents a complementary biomarker of p-STAT3 Ser727 that correlates with patient survival.Novel Homozygous Mutation of the Internal Translation Initiation Start Site of VHL is Exclusively Associated with Erythrocytosis: Indications for Distinct Functional Roles of von Hippel-Lindau Tumor Suppressor Isoforms.Metastatic Renal Cell Cancer-Systemic Therapy.RSUME inhibits VHL and regulates its tumor suppressor function.
P2860
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P2860
Tumor suppression by the von Hippel-Lindau protein requires phosphorylation of the acidic domain.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Tumor suppression by the von H ...... rylation of the acidic domain.
@en
type
label
Tumor suppression by the von H ...... rylation of the acidic domain.
@en
prefLabel
Tumor suppression by the von H ...... rylation of the acidic domain.
@en
P2093
P2860
P356
P1476
Tumor suppression by the von H ...... rylation of the acidic domain.
@en
P2093
Cristel M Snijckers
Emile E Voest
Martijn P Lolkema
Michael Ohh
Michelle L Gervais
Rachel H Giles
Richard P Hill
P2860
P304
22205-22211
P356
10.1074/JBC.M503220200
P407
P577
2005-04-11T00:00:00Z