Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dow
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Decreased TCF7L2 protein levels in type 2 diabetes mellitus correlate with downregulation of GIP- and GLP-1 receptors and impaired beta-cell functionIdentification of a WD40 repeat-containing isoform of PHIP as a novel regulator of beta-cell growth and survivalRecent advances in understanding the anti-diabetic actions of dietary flavonoidsMolecular Mechanisms of the Anti-Obesity and Anti-Diabetic Properties of FlavonoidsPancreatic regulation of glucose homeostasisNew perspectives on exploitation of incretin peptides for the treatment of diabetes and related disordersPotential roles of GPR120 and its agonists in the management of diabetesKinase Signaling in Apoptosis Induced by Saturated Fatty Acids in Pancreatic β-CellsThe antiapoptotic function of miR-96 in prostate cancer by inhibition of FOXO1Glucose-dependent insulinotropic polypeptide-mediated up-regulation of beta-cell antiapoptotic Bcl-2 gene expression is coordinated by cyclic AMP (cAMP) response element binding protein (CREB) and cAMP-responsive CREB coactivator 2The entero-insular axis: implications for human metabolism.A GIP receptor agonist exhibits beta-cell anti-apoptotic actions in rat models of diabetes resulting in improved beta-cell function and glycemic control.Pharmacological characterization of human incretin receptor missense variantsTranscriptional analysis of apoptotic cerebellar granule neurons following rescue by gastric inhibitory polypeptideGIP and GLP-1, the two incretin hormones: Similarities and differencesGlucose-dependent insulinotropic polypeptide signaling in pancreatic β-cells and adipocytesSlow and steady is the key to beta-cell replication.The incretin system and cardiometabolic diseaseSitagliptin (MK0431) inhibition of dipeptidyl peptidase IV decreases nonobese diabetic mouse CD4+ T-cell migration through incretin-dependent and -independent pathways.Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice.Glucose-dependent insulinotropic polypeptide stimulates the proliferation of colorectal cancer cells.The pseudokinase tribbles homolog 3 interacts with ATF4 to negatively regulate insulin exocytosis in human and mouse beta cells.Differential responses of the incretin hormones GIP and GLP-1 to increasing doses of dietary carbohydrate but not dietary protein in lean rats.Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway.GIP increases human adipocyte LPL expression through CREB and TORC2-mediated trans-activation of the LPL gene.The role of incretins in glucose homeostasis and diabetes treatment.Pleiotropic effects of GIP on islet function involve osteopontin.The role of gut hormones in glucose homeostasisGlucolipotoxicity impairs ceramide flow from the endoplasmic reticulum to the Golgi apparatus in INS-1 β-cellsGlucagon-like peptide 1 inhibits the sirtuin deacetylase SirT1 to stimulate pancreatic β-cell mass expansion.Akt and PTEN: beta-cell mass and pancreas plasticity.Effects of High Glucose Levels and Glycated Serum on GIP Responsiveness in the Pancreatic Beta Cell Line HIT-T15.Liraglutide protects pancreatic β-cells against free fatty acids in vitro and affects glucolipid metabolism in apolipoprotein E-/- mice by activating autophagy.Chronic high-fat feeding increases GIP and GLP-1 secretion without altering body weightGlucose-dependent insulinotropic polypeptide enhances adipocyte development and glucose uptake in part through Akt activation.Review article: the emerging interplay among the gastrointestinal tract, bile acids and incretins in the pathogenesis of diabetes and non-alcoholic fatty liver disease.Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction.Cocaine- and amphetamine-regulated transcript (CART) protects beta cells against glucotoxicity and increases cell proliferation.The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.Crosstalk between the AMP-activated kinase and insulin signaling pathways rescues murine blastocyst cells from insulin resistance.
P2860
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P2860
Glucose-dependent insulinotropic polypeptide (GIP) stimulation of pancreatic beta-cell survival is dependent upon phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB) signaling, inactivation of the forkhead transcription factor Foxo1, and dow
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Glucose-dependent insulinotrop ...... cription factor Foxo1, and dow
@en
type
label
Glucose-dependent insulinotrop ...... cription factor Foxo1, and dow
@en
prefLabel
Glucose-dependent insulinotrop ...... cription factor Foxo1, and dow
@en
P2093
P2860
P356
P1476
Glucose-dependent insulinotrop ...... n-regulation of bax expression
@en
P2093
Christopher H S McIntosh
Cuilan Nian
Kyle Winter
Makoto Tsuneoka
Su-Jin Kim
P2860
P304
22297-22307
P356
10.1074/JBC.M500540200
P407
P50
P577
2005-04-06T00:00:00Z