Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
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Is adiposopathy (sick fat) an endocrine disease?Linking obesity with type 2 diabetes: the role of T-betSphingolipid signaling in metabolic disordersOn ceramides, other sphingolipids and impaired glucose homeostasisDefect of insulin signal in peripheral tissues: Important role of ceramideBiomarkers in nonalcoholic fatty liver diseaseRole of ceramide in diabetes mellitus: evidence and mechanisms.PGC-1alpha regulation by exercise training and its influences on muscle function and insulin sensitivity.Ceramide-mediated insulin resistance and impairment of cognitive-motor functionsInsulin resistance is associated with higher intramyocellular triglycerides in type I but not type II myocytes concomitant with higher ceramide content.Cloning and characterization of a wheat neutral ceramidase gene Ta-CDase.Screening native botanicals for bioactivity: an interdisciplinary approach.Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humansHigh fat diet induced hepatic steatosis and insulin resistance: Role of dysregulated ceramide metabolism.Saturated- and n-6 polyunsaturated-fat diets each induce ceramide accumulation in mouse skeletal muscle: reversal and improvement of glucose tolerance by lipid metabolism inhibitors.Effect of metformin on metabolic improvement and gut microbiotaMetabolic derangements mediate cognitive impairment and Alzheimer's disease: role of peripheral insulin-resistance diseasesCeramides and glucosylceramides are independent antagonists of insulin signalingCharacterization of genes involved in ceramide metabolism in the Pacific oyster (Crassostrea gigas).Adiposopathy: how do diet, exercise and weight loss drug therapies improve metabolic disease in overweight patients?An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes.Differential regulation of dihydroceramide desaturase by palmitate versus monounsaturated fatty acids: implications for insulin resistanceGlucose and palmitate uncouple AMPK from autophagy in human aortic endothelial cellsPerilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistanceCeramides as modulators of cellular and whole-body metabolismFat-induced membrane cholesterol accrual provokes cortical filamentous actin destabilisation and glucose transport dysfunction in skeletal muscleModulation of sphingolipid metabolism with calorie restriction enhances insulin action in skeletal muscle.Protective role of oleic acid against cardiovascular insulin resistance and in the early and late cellular atherosclerotic process.MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial functionStinging Nettle (Urtica dioica L.) Attenuates FFA Induced Ceramide Accumulation in 3T3-L1 Adipocytes in an Adiponectin Dependent Manner.Cross-talk between branched-chain amino acids and hepatic mitochondria is compromised in nonalcoholic fatty liver diseaseMechanisms of ceramide-mediated neurodegeneration.Brain metabolic dysfunction at the core of Alzheimer's disease.Triangulated mal-signaling in Alzheimer's disease: roles of neurotoxic ceramides, ER stress, and insulin resistance reviewedFenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesisAccelerated renal disease is associated with the development of metabolic syndrome in a glucolipotoxic mouse model.Rapamycin has a biphasic effect on insulin sensitivity in C2C12 myotubes due to sequential disruption of mTORC1 and mTORC2.Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults.Cardiac lipotoxicity: molecular pathways and therapeutic implications.
P2860
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P2860
Acid ceramidase overexpression prevents the inhibitory effects of saturated fatty acids on insulin signaling.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Acid ceramidase overexpression ...... ty acids on insulin signaling.
@en
type
label
Acid ceramidase overexpression ...... ty acids on insulin signaling.
@en
prefLabel
Acid ceramidase overexpression ...... ty acids on insulin signaling.
@en
P2093
P2860
P921
P356
P1476
Acid ceramidase overexpression ...... ty acids on insulin signaling.
@en
P2093
Jose Antonio Chavez
Konrad Sandhoff
Scott A Summers
William L Holland
P2860
P304
20148-20153
P356
10.1074/JBC.M412769200
P407
P577
2005-03-17T00:00:00Z