Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins.
about
Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"Fc-fusion proteins and FcRn: structural insights for longer-lasting and more effective therapeuticsDangerous liaisons: how the immune system deals with factor VIIIAnimal models of hemophiliaRecombinant factor VIII Fc (rFVIIIFc) fusion protein reduces immunogenicity and induces tolerance in hemophilia A miceSuppression of FVIII inhibitor formation in hemophilic mice by delivery of transgene modified apoptotic fibroblasts.Multimerization of peptide mimotopes for blocking of factor VIII neutralizing antibodies.Immune tolerance induction to factor IX through B cell gene transfer: TLR9 signaling delineates between tolerogenic and immunogenic B cells.B-cell delivered gene therapy for tolerance induction: role of autoantigen-specific B cells.Suppression of inhibitor formation against FVIII in a murine model of hemophilia A by oral delivery of antigens bioencapsulated in plant cellsRegulatory T cell epitopes (Tregitopes) in IgG induce tolerance in vivo and lack immunogenicity per se.Inhibitors - cellular aspects and novel approaches for tolerance.Eradication of neutralizing antibodies to factor VIII in canine hemophilia A after liver gene therapy.Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A mice.Development of Gene Transfer for Induction of Antigen-specific Tolerance.B-Cell Gene Therapy for Tolerance Induction: Host but Not Donor B-Cell Derived IL-10 is Necessary for Tolerance.Design of the INHIBIT trial: preventing inhibitors by avoiding 'danger', prolonging half-life and promoting tolerance.B cells "transduced" with TAT-fusion proteins can induce tolerance and protect mice from diabetes and EAEProfile of efraloctocog alfa and its potential in the treatment of hemophilia A.Gene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation.Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo.Toll-like receptor 4-activated B cells out-compete Toll-like receptor 9-activated B cells to establish peripheral immunological tolerance.Lentiviral vectors displaying modified measles virus gp overcome pre-existing immunity in in vivo-like transduction of human T and B cells.FVIII-specific human chimeric antigen receptor T-regulatory cells suppress T- and B-cell responses to FVIII.Novel therapies for immune tolerance in haemophilia A.Mechanisms of action of immune tolerance induction against factor VIII in patients with congenital haemophilia A and factor VIII inhibitors.Tolerance to MHC class II disparate allografts through genetic modification of bone marrow.Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A miceB cells induce tolerance by presenting endogenous peptide-IgG on MHC class II molecules via an IFN-gamma-inducible lysosomal thiol reductase-dependent pathwayStaunch protections: the ethics of haemophilia gene transfer research.Antigen-specific tolerogenic and immunomodulatory strategies for the treatment of autoimmune arthritis.Inhibitor development.Induction of Hematopoietic Microchimerism by Gene-Modified BMT Elicits Antigen-Specific B and T Cell Unresponsiveness toward Gene Therapy ProductsA role for thrombin in the initiation of the immune response to therapeutic factor VIII.Role of regulatory T cells in tolerance to coagulation factors.Advances in the field of lentivector-based transduction of T and B lymphocytes for gene therapy.Immunomodulation for inhibitors in hemophilia A: the important role of Treg cellsProgress toward inducing immunologic tolerance to factor VIII.Prolonged activity of a recombinant factor VIII-Fc fusion protein in hemophilia A mice and dogs.New and Emerging Agents for the Treatment of Hemophilia: Focus on Extended Half-Life Recombinant Clotting Proteins.
P2860
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P2860
Induction of tolerance to factor VIII inhibitors by gene therapy with immunodominant A2 and C2 domains presented by B cells as Ig fusion proteins.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Induction of tolerance to fact ...... B cells as Ig fusion proteins.
@en
type
label
Induction of tolerance to fact ...... B cells as Ig fusion proteins.
@en
prefLabel
Induction of tolerance to fact ...... B cells as Ig fusion proteins.
@en
P2860
P1433
P1476
Induction of tolerance to fact ...... B cells as Ig fusion proteins.
@en
P2093
David W Scott
Tie Chi Lei
P2860
P304
P356
10.1182/BLOOD-2004-11-4274
P407
P577
2005-03-15T00:00:00Z