Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors. - Wikidata - wikimedia - TriplyDB

Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors.

Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors.

http://www.wikidata.org/entity/Q40465847

about

Genetic alterations in seborrheic keratoses.IQGAP1 and IQGAP3 Serve Individually Essential Roles in Normal Epidermal Homeostasis and Tumor Progression.Focal-adhesion-independent integrin-αv regulation of FAK and c-Myc is necessary for 3D skin formation and tumor invasion Fibroblast growth factor receptor 3 protein is overexpressed in oral and oropharyngeal squamous cell carcinoma.Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors.Computational identification of microRNAs associated to both epithelial to mesenchymal transition and NGAL/MMP-9 pathways in bladder cancer.Familial seborrhoeic keratosis associated with multiple "pure reticulated acanthomas" and infundibulocystic basal cell carcinomas.Kinase Activity of Fibroblast Growth Factor Receptor 3 Regulates Activity of the Papillomavirus E2 Protein.Eruptive Seborrheic Keratoses Restricted to Plaque/Patch-Stage Mycosis Fungoides.Evaluation of FGFR3 as a Therapeutic Target in Head and Neck Squamous Cell Carcinoma.[Genetic basis of seborrheic keratosis and epidermal nevi].

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P2860

Activating FGFR3 mutations cause mild hyperplasia in human skin, but are insufficient to drive benign or malignant skin tumors.

http://www.wikidata.org/entity/Q40465847

description

2014 nî lūn-bûn

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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2014年论文

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2014年论文

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Activating FGFR3 mutations cau ...... nign or malignant skin tumors.

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Activating FGFR3 mutations cau ...... nign or malignant skin tumors.

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Activating FGFR3 mutations cau ...... nign or malignant skin tumors.

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Andrew McNeal

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Elizabeth K Duperret

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Seung Ja Oh

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Stephen M Prouty

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P2860

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

Frequent translocation t(4;14)(p16.3;q32.3) in multiple myeloma is associated with increased expression and activating mutations of fibroblast growth factor receptor 3

Fibroblast growth factor receptor 3 mutations in epidermal nevi and associated low grade bladder tumors

Preclinical studies of fibroblast growth factor receptor 3 as a therapeutic target in multiple myeloma

Multiple oncogenic mutations and clonal relationship in spatially distinct benign human epidermal tumors

Mosaicism of activating FGFR3 mutations in human skin causes epidermal nevi.

UVA induces lesions resembling seborrheic keratoses in mice with keratinocyte-specific PTEN downregulation

The novel JAK inhibitor AZD1480 blocks STAT3 and FGFR3 signaling, resulting in suppression of human myeloma cell growth and survival.

Oncogenic PIK3CA mutations occur in epidermal nevi and seborrheic keratoses with a characteristic mutation pattern.

A positive FGFR3/FOXN1 feedback loop underlies benign skin keratosis versus squamous cell carcinoma formation in humans.

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10.4161/CC.28492

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10

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