Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef
about
Molecular design, functional characterization and structural basis of a protein inhibitor against the HIV-1 pathogenicity factor NefSAMHD1 restricts HIV-1 infection in resting CD4(+) T cells.Nef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142High natural permissivity of primary rabbit cells for HIV-1, with a virion infectivity defect in macrophages as the final replication barrier.HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcriptionPrimary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.Determinants in HIV-1 Nef for enhancement of virus replication and depletion of CD4+ T lymphocytes in human lymphoid tissue ex vivoPharmacovirological impact of an integrase inhibitor on human immunodeficiency virus type 1 cDNA species in vivoThe Antagonism of HIV-1 Nef to SERINC5 Particle Infectivity Restriction Involves the Counteraction of Virion-Associated Pools of the Restriction Factor.Controversies in the pathogenesis of HIV-associated renal diseases.Activation of p21-activated kinase 2 and its association with Nef are conserved in murine cells but are not sufficient to induce an AIDS-like disease in CD4C/HIV transgenic mice.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.β-TrCP is dispensable for Vpu's ability to overcome the CD317/Tetherin-imposed restriction to HIV-1 release.Endogenous CD317/Tetherin limits replication of HIV-1 and murine leukemia virus in rodent cells and is resistant to antagonists from primate viruses.Human immunodeficiency virus type 1 Nef protein modulates the lipid composition of virions and host cell membrane microdomains.Biological signature characteristics of primary isolates from human immunodeficiency virus type 1 group O in ex vivo human tonsil histocultures.Antitumor HPV E7-specific CTL activity elicited by in vivo engineered exosomes produced through DNA inoculation.The host-cell restriction factor SERINC5 restricts HIV-1 infectivity without altering the lipid composition and organization of viral particles.Vpx overcomes a SAMHD1-independent block to HIV reverse transcription that is specific to resting CD4 T cells.The Nef protein of human immunodeficiency virus is a broad-spectrum modulator of chemokine receptor cell surface levels that acts independently of classical motifs for receptor endocytosis and Galphai signaling.Human cyclin T1 expression ameliorates a T-cell-specific transcriptional limitation for HIV in transgenic rats, but is not sufficient for a spreading infection of prototypic R5 HIV-1 strains ex vivo.The HIV-1 pathogenicity factor Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity.
P2860
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P2860
Rodent cells support key functions of the human immunodeficiency virus type 1 pathogenicity factor Nef
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2005 nî lūn-bûn
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2005年の論文
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2005年学术文章
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2005年学术文章
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2005年学术文章
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2005年学术文章
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Rodent cells support key funct ...... ype 1 pathogenicity factor Nef
@en
type
label
Rodent cells support key funct ...... ype 1 pathogenicity factor Nef
@en
prefLabel
Rodent cells support key funct ...... ype 1 pathogenicity factor Nef
@en
P2093
P2860
P1433
P1476
Rodent cells support key funct ...... ype 1 pathogenicity factor Nef
@en
P2093
Ina Allespach
Lismarie Schüller
Oliver T Keppler
Warner C Greene
P2860
P304
P356
10.1128/JVI.79.3.1655-1665.2005
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P577
2005-02-01T00:00:00Z