Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.
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Structure of Natural Killer Receptor 2B4 Bound to CD48 Reveals Basis for Heterophilic Recognition in Signaling Lymphocyte Activation Molecule FamilyInfluence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell functionHomotypic interactions mediated by Slamf1 and Slamf6 receptors control NKT cell lineage developmentCutting edge: The adapters EAT-2A and -2B are positive regulators of CD244- and CD84-dependent NK cell functions in the C57BL/6 mouseRequirement of homotypic NK-cell interactions through 2B4(CD244)/CD48 in the generation of NK effector functionsUp on the tightrope: natural killer cell activation and inhibitionSLAM-family receptors: immune regulators with or without SAP-family adaptors.Absence of mouse 2B4 promotes NK cell-mediated killing of activated CD8+ T cells, leading to prolonged viral persistence and altered pathogenesis.Opportunities and limitations of natural killer cells as adoptive therapy for malignant diseaseOncogenic stress sensed by the immune system: role of natural killer cell receptorsRecognition of tumors by the innate immune system and natural killer cells.NK cells and their ability to modulate T cells during virus infectionsInvolvement of CD244 in regulating CD4+ T cell immunity in patients with active tuberculosis.Cutting edge: an NK cell-independent role for Slamf4 in controlling humoral autoimmunity.Differential expression of proteins in naïve and IL-2 stimulated primary human NK cells identified by global proteomic analysis.Murine lung cancer induces generalized T-cell exhaustion.Inhibition of Donor-Reactive CD8+ T Cell Responses by Selective CD28 Blockade Is Independent of Reduced ICOS Expression.2B4 Is Dispensable for T-Dependent B Cell Immune Responses, but Its Deficiency Leads to Enhanced T-Independent Responses Due to an Increase in Peritoneal Cavity B1b Cells.2B4 (CD244)-CD48 interactions provide a novel MHC class I-independent system for NK-cell self-tolerance in mice.2B4 inhibits NK-cell fratricide.A new self: MHC-class-I-independent natural-killer-cell self-tolerance.An ENU mutagenesis approach to dissect "self"-induced immune responses: Unraveling the genetic footprint of immunosurveillance.Immune regulation by SLAM family receptors and SAP-related adaptors.Evolving role of 2B4/CD244 in T and NK cell responses during virus infection.NK cell regulation by SLAM family receptors and SAP-related adapters.Roles of CD48 in regulating immunity and tolerance.Deletion of Slam locus in mice reveals inhibitory role of SLAM family in NK cell responses regulated by cytokines and LFA-1.2B4 (CD244) induced by selective CD28 blockade functionally regulates allograft-specific CD8+ T cell responses.X-linked lymphoproliferative syndrome: a genetic condition typified by the triad of infection, immunodeficiency and lymphoma.Immune evasion by oncogenic proteins of acute myeloid leukemia.T Cell Cosignaling Molecules in Transplantation.NKG2D ligation relieves 2B4-mediated NK-cell self-tolerance in mice.Functional role of human NK cell receptor 2B4 (CD244) isoforms.Fine-tuning of CD8(+) T-cell effector functions by targeting the 2B4-CD48 interaction.Homotypic cell to cell cross-talk among human natural killer cells reveals differential and overlapping roles of 2B4 and CD2.The Molecular Mechanism of Natural Killer Cells Function and Its Importance in Cancer Immunotherapy.Human natural killer cell receptor 2B4 (CD244) down-regulates its own expression by reduced promoter activity at an Ets element.Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythematosus.The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function.Immunomodulatory effects in the spleen-injured mice following exposure to titanium dioxide nanoparticles.
P2860
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P2860
Targeted disruption of the 2B4 gene in mice reveals an in vivo role of 2B4 (CD244) in the rejection of B16 melanoma cells.
description
2005 nî lūn-bûn
@nan
2005年の論文
@ja
2005年学术文章
@wuu
2005年学术文章
@zh-cn
2005年学术文章
@zh-hans
2005年学术文章
@zh-my
2005年学术文章
@zh-sg
2005年學術文章
@yue
2005年學術文章
@zh
2005年學術文章
@zh-hant
name
Targeted disruption of the 2B4 ...... jection of B16 melanoma cells.
@en
type
label
Targeted disruption of the 2B4 ...... jection of B16 melanoma cells.
@en
prefLabel
Targeted disruption of the 2B4 ...... jection of B16 melanoma cells.
@en
P2093
P1476
Targeted disruption of the 2B4 ...... jection of B16 melanoma cells.
@en
P2093
Colin L Stewart
Kyung-Mi Lee
Megan E McNerney
Michael Bennett
Porunelloor A Mathew
Susan E Stepp
Swapnil V Vaidya
Vinay Kumar
P304
P356
10.4049/JIMMUNOL.174.2.800
P407
P577
2005-01-01T00:00:00Z