CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.
about
Naked2 acts as a cargo recognition and targeting protein to ensure proper delivery and fusion of TGF-alpha containing exocytic vesicles at the lower lateral membrane of polarized MDCK cells.HIV-1 Nef disrupts intracellular trafficking of major histocompatibility complex class I, CD4, CD8, and CD28 by distinct pathways that share common elementsNef does not contribute to replication differences between R5 pre-AIDS and AIDS HIV-1 clones from patient ACH142SIV Nef proteins recruit the AP-2 complex to antagonize Tetherin and facilitate virion release.Human immunodeficiency virus Nef induces rapid internalization of the T-cell coreceptor CD8alphabetaHIV-1 Nef binds a subpopulation of MHC-I throughout its trafficking itinerary and down-regulates MHC-I by perturbing both anterograde and retrograde trafficking.Interaction of HIV-1 Nef protein with the host protein Alix promotes lysosomal targeting of CD4 receptor.Modulation of cellular protein trafficking by human immunodeficiency virus type 1 Nef: role of the acidic residue in the ExxxLL motif.Downregulation of CD4 by human immunodeficiency virus type 1 Nef is dependent on clathrin and involves direct interaction of Nef with the AP2 clathrin adaptor.A Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.AP-1 and ARF1 control endosomal dynamics at sites of FcR mediated phagocytosis.Enhancing siRNA effects in T cells for adoptive immunotherapy.A diacidic motif in human immunodeficiency virus type 1 Nef is a novel determinant of binding to AP-2Human immunodeficiency virus type 1 Nef: adapting to intracellular trafficking pathways.Reciprocal functional pseudotyping of HIV-1 and HTLV-1 viral genomes by the heterologous counterpart envelope proteins.Mechanisms of HIV-1 Nef function and intracellular signaling.HIV-1 Nef down-modulates C-C and C-X-C chemokine receptors via ubiquitin and ubiquitin-independent mechanismLipopeptides: a novel antigen repertoire presented by major histocompatibility complex class I molecules.Identification of molecular sub-networks associated with cell survival in a chronically SIVmac-infected human CD4+ T cell line.Packaging determinants in the UL11 tegument protein of herpes simplex virus type 1.Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.Nef-induced CD4 endocytosis in human immunodeficiency virus type 1 host cells: role of p56lck kinase.Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.
P2860
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P2860
CD4 down-regulation by HIV-1 and simian immunodeficiency virus (SIV) Nef proteins involves both internalization and intracellular retention mechanisms.
description
2004 nî lūn-bûn
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CD4 down-regulation by HIV-1 a ...... cellular retention mechanisms.
@en
type
label
CD4 down-regulation by HIV-1 a ...... cellular retention mechanisms.
@en
prefLabel
CD4 down-regulation by HIV-1 a ...... cellular retention mechanisms.
@en
P2093
P2860
P50
P356
P1476
CD4 down-regulation by HIV-1 a ...... cellular retention mechanisms.
@en
P2093
Jeremy J Rose
Soundararajulu Chandrasekhar
Sundararajan Venkatesan
P2860
P304
P356
10.1074/JBC.M409420200
P407
P577
2004-12-16T00:00:00Z