Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.
about
One protein to rule them all: modulation of cell surface receptors and molecules by HIV Nef.Interaction with the Src homology (SH3-SH2) region of the Src-family kinase Hck structures the HIV-1 Nef dimer for kinase activation and effector recruitmentHuman immunodeficiency virus type 1 Vpu and cellular TASK proteins suppress transcription of unintegrated HIV-1 DNA.Human immunodeficiency virus type 1 envelope gp120 induces a stop signal and virological synapse formation in noninfected CD4+ T cells.Patterns of HIV-1 protein interaction identify perturbed host-cellular subsystemsThe complexity of HIV persistence and pathogenesis in the lung under antiretroviral therapy: challenges beyond AIDS.Molecular Mechanisms of Neurodegenerative Diseases Induced by Human Retroviruses: A Review.Expression of Nef from unintegrated HIV-1 DNA downregulates cell surface CXCR4 and CCR5 on T-lymphocytes.SDF-1alpha is a potent inducer of HIV-1-Specific CD8+ T-cell chemotaxis, but migration of CD8+ T cells is impaired at high viral loads.Cell entry by human pathogenic arenaviruses.The role of unintegrated DNA in HIV infectionMisdirection of membrane trafficking by HIV-1 Vpu and Nef: Keys to viral virulence and persistence.HIV-susceptible transgenic rats allow rapid preclinical testing of antiviral compounds targeting virus entry or reverse transcriptionA Conserved GPG-Motif in the HIV-1 Nef Core Is Required for Principal Nef-Activities.Differential Ability of Primary HIV-1 Nef Isolates To Downregulate HIV-1 Entry Receptors.Primary T-cells from human CD4/CCR5-transgenic rats support all early steps of HIV-1 replication including integration, but display impaired viral gene expression.Old World arenavirus infection interferes with the expression of functional alpha-dystroglycan in the host cellDown-regulation of cell surface CXCR4 by HIV-1Aqueous extracts from peppermint, sage and lemon balm leaves display potent anti-HIV-1 activity by increasing the virion density.Dysregulation of autophagy by HIV-1 Nef in human astrocytes.Down-modulation of primate lentiviral receptors by Nef proteins of simian immunodeficiency virus (SIV) of chimpanzees (SIVcpz) and related SIVs: implication for the evolutionary event at the emergence of SIVcpz.Mouse T-cells restrict replication of human immunodeficiency virus at the level of integration.Nef can enhance the infectivity of receptor-pseudotyped human immunodeficiency virus type 1 particles.The Mamu B 17-restricted SIV Nef IW9 to TW9 mutation abrogates correct epitope processing and presentation without loss of replicative fitness.Human immunodeficiency virus type 1 Nef protein targets CD4 to the multivesicular body pathway.Mechanisms of enhanced HIV spread through T-cell virological synapses.Amino acids at positions 3, 168, and 169 are associated with the ability of Nef proteins from HIV-1 CRF01_AE to downmodulate CD4.HIV-1 Nef and Vpu are functionally redundant broad-spectrum modulators of cell surface receptors, including tetraspanins.SDF-1/CXCL12 production by mature dendritic cells inhibits the propagation of X4-tropic HIV-1 isolates at the dendritic cell-T-cell infectious synapse.Transcription of preintegrated HIV-1 cDNA modulates cell surface expression of major histocompatibility complex class I via Nef.Differential control of CXCR4 and CD4 downregulation by HIV-1 Gag.Inhibition of HIV-1 infection and replication by enhancing viral incorporation of innate anti-HIV-1 protein A3G: a non-pathogenic Nef mutant-based anti-HIV strategy.Human immunodeficiency virus type 1 Nef incorporation into virions does not increase infectivityDownmodulation of CCR7 by HIV-1 Vpu results in impaired migration and chemotactic signaling within CD4⁺ T cells.Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef functionSIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue
P2860
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P2860
Expression of Nef downregulates CXCR4, the major coreceptor of human immunodeficiency virus, from the surfaces of target cells and thereby enhances resistance to superinfection.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年学术文章
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2006年學術文章
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name
Expression of Nef downregulate ...... resistance to superinfection.
@en
Expression of Nef downregulate ...... resistance to superinfection.
@nl
type
label
Expression of Nef downregulate ...... resistance to superinfection.
@en
Expression of Nef downregulate ...... resistance to superinfection.
@nl
prefLabel
Expression of Nef downregulate ...... resistance to superinfection.
@en
Expression of Nef downregulate ...... resistance to superinfection.
@nl
P2093
P2860
P356
P1433
P1476
Expression of Nef downregulate ...... resistance to superinfection.
@en
P2093
Ina Allespach
Nico Michel
Oliver T Keppler
Stephanie Venzke
P2860
P304
11141-11152
P356
10.1128/JVI.01556-06
P407
P577
2006-08-23T00:00:00Z