DNA mismatch repair-dependent response to fluoropyrimidine-generated damage. - Wikidata - wikimedia - TriplyDB

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

http://www.wikidata.org/entity/Q40478691

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MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cells MicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)DNA mismatch repair: molecular mechanism, cancer, and ageing Tumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracil Human MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2.Genomic and epigenetic instability in colorectal cancer pathogenesis.Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitization Both hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stress Systemic treatment of advanced colorectal cancer: tailoring therapy to the tumor.Personalized colon cancer care in 2010.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Dynamics of uracil and 5-fluorouracil in DNA.UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.Structure and function of the components of the human DNA mismatch repair system.Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancer DNA mismatch repair and the DNA damage response.The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repair Chemotherapeutic implications in microsatellite unstable colorectal cancer.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.High-fidelity correction of genomic uracil by human mismatch repair activities.Participation of DNA repair in the response to 5-fluorouracil.DNA repair in murine embryonic stem cells and differentiated cells Uracil in DNA: consequences for carcinogenesis and chemotherapy Reduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.MicroRNAs as therapeutic targets in chemoresistance.Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases.DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.Radiotherapy response in microsatellite instability related rectal cancer Acidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.

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P2860

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

http://www.wikidata.org/entity/Q40478691

description

2004 nî lūn-bûn

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2004年の論文

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

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type

label

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

@en

prefLabel

DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

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Journal of Biological Chemistry

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DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.

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Anthony Mazurek

http://www.w3.org/2001/XMLSchema#string

Christoph Schmutte

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David A Boothman

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Mark Meyers

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Mark W Wagner

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Richard Fishel

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P2860

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

Functional interaction of proliferating cell nuclear antigen with MSH2-MSH6 and MSH2-MSH3 complexes

The interaction of DNA mismatch repair proteins with human exonuclease I

Activation of human MutS homologs by 8-oxo-guanine DNA damage

hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci

Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer

Requirement for PCNA in DNA mismatch repair at a step preceding DNA resynthesis.

Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase

Proliferating cell nuclear antigen and Msh2p-Msh6p interact to form an active mispair recognition complex

The thymine glycosylase MBD4 can bind to the product of deamination at methylated CpG sites

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5516-5526

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10.1074/JBC.M412105200

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7

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8119246

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15611052

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