DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
about
MSH3 mismatch repair protein regulates sensitivity to cytotoxic drugs and a histone deacetylase inhibitor in human colon carcinoma cellsMicroRNA-21 induces resistance to 5-fluorouracil by down-regulating human DNA MutS homolog 2 (hMSH2)DNA mismatch repair: molecular mechanism, cancer, and ageingTumor-specific microsatellite instability: do distinct mechanisms underlie the MSI-L and EMAST phenotypes?Base excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilHuman MLH1 suppresses the insertion of telomeric sequences at intra-chromosomal sites in telomerase-expressing cells.miR-1290 Is a Biomarker in DNA-Mismatch-Repair-Deficient Colon Cancer and Promotes Resistance to 5-Fluorouracil by Directly Targeting hMSH2.Genomic and epigenetic instability in colorectal cancer pathogenesis.Azidothymidine enhances fluorodeoxyuridine-mediated radiosensitizationBoth hMutSα and hMutSß DNA mismatch repair complexes participate in 5-fluorouracil cytotoxicity.Checkpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.SMUG1 but not UNG DNA glycosylase contributes to the cellular response to recovery from 5-fluorouracil induced replication stressSystemic treatment of advanced colorectal cancer: tailoring therapy to the tumor.Personalized colon cancer care in 2010.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Dynamics of uracil and 5-fluorouracil in DNA.UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation.WRN helicase promotes repair of DNA double-strand breaks caused by aberrant mismatch repair of chromium-DNA adducts.Structure and function of the components of the human DNA mismatch repair system.Mismatch repair defects and Lynch syndrome: The role of the basic scientist in the battle against cancerDNA mismatch repair and the DNA damage response.The Kub5-Hera/RPRD1B interactome: a novel role in preserving genetic stability by regulating DNA mismatch repairChemotherapeutic implications in microsatellite unstable colorectal cancer.5-Fluorouracil mediated anti-cancer activity in colon cancer cells is through the induction of Adenomatous Polyposis Coli: Implication of the long-patch base excision repair pathway.Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growthThe mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine.Microsatellite instability due to hMLH1 deficiency is associated with increased cytotoxicity to irinotecan in human colorectal cancer cell lines.High-fidelity correction of genomic uracil by human mismatch repair activities.Participation of DNA repair in the response to 5-fluorouracil.DNA repair in murine embryonic stem cells and differentiated cellsUracil in DNA: consequences for carcinogenesis and chemotherapyReduced ATR or Chk1 expression leads to chromosome instability and chemosensitization of mismatch repair-deficient colorectal cancer cells.Impairment of APE1 function enhances cellular sensitivity to clinically relevant alkylators and antimetabolites.MicroRNAs as therapeutic targets in chemoresistance.Comprehensive molecular analysis of mismatch repair gene defects in suspected Lynch syndrome (hereditary nonpolyposis colorectal cancer) cases.DNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.Pathological assessment of mismatch repair gene variants in Lynch syndrome: past, present, and future.Radiotherapy response in microsatellite instability related rectal cancerAcidic tumor microenvironment downregulates hMLH1 but does not diminish 5-fluorouracil chemosensitivity.Rapid DNA double-strand breaks resulting from processing of Cr-DNA cross-links by both MutS dimers.
P2860
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P2860
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
@en
type
label
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
@en
prefLabel
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
@en
P2093
P2860
P356
P1476
DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.
@en
P2093
Anthony Mazurek
Christoph Schmutte
David A Boothman
Mark Meyers
Mark W Wagner
Richard Fishel
P2860
P304
P356
10.1074/JBC.M412105200
P407
P577
2004-12-14T00:00:00Z