Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
about
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrityFas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosisThe thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genesModification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover5-halogenated pyrimidine lesions within a CpG sequence context mimic 5-methylcytosine by enhancing the binding of the methyl-CpG-binding domain of methyl-CpG-binding protein 2 (MeCP2).Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon CancerModifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseMismatch Repair in Methylated DNA: STRUCTURE AND ACTIVITY OF THE MISMATCH-SPECIFIC THYMINE GLYCOSYLASE DOMAIN OF METHYL-CpG-BINDING PROTEIN MBD4Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylationBiochemical and structural characterization of the glycosylase domain of MBD4 bound to thymine and 5-hydroxymethyuracil-containing DNAExcision of 5-hydroxymethyluracil and 5-carboxylcytosine by the thymine DNA glycosylase domain: its structural basis and implications for active DNA demethylationCrystal Structure of Human Methyl-Binding Domain IV Glycosylase Bound to Abasic DNABase excision by thymine DNA glycosylase mediates DNA-directed cytotoxicity of 5-fluorouracilInvestigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domainBase excision and DNA binding activities of human alkyladenine DNA glycosylase are sensitive to the base paired with a lesionRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesInvolvement of MBD4 inactivation in mismatch repair-deficient tumorigenesisMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesEpigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancerBCR-ABL1 kinase inhibits uracil DNA glycosylase UNG2 to enhance oxidative DNA damage and stimulate genomic instability.Methyl CpG binding proteins: coupling chromatin architecture to gene regulation.Single nucleotide polymorphism in the methyl-CpG binding domain 4 gene and the risk for immune thrombocytopenic purpura in Chinese population.Excision of 5-halogenated uracils by human thymine DNA glycosylase. Robust activity for DNA contexts other than CpG.Methyl-CpG binding proteins: specialized transcriptional repressors or structural components of chromatin?Human DNA mismatch repair in vitro operates independently of methylation status at CpG sitesCheckpoint signaling, base excision repair, and PARP promote survival of colon cancer cells treated with 5-fluorodeoxyuridine but not 5-fluorouracil.Nonspecific DNA binding and coordination of the first two steps of base excision repair.Role of MED1 (MBD4) Gene in DNA repair and human cancer.Base excision repair in a network of defence and tolerance.Mechanism of stimulation of the DNA glycosylase activity of hOGG1 by the major human AP endonuclease: bypass of the AP lyase activity stepRecent advances in the structural mechanisms of DNA glycosylasesMED1: a central molecule for maintenance of genome integrity and response to DNA damageIntegrative investigation on breast cancer in ER, PR and HER2-defined subgroups using mRNA and miRNA expression profiling.Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.MeCP2 and other methyl-CpG binding proteins.No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos.Effect of the thymidylate synthase inhibitors on dUTP and TTP pool levels and the activities of DNA repair glycosylases on uracil and 5-fluorouracil in DNA.Kinetic mechanism for the excision of hypoxanthine by Escherichia coli AlkA and evidence for binding to DNA ends.A role for DNA mismatch repair in sensing and responding to fluoropyrimidine damage.Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair.
P2860
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P2860
Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase
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2000 nî lūn-bûn
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2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
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2000 թվականի հոտեմբերին հրատարակված գիտական հոդված
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2000年の論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年論文
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2000年论文
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name
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@ast
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@en
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@nl
type
label
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@ast
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@en
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@nl
prefLabel
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@ast
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@en
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@nl
P2093
P2860
P3181
P356
P1476
Biphasic kinetics of the human ...... tch-specific DNA N-glycosylase
@en
P2093
A Bellacosa
F Petronzelli
G D Markham
J Stoerker
S H Seeholzer
P2860
P304
P3181
P356
10.1074/JBC.M004535200
P407
P577
2000-10-20T00:00:00Z