Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.
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A quantitative protein interaction network for the ErbB receptors using protein microarraysCancer systems biology: a network modeling perspectiveAnalysis of kinase gene expression patterns across 5681 human tissue samples reveals functional genomic taxonomy of the kinomeA comprehensive, multi-scale dynamical model of ErbB receptor signal transduction in human mammary epithelial cellsNonlinear pharmacokinetics of therapeutic proteins resulting from receptor mediated endocytosisRapid and sustained nuclear-cytoplasmic ERK oscillations induced by epidermal growth factor.Model-based analysis of HER activation in cells co-expressing EGFR, HER2 and HER3Cell surface receptors for signal transduction and ligand transport: a design principles study.System theoretical investigation of human epidermal growth factor receptor-mediated signalling.Input-output behavior of ErbB signaling pathways as revealed by a mass action model trained against dynamic dataCell-signalling dynamics in time and space.Modeling the effects of HER/ErbB1-3 coexpression on receptor dimerization and biological responseMultiple mechanisms are responsible for transactivation of the epidermal growth factor receptor in mammary epithelial cells.The role of the microenvironment in tumor growth and invasionEffects of HER2 overexpression on cell signaling networks governing proliferation and migration.Quantum dot-based quantitative immunofluorescence detection and spectrum analysis of epidermal growth factor receptor in breast cancer tissue arrays.Target points in trastuzumab resistancePredicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modellingRhamm-/- fibroblasts are defective in CD44-mediated ERK1,2 motogenic signaling, leading to defective skin wound repairLigand-dependent responses of the ErbB signaling network: experimental and modeling analyses.Development of a test that measures real-time HER2 signaling function in live breast cancer cell lines and primary cells.Integrated experimental and model-based analysis reveals the spatial aspects of EGFR activation dynamics.An electrostatic engine model for autoinhibition and activation of the epidermal growth factor receptor (EGFR/ErbB) familyA mathematical model for the rational design of chimeric ligands in selective drug therapies.System properties of ErbB receptor signaling for the understanding of cancer progression.Focal adhesion kinase-related proline-rich tyrosine kinase 2 and focal adhesion kinase are co-overexpressed in early-stage and invasive ErbB-2-positive breast cancer and cooperate for breast cancer cell tumorigenesis and invasiveness.Systems pharmacology and genome medicine: a future perspective.Personalizing therapies for gastric cancer: molecular mechanisms and novel targeted therapiesHER-2 signaling, acquisition of growth factor independence, and regulation of biological networks associated with cell transformation.Endocytosis and signalling: a meeting with mathematics.Circadian Gating of the Mammalian Cell Cycle Restriction Point: A Mathematical Analysis.A mathematical model for the effects of HER2 over-expression on cell cycle progression in breast cancer.Simulating non-small cell lung cancer with a multiscale agent-based model.An in silico canine cardiac midmyocardial action potential duration model as a tool for early drug safety assessment.Insulin-like growth factor type-I receptor internalization and recycling mediate the sustained phosphorylation of Akt.A hybrid model of tumor-stromal interactions in breast cancer.
P2860
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P2860
Parsing ERK activation reveals quantitatively equivalent contributions from epidermal growth factor receptor and HER2 in human mammary epithelial cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
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2004年学术文章
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2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
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name
Parsing ERK activation reveals ...... uman mammary epithelial cells.
@en
type
label
Parsing ERK activation reveals ...... uman mammary epithelial cells.
@en
prefLabel
Parsing ERK activation reveals ...... uman mammary epithelial cells.
@en
P2093
P2860
P356
P1476
Parsing ERK activation reveals ...... uman mammary epithelial cells.
@en
P2093
Bart S Hendriks
H Steven Wiley
P2860
P304
P356
10.1074/JBC.M410491200
P407
P577
2004-11-29T00:00:00Z