Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM. - Wikidata - wikimedia - TriplyDB

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

http://www.wikidata.org/entity/Q40491343

about

Phosphorylation of CLK2 at serine 34 and threonine 127 by AKT controls cell survival after ionizing radiation Regulation of TopBP1 oligomerization by Akt/PKB for cell survival Kinetic mechanism of AKT/PKB enzyme family A pharmacological map of the PI3-K family defines a role for p110alpha in insulin signaling SIRT6 in DNA repair, metabolism and ageing Cellular Pathways in Response to Ionizing Radiation and Their Targetability for Tumor Radiosensitization Pathogenesis of ataxia-telangiectasia: the next generation of ATM functions Reconstitution of the mammalian PI3K/PTEN/Akt pathway in yeast.Identification of p122RhoGAP (deleted in liver cancer-1) Serine 322 as a substrate for protein kinase B and ribosomal S6 kinase in insulin-stimulated cells Pseudo-DNA damage response in senescent cells Wip1 suppresses ovarian cancer metastasis through the ATM/AKT/Snail mediated signaling Pharmacologic profiling of phosphoinositide 3-kinase inhibitors as mitigators of ionizing radiation-induced cell death Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion PDK2: the missing piece in the receptor tyrosine kinase signaling pathway puzzle.ATM-dependent ERK signaling via AKT in response to DNA double-strand breaks.Role of ataxia telangiectasia mutated in insulin signalling of muscle-derived cell lines and mouse soleus.Mitochondria are required for pro-ageing features of the senescent phenotype.Lack of ataxia telangiectasia mutated kinase induces structural and functional changes in the heart: role in β-adrenergic receptor-stimulated apoptosis Receptor-specific mechanisms regulate phosphorylation of AKT at Ser473: role of RICTOR in β1 integrin-mediated cell survival.Role of AKT signaling in DNA repair and clinical response to cancer therapy.Akt: a double-edged sword in cell proliferation and genome stability.A role for AMPK in increased insulin action after serum starvation Neoadjuvant bevacizumab and chemoradiotherapy in locally advanced rectal cancer: early outcome and technical impact on toxicity.DNA damage signaling guards against perturbation of cyclin D1 expression triggered by low-dose long-term fractionated radiation ATM and GLUT1-S490 phosphorylation regulate GLUT1 mediated transport in skeletal muscle.Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines.High Id1 expression, a generally negative prognostic factor, paradoxically predicts a favorable prognosis for adjuvant paclitaxel plus cisplatin therapy in surgically treated lung cancer patients.Aberrant CD8+ T-cell responses and memory differentiation upon viral infection of an ataxia-telangiectasia mouse model driven by hyper-activated Akt and mTORC1 signaling.MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells.Tug of war between survival and death: exploring ATM function in cancer.ATM and ATR pathways signal alternative splicing of Drosophila TAF1 pre-mRNA in response to DNA damage.High mobility group A1 protein expression reduces the sensitivity of colon and thyroid cancer cells to antineoplastic drugs Hyperthermia Sensitizes Glioma Stem-like Cells to Radiation by Inhibiting AKT Signaling.Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression.Translational initiation regulated by ATM in dendritic cells development Improving DNA double-strand repair inhibitor KU55933 therapeutic index in cancer radiotherapy using nanoparticle drug delivery.IL-6 signaling contributes to cisplatin resistance in non-small cell lung cancer via the up-regulation of anti-apoptotic and DNA repair associated molecules Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice.Molecular imaging reveals a role for AKT in resistance to cisplatin for ovarian endometrioid adenocarcinoma Ataxia telangiectasia mutated impacts insulin-like growth factor 1 signalling in skeletal muscle.

P2860

Q24294362-0C139AFC-EA1F-4E72-A4BD-980F18BA5EAD Q24305051-B9C8DB59-3DBF-41F2-A138-64EE268E2E9A Q24307898-60AD8164-7D83-4CE1-81F2-C31BD8BD843A Q24599676-4518665B-555A-405C-92D4-C1D98766D1DE Q24653962-1F4868FC-AF0C-4BFA-89C1-E8E667C2BB3F Q26771165-8C7854B8-D6D7-47C4-9643-7DBAF6AB6C07 Q27025786-4AEF9597-9C96-4519-960E-FDD7F217B44F Q27933247-9B5525CD-64A4-42B3-95A5-CC6B7A41725F Q28285843-D5AA9A79-64FA-460D-9268-BC0808FC5DBC Q28583844-FE2F5378-D914-427B-940E-BC2FE76F7319 Q28828189-B86C7780-F1A5-47A2-B229-BF1D84AD3091 Q30409339-4C6AB0B1-4E59-4D20-9D67-C15E145BAD27 Q30434675-2206BB33-1EFF-41C4-B8C7-6DC9AE0249C1 Q33341346-41B6F0EF-FE16-4C1C-B453-1446FFDC9204 Q33802003-658D53A6-FB01-4C6D-B5A3-2DA8151B1F9E Q33871983-74397116-EEEC-4CB7-9A67-1488C5D4BFF5 Q34046100-7266641B-BD13-4E2B-AF75-96A806CCC92F Q34104704-3270417C-93ED-4814-9E62-6C12C301CB91 Q34182228-01197E90-B41C-426B-AA2D-633D2CCE5739 Q34193741-67BC9754-4CB2-4662-A779-BF2D8E274090 Q34223641-FA7BB3E8-5EEE-42A5-AFB3-91D9AE62B38A Q34304919-A336FA77-049C-4045-94E6-657CDD55EB15 Q34558472-8D72F0B5-6EA5-49D0-AD88-128CBA4391CC Q34766991-2D3F7BCA-9EEC-4A0B-91EB-3F0EDF0AA342 Q34776170-96076CB0-6276-4941-85D5-FBC3DEBC030D Q34806539-002B9BF8-5932-40DB-932C-30BB11DF8529 Q34956692-708D4DD0-48E1-43F5-BA0D-854530B528DE Q35071060-A7BC9A35-85EE-4EC3-93AE-FBBE23498833 Q35131665-54AAAD31-68F9-44FF-A889-4EECDF35A451 Q35134937-7E653D15-A231-4972-BB30-5F6D275595F4 Q35221375-A3B85B21-D421-43B0-839B-565C61EF5DCF Q35437204-FD95D618-0B1F-45B2-B2F1-5FF42D3AD8D5 Q35463653-BA09B0BA-9BE3-40A9-83BF-885737E4CC37 Q35636826-9D0C0B87-41ED-4054-A3C2-E810CA52F1B3 Q35966216-F8FF67DF-EBB7-4018-BCAA-FBEAB48D9B22 Q36331546-72EA2C3F-596A-4BF2-8885-64CB56A59EF2 Q36413863-5F9C8921-34C7-485B-A35D-171012E03753 Q36504423-B917CC69-A025-4BA8-901D-B78EE1A35C8C Q36511080-2BB227FC-DE52-49BD-933F-3137BFD3650B Q36557005-BFA8369B-44AA-430F-B93A-D4B68F63320B

P2860

Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM.

http://www.wikidata.org/entity/Q40491343

description

2004 nî lūn-bûn

@nan

2004年の論文

@ja

2004年学术文章

@wuu

2004年学术文章

@zh-cn

2004年学术文章

@zh-hans

2004年学术文章

@zh-my

2004年学术文章

@zh-sg

2004年學術文章

@yue

2004年學術文章

@zh

2004年學術文章

@zh-hant

name

Full activation of PKB/Akt in ...... ation is mediated through ATM.

@en

type

label

Full activation of PKB/Akt in ...... ation is mediated through ATM.

@en

prefLabel

Full activation of PKB/Akt in ...... ation is mediated through ATM.

@en

P1433

Q40491343-EBC0BC3B-F09E-4D6F-99D3-E067D1E16443

P1476

Q40491343-85B93307-67EE-4A36-AFD7-4A09BD208626

P2093

Q40491343-0D117563-216F-4EEB-8ECC-84D4A9583C71

Q40491343-160FA878-9CAA-4A90-B708-47BA18B3FEBB

Q40491343-297CCA64-8854-4DDF-852C-E74789B9C7D6

Q40491343-3DF92CC1-6C9C-41EB-AD77-14E1DA153230

Q40491343-44AB5799-9ED7-4DCC-86FE-B88793FF2609

Q40491343-6C0FA65C-245F-439A-860F-978120E81BAD

Q40491343-8CD2D462-05D4-4AE0-9EE6-AEAAB9E05E81

Q40491343-A1FD8C42-5E43-4D57-8ECE-E2E1B415F960

Q40491343-DBC7F9BA-B41B-4A36-94C6-038C851F191A

Q40491343-E2671D99-0CF2-4093-B450-68A1486E4237

P2860

Q40491343-06EF2162-D1BA-4EC1-A347-A0F7CC55413E

Q40491343-11453FF4-21CA-4C31-8D9C-E193A9CC19EE

Q40491343-1EC8BF6D-78BE-4B5C-9C88-413BE69475FC

Q40491343-226223BF-9E0D-4192-A6ED-C1FE593CCC40

Q40491343-2A8FED6A-81F2-4928-9562-B87BD3E976BE

Q40491343-3A9C139B-E49A-46EA-85D4-6B5D70AEB649

Q40491343-3D2BFED6-B3F8-40B3-95C5-74E3FEE0C187

Q40491343-529179D7-FC50-42CE-B4D3-B340C589D410

Q40491343-545D26E4-0CC5-4153-971B-337813C5D952

Q40491343-5A5DA008-E1F8-4D8B-9CCB-AA6FA09F9F61

P304

Q40491343-0A76307A-40A0-4E52-8107-100B57F9BAEF

P31

Q40491343-B31CA074-D6DF-465D-B78D-8F3B8CDAD074

P356

Q40491343-7D121D38-9CE6-4B26-A318-86CDF371336D

P407

Q40491343-9D6195BD-63D6-4F1B-A11F-C23C7C7FE39B

P433

Q40491343-151FA43F-67A3-46E6-9EB6-50992C733B51

P478

Q40491343-D8A2FCF3-1092-4CA3-9DB0-8FE888B044E7

P577

Q40491343-77CD801A-23B0-4215-AD90-283D24B9C6D4

P698

Q40491343-1C6EB334-7FA3-4981-907F-CB0890856770

P921

Q40491343-3025E4C4-0623-49CB-AF5F-F8B80C0AF537

P356

P1433

Journal of Biological Chemistry

P1476

Full activation of PKB/Akt in ...... ation is mediated through ATM.

@en

P2093

Carlos Parada Cobo

http://www.w3.org/2001/XMLSchema#string

Clara Isabel Aceves Luquero

http://www.w3.org/2001/XMLSchema#string

Javier Hernández Losa

http://www.w3.org/2001/XMLSchema#string

José María Rojas

http://www.w3.org/2001/XMLSchema#string

Juan Guinea Viniegra

http://www.w3.org/2001/XMLSchema#string

Luis Alvarez-Vallina

http://www.w3.org/2001/XMLSchema#string

Natalia Martínez

http://www.w3.org/2001/XMLSchema#string

Pegah Modirassari

http://www.w3.org/2001/XMLSchema#string

Ricardo Sánchez-Prieto

http://www.w3.org/2001/XMLSchema#string

Santiago Ramón y Cajal

http://www.w3.org/2001/XMLSchema#string

P2860

Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor

Activation of the ATM kinase by ionizing radiation and phosphorylation of p53

Activation of Akt/protein kinase B overcomes a G(2)/m cell cycle checkpoint induced by DNA damage

p38 Kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils

The many substrates and functions of ATM

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Characterization of PDK2 activity against protein kinase B gamma

Growth retardation and increased apoptosis in mice with homozygous disruption of the Akt1 gene

Enhanced phosphorylation of p53 by ATM in response to DNA damage

Domain swapping used to investigate the mechanism of protein kinase B regulation by 3-phosphoinositide-dependent protein kinase 1 and Ser473 kinase

P304

4029-4036

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1074/JBC.M410344200

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

280

http://www.w3.org/2001/XMLSchema#string

P577

2004-11-15T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P698

15546863

http://www.w3.org/2001/XMLSchema#string

P921